| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 3/31/2005 | SCO | Ohka | Traded away | FOR | | After |
| 4/1/2005 | KAN | Aquino | Demoted to reserve roster | | | Before |
| 4/1/2005 | KAN | Hernandez | Promoted to active roster | | | Before |
| 4/2/2005 | KAN | Floyd | Promoted to active roster | | | Before |
| 4/2/2005 | KAN | Lamb | Demoted to reserve roster | | | Before |
| 4/3/2005 | SCO | Lewis | Demoted to reserve roster | | | Before |
| 4/4/2005 | KAN | Lamb | Promoted to active roster | | | Before |
| 4/4/2005 | KAN | Miller | Promoted to active roster | | | Before |
| 4/4/2005 | KAN | Ortiz | Demoted to reserve roster | | | Before |
| 4/4/2005 | KAN | Sanchez | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Brocail | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Camp | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Dellucci | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Dellucci | Promoted to active roster | | | Before |
| 4/6/2005 | B C | DuBose | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Flaherty | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Gibbons | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Harvey | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Harvey | Promoted to active roster | | | Before |
| 4/6/2005 | B C | Mientkiewicz | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Osuna | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Ramirez | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Reyes | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Tadano | Demoted to reserve roster | | | Before |
| 4/7/2005 | PEA | Eyre | Promoted to active roster | | | Before |
| 4/7/2005 | PEA | Morneau | Demoted to reserve roster | | | Before |
| 4/7/2005 | SCO | Pickering | Promoted to active roster | | | Before |
| 4/7/2005 | SCO | Snyder | Demoted to reserve roster | | | Before |
| 4/9/2005 | KAN | Franco | Demoted to reserve roster | | | Before |
| 4/9/2005 | KAN | Ortiz | Promoted to active roster | | | Before |
| 4/14/2005 | KAN | Ginter | Promoted to active roster | | | Before |
| 4/14/2005 | KAN | Hernandez | Demoted to reserve roster | | | Before |
| 4/14/2005 | KAN | Lamb | Demoted to reserve roster | | | Before |
| 4/14/2005 | KAN | Miller | Demoted to reserve roster | | | Before |
| 4/14/2005 | KAN | Moyer | Promoted to active roster | | | Before |
| 4/14/2005 | KAN | Sanchez | Promoted to active roster | | | Before |
| 4/14/2005 | VIP | Buehrle | Demoted to reserve roster | | | Before |
| 4/14/2005 | VIP | Buehrle | Promoted to active roster | | | Before |
| 4/14/2005 | VIP | Hudson | Demoted to reserve roster | | | Before |
| 4/14/2005 | VIP | Penny | Promoted to active roster | | | Before |
| 4/19/2005 | KAN | Aquino | Promoted to active roster | | | Before |
| 4/19/2005 | KAN | Floyd | Demoted to reserve roster | | | Before |
| 4/19/2005 | KAN | Franco | Promoted to active roster | | | Before |
| 4/19/2005 | KAN | Lamb | Promoted to active roster | | | Before |
| 4/19/2005 | KAN | Piazza | Demoted to reserve roster | | | Before |
| 4/19/2005 | KAN | Redman | Demoted to reserve roster | | | Before |
| 4/19/2005 | KAN | Redman | Promoted to active roster | | | Before |
| 4/19/2005 | KAN | Remlinger | Demoted to reserve roster | | | Before |
| 4/19/2005 | KAN | Sanchez | Demoted to reserve roster | | | Before |
| 4/19/2005 | KAN | Sanchez | Promoted to active roster | | | Before |
| 4/20/2005 | B C | Brocail | Promoted to active roster | | | Before |
| 4/20/2005 | B C | DuBose | Promoted to active roster | | | Before |
| 4/20/2005 | B C | Harper | Demoted to reserve roster | | | Before |
| 4/20/2005 | B C | Lowe | Demoted to reserve roster | | | Before |
| 4/20/2005 | B C | Osuna | Promoted to active roster | | | Before |
| 4/20/2005 | B C | Riske | Demoted to reserve roster | | | Before |
| 4/20/2005 | DRI | Holliday | Demoted to reserve roster | | | Before |
| 4/20/2005 | DRI | Mackowiak | Promoted to active roster | | | Before |
| 4/20/2005 | PIN | Dempster | Promoted to active roster | | | Before |
| 4/20/2005 | PIN | Everett | Demoted to reserve roster | | | Before |
| 4/20/2005 | PIN | Nixon | Promoted to active roster | | | Before |
| 4/20/2005 | PIN | Qualls | Demoted to reserve roster | | | Before |
| 4/25/2005 | KAN | Lamb | Demoted to reserve roster | | | Before |
| 4/25/2005 | KAN | Piazza | Promoted to active roster | | | Before |
| 4/25/2005 | PIN | Dempster | Demoted to reserve roster | | | Before |
| 4/25/2005 | PIN | Everett | Promoted to active roster | | | Before |
| 4/25/2005 | PIN | Nixon | Demoted to reserve roster | | | Before |
| 4/25/2005 | PIN | Qualls | Promoted to active roster | | | Before |
| 4/27/2005 | B C | Lowe | Promoted to active roster | | | Before |
| 4/27/2005 | B C | Madritsch | Demoted to reserve roster | | | Before |
| 4/27/2005 | B C | Tadano | Promoted to active roster | | | Before |
| 4/27/2005 | B C | Washburn | Demoted to reserve roster | | | Before |
| 4/27/2005 | BAN | Bako | Signed | | | Before |
| 4/27/2005 | BAN | DeRosa | Signed | | | Before |
| 4/27/2005 | BAN | Quiroz | Demoted to reserve roster | | | Before |
| 4/27/2005 | BAN | Spiezio | Demoted to reserve roster | | | Before |
| 4/27/2005 | BAN | Spiezio | Promoted to active roster | | | Before |
| 4/27/2005 | IRI | Brazelton | Demoted to reserve roster | | | Before |
| 4/27/2005 | IRI | Gobble | Promoted to active roster | | | Before |
| 4/27/2005 | KAN | Bell | Demoted to reserve roster | | | Before |
| 4/27/2005 | KAN | Borkowski | Promoted to active roster | | | Before |
| 4/27/2005 | KAN | Floyd | Promoted to active roster | | | Before |
| 4/27/2005 | KAN | Ginter | Demoted to reserve roster | | | Before |
| 4/27/2005 | KAN | Hollandsworth | Demoted to reserve roster | | | Before |
| 4/27/2005 | KAN | Lamb | Promoted to active roster | | | Before |
| 4/27/2005 | KAN | Mesa | Demoted to reserve roster | | | Before |
| 4/27/2005 | KAN | Miller | Promoted to active roster | | | Before |
| 4/27/2005 | KAN | Munro | Promoted to active roster | | | Before |
| 4/27/2005 | KAN | Sanchez | Demoted to reserve roster | | | Before |
| 4/27/2005 | PEA | Carroll | Promoted to active roster | | | Before |
| 4/27/2005 | PEA | Klesko | Demoted to reserve roster | | | Before |
| 4/27/2005 | SKT | Gonzalez,L | Demoted to reserve roster | | | Before |
| 4/27/2005 | SKT | Ligtenberg | Promoted to active roster | | | Before |
| 4/27/2005 | SKT | Mendoza | Demoted to reserve roster | | | Before |
| 4/27/2005 | SKT | Obermueller | Promoted to active roster | | | Before |
| 4/27/2005 | SKT | Payton | Demoted to reserve roster | | | Before |
| 4/27/2005 | SKT | Santos | Demoted to reserve roster | | | Before |
| 4/27/2005 | SKT | Taguchi | Promoted to active roster | | | Before |
| 4/27/2005 | SKT | Tucker | Promoted to active roster | | | Before |
| 5/2/2005 | KAN | Aquino | Demoted to reserve roster | | | Before |
| 5/2/2005 | KAN | Borkowski | Demoted to reserve roster | | | Before |
| 5/2/2005 | KAN | Hernandez | Promoted to active roster | | | Before |
| 5/2/2005 | KAN | Hollandsworth | Promoted to active roster | | | Before |
| 5/2/2005 | KAN | Mercker | Demoted to reserve roster | | | Before |
| 5/2/2005 | KAN | Mercker | Promoted to active roster | | | Before |
| 5/2/2005 | KAN | Mercker | Demoted to reserve roster | | | Before |
| 5/2/2005 | KAN | Munro | Demoted to reserve roster | | | Before |
| 5/2/2005 | KAN | Offerman | Promoted to active roster | | | Before |
| 5/2/2005 | KAN | Remlinger | Promoted to active roster | | | Before |
| 5/3/2005 | B C | DaVanon | Demoted to reserve roster | | | Before |
| 5/3/2005 | B C | Gibbons | Promoted to active roster | | | Before |
| 5/3/2005 | BAN | Ensberg | Demoted to reserve roster | | | Before |
| 5/3/2005 | BAN | Ginter | Promoted to active roster | | | Before |
| 5/3/2005 | BAN | McLemore | Demoted to reserve roster | | | Before |
| 5/3/2005 | DRI | Castilla | Demoted to reserve roster | | | Before |
| 5/3/2005 | DRI | Castillo | Demoted to reserve roster | | | Before |
| 5/3/2005 | DRI | Castillo | Promoted to active roster | | | Before |
| 5/3/2005 | DRI | Clark | Demoted to reserve roster | | | Before |
| 5/3/2005 | DRI | Green | Demoted to reserve roster | | | Before |
| 5/3/2005 | DRI | Green | Promoted to active roster | | | Before |
| 5/3/2005 | DRI | Larson | Promoted to active roster | | | Before |
| 5/3/2005 | DRI | Raines | Promoted to active roster | | | Before |
| 5/3/2005 | DRI | Sele | Demoted to reserve roster | | | Before |
| 5/3/2005 | DRI | Sturtze | Promoted to active roster | | | Before |
| 5/3/2005 | DRI | Stynes | Demoted to reserve roster | | | Before |
| 5/3/2005 | DRI | Valent | Promoted to active roster | | | Before |
| 5/3/2005 | IRI | Adams,R | Demoted to reserve roster | | | Before |
| 5/3/2005 | IRI | Gonzalez | Promoted to active roster | | | Before |
| 5/3/2005 | PIN | Everett | Demoted to reserve roster | | | Before |
| 5/3/2005 | PIN | McEwing | Promoted to active roster | | | Before |
| 5/3/2005 | PIN | Nixon | Promoted to active roster | | | Before |
| 5/3/2005 | PIN | Young | Demoted to reserve roster | | | Before |
| 5/3/2005 | SKT | Gonzalez | Demoted to reserve roster | | | Before |
| 5/3/2005 | SKT | Lima | Demoted to reserve roster | | | Before |
| 5/3/2005 | SKT | Majewski | Promoted to active roster | | | Before |
| 5/3/2005 | SKT | Seo | Promoted to active roster | | | Before |
| 5/10/2005 | B C | Bush | Demoted to reserve roster | | | Before |
| 5/10/2005 | B C | Camp | Promoted to active roster | | | Before |
| 5/10/2005 | B C | DuBose | Demoted to reserve roster | | | Before |
| 5/10/2005 | B C | Flaherty | Demoted to reserve roster | | | Before |
| 5/10/2005 | B C | Flaherty | Promoted to active roster | | | Before |
| 5/10/2005 | B C | Harper | Promoted to active roster | | | Before |
| 5/10/2005 | B C | Lowe | Demoted to reserve roster | | | Before |
| 5/10/2005 | B C | Madritsch | Promoted to active roster | | | Before |
| 5/10/2005 | B C | Mientkiewicz | Demoted to reserve roster | | | Before |
| 5/10/2005 | B C | Mientkiewicz | Promoted to active roster | | | Before |
| 5/10/2005 | B C | Podsednik | Demoted to reserve roster | | | Before |
| 5/10/2005 | B C | Reyes | Promoted to active roster | | | Before |
| 5/10/2005 | B C | Tadano | Demoted to reserve roster | | | Before |
| 5/10/2005 | B C | Washburn | Promoted to active roster | | | Before |
| 5/10/2005 | DRI | Larson | Demoted to reserve roster | | | Before |
| 5/10/2005 | DRI | Palmeiro | Promoted to active roster | | | Before |
| 5/10/2005 | DRI | Stairs | Demoted to reserve roster | | | Before |
| 5/10/2005 | DRI | Stynes | Promoted to active roster | | | Before |
| 5/10/2005 | KAN | Lamb | Demoted to reserve roster | | | Before |
| 5/10/2005 | KAN | Mercker | Promoted to active roster | | | Before |
| 5/10/2005 | KAN | Remlinger | Demoted to reserve roster | | | Before |
| 5/10/2005 | KAN | Sanchez | Promoted to active roster | | | Before |
| 5/10/2005 | PEA | Carroll | Demoted to reserve roster | | | Before |
| 5/10/2005 | PEA | Klesko | Promoted to active roster | | | Before |
| 5/10/2005 | PIN | Jacobsen | Demoted to reserve roster | | | Before |
| 5/10/2005 | PIN | Logan | Promoted to active roster | | | Before |
| 5/10/2005 | SKT | Gonzalez | Demoted to reserve roster | | | Before |
| 5/10/2005 | SKT | Gonzalez,L | Demoted to reserve roster | | | Before |
| 5/10/2005 | SKT | Gonzalez,L | Promoted to active roster | | | Before |
| 5/10/2005 | SKT | Kata | Demoted to reserve roster | | | Before |
| 5/10/2005 | SKT | Kata | Promoted to active roster | | | Before |
| 5/10/2005 | SKT | Kata | Promoted to active roster | | | Before |
| 5/10/2005 | SKT | Olerud | Demoted to reserve roster | | | Before |
| 5/10/2005 | SKT | Payton | Promoted to active roster | | | Before |
| 5/10/2005 | SKT | Radke | Demoted to reserve roster | | | Before |
| 5/10/2005 | SKT | Santos | Promoted to active roster | | | Before |
| 5/10/2005 | SKT | Taguchi | Demoted to reserve roster | | | Before |
| 5/10/2005 | SKT | Zeile | Promoted to active roster | | | Before |
| 5/15/2005 | KAN | Bell | Promoted to active roster | | | Before |
| 5/15/2005 | KAN | Lamb | Promoted to active roster | | | Before |
| 5/15/2005 | KAN | Miller | Demoted to reserve roster | | | Before |
| 5/15/2005 | KAN | Sanchez | Demoted to reserve roster | | | Before |
| 5/15/2005 | PIN | Catalanotto | Promoted to active roster | | | Before |
| 5/15/2005 | PIN | Everett | Promoted to active roster | | | Before |
| 5/15/2005 | PIN | Hafner | Demoted to reserve roster | | | Before |
| 5/15/2005 | PIN | Jacobsen | Promoted to active roster | | | Before |
| 5/15/2005 | PIN | Logan | Demoted to reserve roster | | | Before |
| 5/15/2005 | PIN | Looper | Promoted to active roster | | | Before |
| 5/15/2005 | PIN | Nixon | Demoted to reserve roster | | | Before |
| 5/15/2005 | PIN | Percival | Demoted to reserve roster | | | Before |
| 5/15/2005 | PIN | Youkilis | Demoted to reserve roster | | | Before |
| 5/15/2005 | PIN | Young | Promoted to active roster | | | Before |
| 5/16/2005 | B C | Bush | Promoted to active roster | | | Before |
| 5/16/2005 | B C | Camp | Demoted to reserve roster | | | Before |
| 5/16/2005 | B C | Flaherty | Promoted to active roster | | | Before |
| 5/16/2005 | B C | Harvey | Demoted to reserve roster | | | Before |
| 5/16/2005 | B C | Lowe | Promoted to active roster | | | Before |
| 5/16/2005 | B C | Madritsch | Demoted to reserve roster | | | Before |
| 5/16/2005 | B C | Riske | Promoted to active roster | | | Before |
| 5/16/2005 | B C | Washburn | Demoted to reserve roster | | | Before |
| 5/16/2005 | PEA | Halladay | Demoted to reserve roster | | | Before |
| 5/16/2005 | PEA | Lieber | Promoted to active roster | | | Before |
| 5/16/2005 | PHO | Cantu | Demoted to reserve roster | | | Before |
| 5/16/2005 | PHO | Upton | Promoted to active roster | | | Before |
| 5/16/2005 | SCO | Chen | Promoted to active roster | | | Before |
| 5/16/2005 | SCO | Lopez,R | Demoted to reserve roster | | | Before |
| 5/16/2005 | SKT | Gonzalez,L | Promoted to active roster | | | Before |
| 5/16/2005 | SKT | Higginson | Demoted to reserve roster | | | Before |
| 5/16/2005 | SKT | Lima | Promoted to active roster | | | Before |
| 5/16/2005 | SKT | Majewski | Demoted to reserve roster | | | Before |
| 5/16/2005 | SKT | Mendoza | Promoted to active roster | | | Before |
| 5/16/2005 | SKT | Radke | Promoted to active roster | | | Before |
| 5/16/2005 | SKT | Seo | Demoted to reserve roster | | | Before |
| 5/16/2005 | SKT | Sierra | Demoted to reserve roster | | | Before |
| 5/16/2005 | SKT | Sierra | Promoted to active roster | | | Before |
| 5/16/2005 | SKT | Trachsel | Demoted to reserve roster | | | Before |
| 5/23/2005 | B C | Bush | Demoted to reserve roster | | | Before |
| 5/23/2005 | B C | DuBose | Promoted to active roster | | | Before |
| 5/23/2005 | B C | Lowe | Demoted to reserve roster | | | Before |
| 5/23/2005 | B C | Madritsch | Promoted to active roster | | | Before |
| 5/23/2005 | B C | Ramirez | Promoted to active roster | | | Before |
| 5/23/2005 | B C | Washburn | Promoted to active roster | | | Before |
| 5/23/2005 | BAN | Blum | Promoted to active roster | | | Before |
| 5/23/2005 | BAN | Ensberg | Promoted to active roster | | | Before |
| 5/23/2005 | BAN | Gil | Demoted to reserve roster | | | Before |
| 5/23/2005 | BAN | McLemore | Promoted to active roster | | | Before |
| 5/23/2005 | BAN | Nageotte | Demoted to reserve roster | | | Before |
| 5/23/2005 | BAN | Van Benschoten | Demoted to reserve roster | | | Before |
| 5/23/2005 | DRI | Castillo | Promoted to active roster | | | Before |
| 5/23/2005 | DRI | Fassero | Promoted to active roster | | | Before |
| 5/23/2005 | DRI | Levine | Demoted to reserve roster | | | Before |
| 5/23/2005 | DRI | Stairs | Promoted to active roster | | | Before |
| 5/23/2005 | DRI | Sturtze | Demoted to reserve roster | | | Before |
| 5/23/2005 | DRI | Stynes | Demoted to reserve roster | | | Before |
| 5/23/2005 | IRI | Choate | Promoted to active roster | | | Before |
| 5/23/2005 | IRI | Gobble | Demoted to reserve roster | | | Before |
| 5/23/2005 | IRI | Kazmir | Promoted to active roster | | | Before |
| 5/23/2005 | IRI | Seay | Demoted to reserve roster | | | Before |
| 5/23/2005 | IRI | Valverde | Promoted to active roster | | | Before |
| 5/23/2005 | IRI | Wuertz | Demoted to reserve roster | | | Before |
| 5/23/2005 | KAN | Aquino | Promoted to active roster | | | Before |
| 5/23/2005 | KAN | Betancourt | Demoted to reserve roster | | | Before |
| 5/23/2005 | KAN | Floyd | Demoted to reserve roster | | | Before |
| 5/23/2005 | KAN | Floyd | Promoted to active roster | | | Before |
| 5/23/2005 | KAN | Munro | Promoted to active roster | | | Before |
| 5/23/2005 | KAN | Surhoff | Demoted to reserve roster | | | Before |
| 5/23/2005 | PEA | Benson | Demoted to reserve roster | | | Before |
| 5/23/2005 | PEA | Burnett | Promoted to active roster | | | Before |
| 5/23/2005 | PEA | Carroll | Promoted to active roster | | | Before |
| 5/23/2005 | PEA | Erstad | Demoted to reserve roster | | | Before |
| 5/23/2005 | PEA | Freeman | Promoted to active roster | | | Before |
| 5/23/2005 | PEA | Klesko | Demoted to reserve roster | | | Before |
| 5/23/2005 | PEA | Morneau | Promoted to active roster | | | Before |
| 5/23/2005 | PEA | Uribe | Demoted to reserve roster | | | Before |
| 5/23/2005 | PIN | Everett | Demoted to reserve roster | | | Before |
| 5/23/2005 | PIN | Hafner | Promoted to active roster | | | Before |
| 5/23/2005 | PIN | Percival | Promoted to active roster | | | Before |
| 5/23/2005 | PIN | Qualls | Demoted to reserve roster | | | Before |
| 5/23/2005 | PIN | Youkilis | Promoted to active roster | | | Before |
| 5/23/2005 | PIN | Young | Demoted to reserve roster | | | Before |
| 5/23/2005 | SKT | Gonzalez | Promoted to active roster | | | Before |
| 5/23/2005 | SKT | Gonzalez | Promoted to active roster | | | Before |
| 5/23/2005 | SKT | Lima | Demoted to reserve roster | | | Before |
| 5/23/2005 | SKT | Mendoza | Demoted to reserve roster | | | Before |
| 5/23/2005 | SKT | Sierra | Demoted to reserve roster | | | Before |
| 5/23/2005 | SKT | Trachsel | Promoted to active roster | | | Before |
| 5/28/2005 | B C | DaVanon | Promoted to active roster | | | Before |
| 5/28/2005 | B C | DuBose | Demoted to reserve roster | | | Before |
| 5/28/2005 | B C | Gibbons | Demoted to reserve roster | | | Before |
| 5/28/2005 | B C | Osuna | Demoted to reserve roster | | | Before |
| 5/28/2005 | PHO | Wright | Traded away | FOR | | After |
| 5/28/2005 | PIN | Everett | Promoted to active roster | | | Before |
| 5/28/2005 | PIN | Hatteberg | Demoted to reserve roster | | | Before |
| 5/28/2005 | PIN | Logan | Demoted to reserve roster | | | Before |
| 5/28/2005 | PIN | Logan | Promoted to active roster | | | Before |
| 5/28/2005 | PIN | Youkilis | Demoted to reserve roster | | | Before |
| 5/28/2005 | PIN | Young | Promoted to active roster | | | Before |
| 5/28/2005 | SCO | Hawkins | Traded away | HEN | | After |
| 5/28/2005 | SCO | Hawkins | Traded away | HEN | | After |
| 5/28/2005 | SCO | Hawkins | Acquired via trade | HEN | | After |
| 5/29/2005 | B C | Camp | Promoted to active roster | | | Before |
| 5/29/2005 | B C | DaVanon | Demoted to reserve roster | | | Before |
| 5/29/2005 | B C | Harper | Demoted to reserve roster | | | Before |
| 5/29/2005 | B C | Harvey | Promoted to active roster | | | Before |
| 5/29/2005 | B C | Madritsch | Demoted to reserve roster | | | Before |
| 5/29/2005 | B C | Martinez | Demoted to reserve roster | | | Before |
| 5/29/2005 | B C | Mientkiewicz | Promoted to active roster | | | Before |
| 5/29/2005 | B C | Podsednik | Promoted to active roster | | | Before |
| 5/29/2005 | B C | Ramirez | Demoted to reserve roster | | | Before |
| 5/29/2005 | B C | Tadano | Promoted to active roster | | | Before |
| 5/29/2005 | BAN | Guiel | Demoted to reserve roster | | | Before |
| 5/29/2005 | BAN | Guzman | Promoted to active roster | | | Before |
| 5/29/2005 | BAN | Krynzel | Demoted to reserve roster | | | Before |
| 5/29/2005 | IRI | Glaus | Demoted to reserve roster | | | Before |
| 5/29/2005 | IRI | Wellemeyer | Promoted to active roster | | | Before |
| 5/29/2005 | KAN | Anderson | Promoted to active roster | | | Before |
| 5/29/2005 | KAN | Ortiz | Demoted to reserve roster | | | Before |
| 5/29/2005 | PEA | Benson | Promoted to active roster | | | Before |
| 5/29/2005 | PEA | Burnett | Demoted to reserve roster | | | Before |
| 5/29/2005 | PEA | Erstad | Demoted to reserve roster | | | Before |
| 5/29/2005 | PEA | Erstad | Promoted to active roster | | | Before |
| 5/29/2005 | PEA | Klesko | Promoted to active roster | | | Before |
| 5/29/2005 | PEA | Thomas | Demoted to reserve roster | | | Before |
| 5/29/2005 | PHO | Sparks | Signed | | | Before |
| 5/29/2005 | SCO | Lincoln | Signed | | | Before |
| 5/29/2005 | SCO | Waechter | Promoted to active roster | | | Before |
| 5/29/2005 | SCO | Wells | Demoted to reserve roster | | | Before |
| 5/29/2005 | SKT | Biddle | Promoted to active roster | | | Before |
| 5/29/2005 | SKT | Hillenbrand | Demoted to reserve roster | | | Before |
| 5/29/2005 | SKT | Lima | Promoted to active roster | | | Before |
| 5/29/2005 | SKT | Obermueller | Demoted to reserve roster | | | Before |
| 5/29/2005 | SKT | Sierra | Promoted to active roster | | | Before |
| 5/29/2005 | SKT | Walker | Demoted to reserve roster | | | Before |
| 5/29/2005 | VIP | Majewski | Released | | | Before |
| 5/29/2005 | VIP | Sanchez | Signed | | | Before |
| 5/29/2005 | VIP | Utley | Demoted to reserve roster | | | Before |
| 6/5/2005 | BAN | Chavez | Signed | | | Before |
| 6/5/2005 | BAN | Gil | Released | | | Before |
| 6/5/2005 | BAN | Gil | Released | | | Before |
| 6/5/2005 | BAN | Gil | Signed | | | Before |
| 6/5/2005 | DRI | Koch | Demoted to reserve roster | | | Before |
| 6/5/2005 | DRI | Larson | Promoted to active roster | | | Before |
| 6/5/2005 | DRI | Matthews | Promoted to active roster | | | Before |
| 6/5/2005 | DRI | Palmeiro | Demoted to reserve roster | | | Before |
| 6/5/2005 | PEA | Bell | Demoted to reserve roster | | | Before |
| 6/5/2005 | PEA | Burnett | Promoted to active roster | | | Before |
| 6/5/2005 | PEA | Erstad | Promoted to active roster | | | Before |
| 6/5/2005 | PEA | Freeman | Demoted to reserve roster | | | Before |
| 6/5/2005 | PEA | Klesko | Demoted to reserve roster | | | Before |
| 6/5/2005 | PEA | Pineiro | Demoted to reserve roster | | | Before |
| 6/5/2005 | PEA | Thomas | Demoted to reserve roster | | | Before |
| 6/5/2005 | PEA | Thomas | Promoted to active roster | | | Before |
| 6/5/2005 | PEA | Thomas | Promoted to active roster | | | Before |
| 6/5/2005 | PEA | Uribe | Promoted to active roster | | | Before |
| 6/5/2005 | PHO | Cruz | Demoted to reserve roster | | | Before |
| 6/5/2005 | PHO | Gaudin | Promoted to active roster | | | Before |
| 6/5/2005 | PIN | Cash | Promoted to active roster | | | Before |
| 6/5/2005 | PIN | Catalanotto | Demoted to reserve roster | | | Before |
| 6/5/2005 | PIN | Dempster | Promoted to active roster | | | Before |
| 6/5/2005 | PIN | Everett | Demoted to reserve roster | | | Before |
| 6/5/2005 | PIN | Hatteberg | Promoted to active roster | | | Before |
| 6/5/2005 | PIN | Jacobsen | Demoted to reserve roster | | | Before |
| 6/5/2005 | PIN | Logan | Promoted to active roster | | | Before |
| 6/5/2005 | PIN | Miller | Demoted to reserve roster | | | Before |
| 6/5/2005 | PIN | Nixon | Promoted to active roster | | | Before |
| 6/5/2005 | PIN | Torrealba | Demoted to reserve roster | | | Before |
| 6/5/2005 | SCO | Cameron | Demoted to reserve roster | | | Before |
| 6/5/2005 | SCO | Chen | Demoted to reserve roster | | | Before |
| 6/5/2005 | SCO | Mateo | Promoted to active roster | | | Before |
| 6/5/2005 | SCO | Pickering | Demoted to reserve roster | | | Before |
| 6/5/2005 | SCO | Sizemore | Promoted to active roster | | | Before |
| 6/5/2005 | SCO | Snyder | Promoted to active roster | | | Before |
| 6/5/2005 | SKT | Kata | Demoted to reserve roster | | | Before |
| 6/5/2005 | SKT | Lima | Demoted to reserve roster | | | Before |
| 6/5/2005 | SKT | Mendoza | Promoted to active roster | | | Before |
| 6/5/2005 | SKT | Seo | Promoted to active roster | | | Before |
| 6/10/2005 | B C | Brocail | Demoted to reserve roster | | | Before |
| 6/10/2005 | B C | Bush | Promoted to active roster | | | Before |
| 6/10/2005 | B C | Camp | Demoted to reserve roster | | | Before |
| 6/10/2005 | B C | DaVanon | Promoted to active roster | | | Before |
| 6/10/2005 | B C | Dellucci | Demoted to reserve roster | | | Before |
| 6/10/2005 | B C | Harper | Promoted to active roster | | | Before |
| 6/10/2005 | B C | Lowe | Promoted to active roster | | | Before |
| 6/10/2005 | B C | Madritsch | Promoted to active roster | | | Before |
| 6/10/2005 | B C | Reyes | Demoted to reserve roster | | | Before |
| 6/10/2005 | B C | Washburn | Demoted to reserve roster | | | Before |
| 6/10/2005 | PIN | Cash | Demoted to reserve roster | | | Before |
| 6/10/2005 | PIN | Torrealba | Promoted to active roster | | | Before |
| 6/11/2005 | B C | Bush | Demoted to reserve roster | | | Before |
| 6/11/2005 | B C | Lowe | Demoted to reserve roster | | | Before |
| 6/11/2005 | B C | Reyes | Promoted to active roster | | | Before |
| 6/11/2005 | B C | Washburn | Promoted to active roster | | | Before |
| 6/11/2005 | KAN | Betancourt | Promoted to active roster | | | Before |
| 6/11/2005 | KAN | Ginter | Promoted to active roster | | | Before |
| 6/11/2005 | KAN | Hollandsworth | Demoted to reserve roster | | | Before |
| 6/11/2005 | KAN | Lamb | Demoted to reserve roster | | | Before |
| 6/11/2005 | KAN | Mesa | Promoted to active roster | | | Before |
| 6/11/2005 | KAN | Miller | Promoted to active roster | | | Before |
| 6/11/2005 | KAN | Munro | Demoted to reserve roster | | | Before |
| 6/11/2005 | KAN | Offerman | Demoted to reserve roster | | | Before |
| 6/11/2005 | KAN | Redman | Promoted to active roster | | | Before |
| 6/11/2005 | KAN | Sanchez | Promoted to active roster | | | Before |
| 6/11/2005 | KAN | Surhoff | Promoted to active roster | | | Before |
| 6/11/2005 | KAN | Thomas | Demoted to reserve roster | | | Before |
| 6/11/2005 | PEA | Cintron | Demoted to reserve roster | | | Before |
| 6/11/2005 | PEA | Klesko | Promoted to active roster | | | Before |
| 6/11/2005 | PHO | Cantu | Demoted to reserve roster | | | Before |
| 6/11/2005 | PHO | Cantu | Promoted to active roster | | | Before |
| 6/11/2005 | PHO | Upton | Demoted to reserve roster | | | Before |
| 6/11/2005 | PHO | Upton | Promoted to active roster | | | Before |
| 6/11/2005 | PIN | Everett | Promoted to active roster | | | Before |
| 6/11/2005 | PIN | Nixon | Demoted to reserve roster | | | Before |
| 6/11/2005 | PIN | Youkilis | Promoted to active roster | | | Before |
| 6/11/2005 | PIN | Young | Demoted to reserve roster | | | Before |
| 6/11/2005 | SCO | Lopez,R | Promoted to active roster | | | Before |
| 6/11/2005 | SCO | Waechter | Demoted to reserve roster | | | Before |
| 6/11/2005 | SKT | Hillenbrand | Promoted to active roster | | | Before |
| 6/11/2005 | SKT | Ligtenberg | Demoted to reserve roster | | | Before |
| 6/11/2005 | SKT | Mendoza | Demoted to reserve roster | | | Before |
| 6/11/2005 | SKT | Obermueller | Promoted to active roster | | | Before |
| 6/11/2005 | SKT | Trachsel | Demoted to reserve roster | | | Before |
| 6/11/2005 | SKT | Zeile | Demoted to reserve roster | | | Before |
| 6/16/2005 | IRI | Atchison | Promoted to active roster | | | Before |
| 6/16/2005 | IRI | Balfour | Demoted to reserve roster | | | Before |
| 6/18/2005 | BAN | Brazell | Demoted to reserve roster | | | Before |
| 6/18/2005 | BAN | Everett | Demoted to reserve roster | | | Before |
| 6/18/2005 | BAN | Everett | Promoted to active roster | | | Before |
| 6/18/2005 | BAN | Guzman | Demoted to reserve roster | | | Before |
| 6/18/2005 | BAN | Van Benschoten | Promoted to active roster | | | Before |
| 6/18/2005 | BAN | Williams | Demoted to reserve roster | | | Before |
| 6/18/2005 | IRI | Gobble | Promoted to active roster | | | Before |
| 6/18/2005 | IRI | Kazmir | Demoted to reserve roster | | | Before |
| 6/18/2005 | PEA | Bell | Promoted to active roster | | | Before |
| 6/18/2005 | PEA | Cintron | Demoted to reserve roster | | | Before |
| 6/18/2005 | PEA | Cintron | Promoted to active roster | | | Before |
| 6/18/2005 | PEA | Morneau | Demoted to reserve roster | | | Before |
| 6/18/2005 | PIN | Catalanotto | Demoted to reserve roster | | | Before |
| 6/18/2005 | PIN | Catalanotto | Promoted to active roster | | | Before |
| 6/18/2005 | PIN | Catalanotto | Promoted to active roster | | | Before |
| 6/18/2005 | PIN | Logan | Demoted to reserve roster | | | Before |
| 6/18/2005 | PIN | Logan | Promoted to active roster | | | Before |
| 6/18/2005 | PIN | McEwing | Demoted to reserve roster | | | Before |
| 6/18/2005 | PIN | Youkilis | Demoted to reserve roster | | | Before |
| 6/18/2005 | PIN | Young | Promoted to active roster | | | Before |
| 6/18/2005 | SCO | Cameron | Promoted to active roster | | | Before |
| 6/18/2005 | SCO | Gonzalez,E | Promoted to active roster | | | Before |
| 6/18/2005 | SCO | Pickering | Promoted to active roster | | | Before |
| 6/18/2005 | SCO | Sizemore | Demoted to reserve roster | | | Before |
| 6/18/2005 | SCO | Snyder | Demoted to reserve roster | | | Before |
| 6/18/2005 | SCO | Wise | Demoted to reserve roster | | | Before |
| 6/18/2005 | SKT | Adams | Demoted to reserve roster | | | Before |
| 6/18/2005 | SKT | Gonzalez | Demoted to reserve roster | | | Before |
| 6/18/2005 | SKT | Higginson | Promoted to active roster | | | Before |
| 6/18/2005 | SKT | Ishii | Demoted to reserve roster | | | Before |
| 6/18/2005 | SKT | Lima | Promoted to active roster | | | Before |
| 6/18/2005 | SKT | Majewski | Promoted to active roster | | | Before |
| 6/18/2005 | SKT | Walker | Promoted to active roster | | | Before |
| 6/18/2005 | SKT | Zeile | Promoted to active roster | | | Before |
| 6/23/2005 | PIN | Dempster | Demoted to reserve roster | | | Before |
| 6/23/2005 | PIN | McEwing | Promoted to active roster | | | Before |
| 6/23/2005 | PIN | Qualls | Promoted to active roster | | | Before |
| 6/23/2005 | PIN | Reese | Demoted to reserve roster | | | Before |
| 6/23/2005 | PIN | Youkilis | Promoted to active roster | | | Before |
| 6/23/2005 | PIN | Young | Demoted to reserve roster | | | Before |
| 6/24/2005 | B C | Bush | Promoted to active roster | | | Before |
| 6/24/2005 | B C | Cordero | Demoted to reserve roster | | | Before |
| 6/24/2005 | B C | Flaherty | Demoted to reserve roster | | | Before |
| 6/24/2005 | B C | Gibbons | Promoted to active roster | | | Before |
| 6/24/2005 | B C | Lowe | Promoted to active roster | | | Before |
| 6/24/2005 | B C | Washburn | Demoted to reserve roster | | | Before |
| 6/24/2005 | IRI | Brazelton | Promoted to active roster | | | Before |
| 6/24/2005 | IRI | May | Demoted to reserve roster | | | Before |
| 6/24/2005 | PEA | Carroll | Demoted to reserve roster | | | Before |
| 6/24/2005 | PEA | Cintron | Promoted to active roster | | | Before |
| 6/24/2005 | PHO | Feliz | Demoted to reserve roster | | | Before |
| 6/24/2005 | PHO | Kolb | Demoted to reserve roster | | | Before |
| 6/24/2005 | PHO | Reed | Promoted to active roster | | | Before |
| 6/24/2005 | PHO | Valentine | Promoted to active roster | | | Before |
| 6/24/2005 | SCO | Flores | Signed | | | Before |
| 6/24/2005 | SCO | Flores | Demoted to reserve roster | | | Before |
| 6/24/2005 | SCO | Gonzalez,E | Demoted to reserve roster | | | Before |
| 6/24/2005 | SCO | Lewis | Promoted to active roster | | | Before |
| 6/24/2005 | SCO | Lincoln | Released | | | Before |
| 6/24/2005 | SCO | Moreno | Promoted to active roster | | | Before |
| 6/24/2005 | SKT | Biddle | Demoted to reserve roster | | | Before |
| 6/24/2005 | SKT | Gonzalez | Promoted to active roster | | | Before |
| 6/24/2005 | SKT | Higginson | Demoted to reserve roster | | | Before |
| 6/24/2005 | SKT | Ishii | Promoted to active roster | | | Before |
| 6/24/2005 | SKT | Majewski | Demoted to reserve roster | | | Before |
| 6/24/2005 | SKT | Mendoza | Promoted to active roster | | | Before |
| 6/24/2005 | SKT | Seo | Demoted to reserve roster | | | Before |
| 6/24/2005 | SKT | Taguchi | Promoted to active roster | | | Before |
| 7/1/2005 | B C | Bush | Demoted to reserve roster | | | Before |
| 7/1/2005 | B C | Cordero | Promoted to active roster | | | Before |
| 7/1/2005 | B C | Harvey | Demoted to reserve roster | | | Before |
| 7/1/2005 | B C | Martinez | Promoted to active roster | | | Before |
| 7/1/2005 | B C | Mientkiewicz | Demoted to reserve roster | | | Before |
| 7/1/2005 | B C | Washburn | Promoted to active roster | | | Before |
| 7/1/2005 | DRI | Bloomquist | Demoted to reserve roster | | | Before |
| 7/1/2005 | DRI | Castilla | Promoted to active roster | | | Before |
| 7/1/2005 | DRI | Castillo | Demoted to reserve roster | | | Before |
| 7/1/2005 | DRI | Clark | Promoted to active roster | | | Before |
| 7/1/2005 | DRI | Holliday | Promoted to active roster | | | Before |
| 7/1/2005 | DRI | Horgan | Demoted to reserve roster | | | Before |
| 7/1/2005 | DRI | Koch | Demoted to reserve roster | | | Before |
| 7/1/2005 | DRI | Koch | Promoted to active roster | | | Before |
| 7/1/2005 | DRI | Larson | Demoted to reserve roster | | | Before |
| 7/1/2005 | DRI | Levine | Promoted to active roster | | | Before |
| 7/1/2005 | DRI | Matthews | Demoted to reserve roster | | | Before |
| 7/1/2005 | DRI | Raines | Demoted to reserve roster | | | Before |
| 7/1/2005 | DRI | Sele | Promoted to active roster | | | Before |
| 7/1/2005 | DRI | Sturtze | Promoted to active roster | | | Before |
| 7/1/2005 | DRI | Stynes | Promoted to active roster | | | Before |
| 7/1/2005 | DRI | Valent | Demoted to reserve roster | | | Before |
| 7/1/2005 | KAN | Aquino | Demoted to reserve roster | | | Before |
| 7/1/2005 | KAN | Bell | Demoted to reserve roster | | | Before |
| 7/1/2005 | KAN | Borkowski | Promoted to active roster | | | Before |
| 7/1/2005 | KAN | Franco | Demoted to reserve roster | | | Before |
| 7/1/2005 | KAN | Gonzalez | Demoted to reserve roster | | | Before |
| 7/1/2005 | KAN | Gonzalez | Promoted to active roster | | | Before |
| 7/1/2005 | KAN | Hollandsworth | Promoted to active roster | | | Before |
| 7/1/2005 | KAN | Lamb | Promoted to active roster | | | Before |
| 7/1/2005 | KAN | Miller | Demoted to reserve roster | | | Before |
| 7/1/2005 | KAN | Redman | Demoted to reserve roster | | | Before |
| 7/1/2005 | KAN | Remlinger | Promoted to active roster | | | Before |
| 7/1/2005 | PEA | Carroll | Promoted to active roster | | | Before |
| 7/1/2005 | PEA | Cintron | Demoted to reserve roster | | | Before |
| 7/1/2005 | PIN | Everett | Demoted to reserve roster | | | Before |
| 7/1/2005 | PIN | Miller | Promoted to active roster | | | Before |
| 7/1/2005 | PIN | Nixon | Promoted to active roster | | | Before |
| 7/1/2005 | PIN | Rodriguez | Demoted to reserve roster | | | Before |
| 7/1/2005 | PIN | Youkilis | Demoted to reserve roster | | | Before |
| 7/1/2005 | PIN | Young | Promoted to active roster | | | Before |
| 7/1/2005 | SKT | Adams | Promoted to active roster | | | Before |
| 7/1/2005 | SKT | Biddle | Promoted to active roster | | | Before |
| 7/1/2005 | SKT | Gonzalez | Demoted to reserve roster | | | Before |
| 7/1/2005 | SKT | Ligtenberg | Promoted to active roster | | | Before |
| 7/1/2005 | SKT | Mendoza | Demoted to reserve roster | | | Before |
| 7/1/2005 | SKT | Obermueller | Demoted to reserve roster | | | Before |
| 7/1/2005 | SKT | Taguchi | Demoted to reserve roster | | | Before |
| 7/1/2005 | SKT | Trachsel | Promoted to active roster | | | Before |
| 7/5/2005 | IRI | Brazelton | Placed on disabled list | | 7/1/2005 | Before |
| 7/5/2005 | IRI | May | Promoted to active roster | | | Before |
| 7/5/2005 | PEA | Benson | Placed on disabled list | | 7/2/2005 | Before |
| 7/5/2005 | PEA | Erstad | Placed on disabled list | | 7/4/2005 | Before |
| 7/5/2005 | PEA | Morneau | Promoted to active roster | | | Before |
| 7/5/2005 | PEA | Sherrill | Promoted to active roster | | | Before |
| 7/6/2005 | PIN | Youkilis | Promoted to active roster | | | Before |
| 7/6/2005 | PIN | Young | Demoted to reserve roster | | | Before |
| 7/7/2005 | B C | Brocail | Promoted to active roster | | | Before |
| 7/7/2005 | B C | Bush | Promoted to active roster | | | Before |
| 7/7/2005 | B C | Reyes | Demoted to reserve roster | | | Before |
| 7/7/2005 | B C | Washburn | Demoted to reserve roster | | | Before |
| 7/7/2005 | BAN | Jimenez | Demoted to reserve roster | | | Before |
| 7/7/2005 | BAN | Nageotte | Promoted to active roster | | | Before |
| 7/7/2005 | IRI | Brazelton | Activated from disabled list | | | Before |
| 7/7/2005 | IRI | May | Demoted to reserve roster | | | Before |
| 7/7/2005 | PEA | Benson | Activated from disabled list | | | Before |
| 7/7/2005 | PEA | Carroll | Demoted to reserve roster | | | Before |
| 7/7/2005 | PEA | Cintron | Promoted to active roster | | | Before |
| 7/7/2005 | PEA | Erstad | Activated from disabled list | | | Before |
| 7/7/2005 | PEA | Erstad | Demoted to reserve roster | | | Before |
| 7/7/2005 | PEA | Sherrill | Demoted to reserve roster | | | Before |
| 7/7/2005 | PIN | Everett | Promoted to active roster | | | Before |
| 7/7/2005 | PIN | Hafner | Demoted to reserve roster | | | Before |
| 7/7/2005 | PIN | Jacobsen | Promoted to active roster | | | Before |
| 7/7/2005 | PIN | Logan | Demoted to reserve roster | | | Before |
| 7/7/2005 | PIN | Nixon | Demoted to reserve roster | | | Before |
| 7/7/2005 | PIN | Reese | Promoted to active roster | | | Before |
| 7/7/2005 | SCO | Lewis | Demoted to reserve roster | | | Before |
| 7/7/2005 | SCO | Wells | Promoted to active roster | | | Before |
| 7/7/2005 | SKT | Adams | Demoted to reserve roster | | | Before |
| 7/7/2005 | SKT | Adams | Promoted to active roster | | | Before |
| 7/7/2005 | SKT | D'Amico | Promoted to active roster | | | Before |
| 7/7/2005 | SKT | Gonzalez | Demoted to reserve roster | | | Before |
| 7/7/2005 | SKT | Gonzalez | Promoted to active roster | | | Before |
| 7/7/2005 | SKT | Ishii | Demoted to reserve roster | | | Before |
| 7/7/2005 | SKT | Majewski | Demoted to reserve roster | | | Before |
| 7/7/2005 | SKT | Majewski | Promoted to active roster | | | Before |
| 7/7/2005 | SKT | Obermueller | Promoted to active roster | | | Before |
| 7/7/2005 | SKT | Olerud | Promoted to active roster | | | Before |
| 7/7/2005 | SKT | Santos | Demoted to reserve roster | | | Before |
| 7/7/2005 | SKT | Seo | Demoted to reserve roster | | | Before |
| 7/7/2005 | SKT | Seo | Promoted to active roster | | | Before |
| 7/7/2005 | SKT | Sierra | Demoted to reserve roster | | | Before |
| 7/7/2005 | SKT | Taguchi | Promoted to active roster | | | Before |
| 7/7/2005 | SKT | Zeile | Demoted to reserve roster | | | Before |
| 7/14/2005 | B C | Bush | Demoted to reserve roster | | | Before |
| 7/14/2005 | B C | Harper | Demoted to reserve roster | | | Before |
| 7/14/2005 | B C | Lowe | Demoted to reserve roster | | | Before |
| 7/14/2005 | B C | Ramirez | Promoted to active roster | | | Before |
| 7/14/2005 | B C | Reyes | Promoted to active roster | | | Before |
| 7/14/2005 | B C | Washburn | Promoted to active roster | | | Before |
| 7/14/2005 | BAN | Brazell | Promoted to active roster | | | Before |
| 7/14/2005 | BAN | Everett | Demoted to reserve roster | | | Before |
| 7/14/2005 | BAN | Everett | Promoted to active roster | | | Before |
| 7/14/2005 | BAN | Fullmer | Demoted to reserve roster | | | Before |
| 7/14/2005 | BAN | Gonzalez | Promoted to active roster | | | Before |
| 7/14/2005 | BAN | Guzman | Promoted to active roster | | | Before |
| 7/14/2005 | BAN | Wilson | Demoted to reserve roster | | | Before |
| 7/14/2005 | BAN | Wilson | Promoted to active roster | | | Before |
| 7/14/2005 | DRI | Castillo | Promoted to active roster | | | Before |
| 7/14/2005 | DRI | Cora | Demoted to reserve roster | | | Before |
| 7/14/2005 | DRI | Cora | Promoted to active roster | | | Before |
| 7/14/2005 | DRI | Green | Demoted to reserve roster | | | Before |
| 7/14/2005 | DRI | Larson | Promoted to active roster | | | Before |
| 7/14/2005 | DRI | Stynes | Demoted to reserve roster | | | Before |
| 7/14/2005 | KAN | Franco | Promoted to active roster | | | Before |
| 7/14/2005 | KAN | Gonzalez | Demoted to reserve roster | | | Before |
| 7/14/2005 | KAN | Mesa | Demoted to reserve roster | | | Before |
| 7/14/2005 | KAN | Sanchez | Demoted to reserve roster | | | Before |
| 7/14/2005 | KAN | Thomas | Promoted to active roster | | | Before |
| 7/14/2005 | PEA | Burnett | Demoted to reserve roster | | | Before |
| 7/14/2005 | PEA | Erstad | Promoted to active roster | | | Before |
| 7/14/2005 | PEA | Halladay | Demoted to reserve roster | | | Before |
| 7/14/2005 | PEA | Halladay | Promoted to active roster | | | Before |
| 7/14/2005 | PEA | Morneau | Demoted to reserve roster | | | Before |
| 7/14/2005 | PEA | Pineiro | Promoted to active roster | | | Before |
| 7/14/2005 | PIN | Dempster | Promoted to active roster | | | Before |
| 7/14/2005 | PIN | Everett | Demoted to reserve roster | | | Before |
| 7/14/2005 | PIN | Logan | Promoted to active roster | | | Before |
| 7/14/2005 | PIN | Nixon | Promoted to active roster | | | Before |
| 7/14/2005 | PIN | Qualls | Demoted to reserve roster | | | Before |
| 7/14/2005 | PIN | Reese | Demoted to reserve roster | | | Before |
| 7/14/2005 | PIN | Youkilis | Demoted to reserve roster | | | Before |
| 7/14/2005 | PIN | Young | Promoted to active roster | | | Before |
| 7/14/2005 | SCO | Gonzalez,E | Promoted to active roster | | | Before |
| 7/14/2005 | SCO | Lopez,R | Demoted to reserve roster | | | Before |
| 7/14/2005 | SCO | Monroe | Demoted to reserve roster | | | Before |
| 7/14/2005 | SCO | Sizemore | Promoted to active roster | | | Before |
| 7/14/2005 | SKT | Adams | Demoted to reserve roster | | | Before |
| 7/14/2005 | SKT | D'Amico | Demoted to reserve roster | | | Before |
| 7/14/2005 | SKT | Gonzalez | Promoted to active roster | | | Before |
| 7/14/2005 | SKT | Seo | Promoted to active roster | | | Before |
| 7/14/2005 | SKT | Sierra | Promoted to active roster | | | Before |
| 7/15/2005 | SID | Church | Promoted to active roster | | | Before |
| 7/16/2005 | SID | Tiffee | Promoted to active roster | | | Before |
| 7/18/2005 | IRI | Harris | Promoted to active roster | | | Before |
| 7/18/2005 | SKT | Zeile | Promoted to active roster | | | Before |
| 7/19/2005 | PIN | Cash | Promoted to active roster | | | Before |
| 7/19/2005 | PIN | Dempster | Demoted to reserve roster | | | Before |
| 7/19/2005 | PIN | Hafner | Promoted to active roster | | | Before |
| 7/19/2005 | PIN | Hatteberg | Demoted to reserve roster | | | Before |
| 7/19/2005 | PIN | Hatteberg | Promoted to active roster | | | Before |
| 7/19/2005 | PIN | Jacobsen | Demoted to reserve roster | | | Before |
| 7/19/2005 | PIN | Logan | Demoted to reserve roster | | | Before |
| 7/19/2005 | PIN | Qualls | Promoted to active roster | | | Before |
| 7/19/2005 | PIN | Reese | Promoted to active roster | | | Before |
| 7/19/2005 | PIN | Rodriguez | Promoted to active roster | | | Before |
| 7/19/2005 | PIN | Torrealba | Demoted to reserve roster | | | Before |
| 7/19/2005 | PIN | Wakefield | Demoted to reserve roster | | | Before |
| 7/19/2005 | PIN | Youkilis | Promoted to active roster | | | Before |
| 7/19/2005 | PIN | Young | Demoted to reserve roster | | | Before |
| 7/19/2005 | SID | Church | Demoted to reserve roster | | | Before |
| 7/19/2005 | SID | Tiffee | Demoted to reserve roster | | | Before |
| 7/20/2005 | BAN | Bako | Released | | | Before |
| 7/20/2005 | BAN | Blum | Demoted to reserve roster | | | Before |
| 7/20/2005 | BAN | Garcia | Signed | | | Before |
| 7/20/2005 | BAN | Glanville | Signed | | | Before |
| 7/20/2005 | BAN | Guzman | Released | | | Before |
| 7/20/2005 | BAN | HELLING | Released | | | Before |
| 7/20/2005 | BAN | Krynzel | Released | | | Before |
| 7/20/2005 | BAN | Paul | Signed | | | Before |
| 7/20/2005 | BAN | Williams | Released | | | Before |
| 7/20/2005 | BAN | Wilson | Demoted to reserve roster | | | Before |
| 7/20/2005 | BAN | Wise | Signed | | | Before |
| 7/20/2005 | KAN | Bell | Promoted to active roster | | | Before |
| 7/20/2005 | KAN | Harikkala | Demoted to reserve roster | | | Before |
| 7/20/2005 | PEA | Carroll | Promoted to active roster | | | Before |
| 7/20/2005 | PEA | Halladay | Promoted to active roster | | | Before |
| 7/20/2005 | PEA | Klesko | Demoted to reserve roster | | | Before |
| 7/20/2005 | PEA | Vazquez | Demoted to reserve roster | | | Before |
| 7/20/2005 | SCO | Gonzalez,E | Demoted to reserve roster | | | Before |
| 7/20/2005 | SCO | Lopez,R | Promoted to active roster | | | Before |
| 7/20/2005 | SKT | Biddle | Demoted to reserve roster | | | Before |
| 7/20/2005 | SKT | Majewski | Promoted to active roster | | | Before |
| 7/20/2005 | SKT | Santos | Promoted to active roster | | | Before |
| 7/20/2005 | SKT | Seo | Demoted to reserve roster | | | Before |
| 7/20/2005 | SKT | Sierra | Demoted to reserve roster | | | Before |
| 7/20/2005 | SKT | Zeile | Demoted to reserve roster | | | Before |
| 7/21/2005 | PIN | Young | Promoted to active roster | | | Before |
| 7/22/2005 | IRI | Harris | Demoted to reserve roster | | | Before |
| 7/22/2005 | PHO | Feliz | Promoted to active roster | | | Before |
| 7/25/2005 | B C | Brocail | Demoted to reserve roster | | | Before |
| 7/25/2005 | B C | Camp | Promoted to active roster | | | Before |
| 7/25/2005 | B C | Osuna | Promoted to active roster | | | Before |
| 7/25/2005 | B C | Tadano | Demoted to reserve roster | | | Before |
| 7/27/2005 | B C | Bush | Promoted to active roster | | | Before |
| 7/27/2005 | B C | Dellucci | Promoted to active roster | | | Before |
| 7/27/2005 | B C | Lowe | Promoted to active roster | | | Before |
| 7/27/2005 | B C | Martinez | Demoted to reserve roster | | | Before |
| 7/27/2005 | B C | Reyes | Demoted to reserve roster | | | Before |
| 7/27/2005 | B C | Washburn | Demoted to reserve roster | | | Before |
| 7/27/2005 | BAN | Downs | Signed | | | Before |
| 7/27/2005 | BAN | Everett | Demoted to reserve roster | | | Before |
| 7/27/2005 | IRI | May | Promoted to active roster | | | Before |
| 7/27/2005 | IRI | Sabathia | Demoted to reserve roster | | | Before |
| 7/27/2005 | KAN | Anderson | Demoted to reserve roster | | | Before |
| 7/27/2005 | KAN | Hernandez | Demoted to reserve roster | | | Before |
| 7/27/2005 | KAN | Hollandsworth | Demoted to reserve roster | | | Before |
| 7/27/2005 | KAN | Mesa | Demoted to reserve roster | | | Before |
| 7/27/2005 | KAN | Mesa | Promoted to active roster | | | Before |
| 7/27/2005 | KAN | Miller | Promoted to active roster | | | Before |
| 7/27/2005 | KAN | Offerman | Promoted to active roster | | | Before |
| 7/27/2005 | KAN | Redman | Promoted to active roster | | | Before |
| 7/27/2005 | PEA | Carroll | Demoted to reserve roster | | | Before |
| 7/27/2005 | PEA | Morneau | Promoted to active roster | | | Before |
| 7/27/2005 | PEA | Pineiro | Demoted to reserve roster | | | Before |
| 7/27/2005 | PEA | Vazquez | Promoted to active roster | | | Before |
| 7/27/2005 | PIN | Catalanotto | Demoted to reserve roster | | | Before |
| 7/27/2005 | PIN | Dempster | Promoted to active roster | | | Before |
| 7/27/2005 | PIN | Everett | Promoted to active roster | | | Before |
| 7/27/2005 | PIN | Logan | Promoted to active roster | | | Before |
| 7/27/2005 | PIN | Nixon | Demoted to reserve roster | | | Before |
| 7/27/2005 | PIN | Rogers | Demoted to reserve roster | | | Before |
| 7/27/2005 | PIN | Youkilis | Demoted to reserve roster | | | Before |
| 7/27/2005 | SCO | Monroe | Promoted to active roster | | | Before |
| 7/27/2005 | SCO | Pickering | Demoted to reserve roster | | | Before |
| 7/27/2005 | SID | Bruney | Promoted to active roster | | | Before |
| 7/27/2005 | SID | Williams | Demoted to reserve roster | | | Before |
| 7/27/2005 | SKT | Ishii | Promoted to active roster | | | Before |
| 7/27/2005 | SKT | Ligtenberg | Demoted to reserve roster | | | Before |
| 7/27/2005 | SKT | Lima | Demoted to reserve roster | | | Before |
| 7/27/2005 | SKT | Mendoza | Promoted to active roster | | | Before |
| 7/27/2005 | SKT | Obermueller | Demoted to reserve roster | | | Before |
| 7/27/2005 | SKT | Seo | Promoted to active roster | | | Before |
| 7/30/2005 | PIN | Qualls | Demoted to reserve roster | | | Before |
| 7/30/2005 | PIN | Wakefield | Promoted to active roster | | | Before |
| 8/1/2005 | PIN | Cash | Demoted to reserve roster | | | Before |
| 8/1/2005 | PIN | Everett | Demoted to reserve roster | | | Before |
| 8/1/2005 | PIN | Jacobsen | Promoted to active roster | | | Before |
| 8/1/2005 | PIN | Logan | Demoted to reserve roster | | | Before |
| 8/1/2005 | PIN | Nixon | Promoted to active roster | | | Before |
| 8/1/2005 | PIN | Torrealba | Promoted to active roster | | | Before |
| 8/1/2005 | PIN | Youkilis | Promoted to active roster | | | Before |
| 8/1/2005 | PIN | Young | Demoted to reserve roster | | | Before |
| 8/2/2005 | B C | Bush | Demoted to reserve roster | | | Before |
| 8/2/2005 | B C | Camp | Demoted to reserve roster | | | Before |
| 8/2/2005 | B C | DuBose | Promoted to active roster | | | Before |
| 8/2/2005 | B C | Reyes | Promoted to active roster | | | Before |
| 8/2/2005 | DRI | Horgan | Promoted to active roster | | | Before |
| 8/2/2005 | DRI | Larson | Demoted to reserve roster | | | Before |
| 8/2/2005 | DRI | Matthews | Promoted to active roster | | | Before |
| 8/2/2005 | DRI | Willis | Demoted to reserve roster | | | Before |
| 8/2/2005 | PEA | Pineiro | Promoted to active roster | | | Before |
| 8/2/2005 | PEA | Vazquez | Demoted to reserve roster | | | Before |
| 8/2/2005 | PHO | Cruz | Demoted to reserve roster | | | Before |
| 8/2/2005 | PHO | Cruz | Promoted to active roster | | | Before |
| 8/2/2005 | PHO | Cruz | Promoted to active roster | | | Before |
| 8/2/2005 | PHO | Hendrickson | Promoted to active roster | | | Before |
| 8/2/2005 | PHO | Kim | Demoted to reserve roster | | | Before |
| 8/2/2005 | PHO | Kolb | Demoted to reserve roster | | | Before |
| 8/2/2005 | PHO | Kolb | Promoted to active roster | | | Before |
| 8/2/2005 | PHO | Meche | Demoted to reserve roster | | | Before |
| 8/2/2005 | PHO | Mitre | Promoted to active roster | | | Before |
| 8/2/2005 | PHO | Politte | Demoted to reserve roster | | | Before |
| 8/2/2005 | PHO | Reed | Demoted to reserve roster | | | Before |
| 8/2/2005 | PIN | Perez,O | Demoted to reserve roster | | | Before |
| 8/2/2005 | PIN | Rogers | Promoted to active roster | | | Before |
| 8/2/2005 | SCO | Pena | Demoted to reserve roster | | | Before |
| 8/2/2005 | SCO | Snyder | Promoted to active roster | | | Before |
| 8/2/2005 | SKT | Adams | Promoted to active roster | | | Before |
| 8/2/2005 | SKT | Lima | Promoted to active roster | | | Before |
| 8/2/2005 | SKT | Majewski | Demoted to reserve roster | | | Before |
| 8/2/2005 | SKT | Seo | Demoted to reserve roster | | | Before |
| 8/3/2005 | PEA | Closser | Promoted to active roster | | | Before |
| 8/3/2005 | PEA | Matheny | Placed on disabled list | | 8/3/2005 | Before |
| 8/4/2005 | PEA | Carroll | Promoted to active roster | | | Before |
| 8/4/2005 | PEA | Ramirez | Placed on disabled list | | 8/4/2005 | Before |
| 8/4/2005 | SCO | Pickering | Promoted to active roster | | | Before |
| 8/5/2005 | PEA | Klesko | Promoted to active roster | | | Before |
| 8/5/2005 | PEA | Lawton | Placed on disabled list | | 8/5/2005 | Before |
| 8/7/2005 | KAN | Gonzalez | Promoted to active roster | | | Before |
| 8/7/2005 | SCO | Mateo | Demoted to reserve roster | | | Before |
| 8/7/2005 | SCO | Wise | Promoted to active roster | | | Before |
| 8/8/2005 | PEA | Lawton | Activated from disabled list | | | Before |
| 8/8/2005 | PEA | Matheny | Activated from disabled list | | | Before |
| 8/8/2005 | PEA | Ramirez | Activated from disabled list | | | Before |
| 8/9/2005 | B C | DaVanon | Demoted to reserve roster | | | Before |
| 8/9/2005 | B C | Martinez | Promoted to active roster | | | Before |
| 8/9/2005 | PEA | Carroll | Demoted to reserve roster | | | Before |
| 8/9/2005 | PEA | Klesko | Demoted to reserve roster | | | Before |
| 8/9/2005 | PEA | Miller | Demoted to reserve roster | | | Before |
| 8/9/2005 | PEA | Pineiro | Demoted to reserve roster | | | Before |
| 8/9/2005 | PEA | Vazquez | Promoted to active roster | | | Before |
| 8/9/2005 | PHO | Bautista,D | Promoted to active roster | | | Before |
| 8/9/2005 | PHO | Gaudin | Demoted to reserve roster | | | Before |
| 8/9/2005 | PHO | Kim | Promoted to active roster | | | Before |
| 8/9/2005 | PHO | Kolb | Promoted to active roster | | | Before |
| 8/9/2005 | PHO | Upton | Demoted to reserve roster | | | Before |
| 8/9/2005 | PHO | Vargas | Demoted to reserve roster | | | Before |
| 8/9/2005 | PHO | Vargas | Promoted to active roster | | | Before |
| 8/9/2005 | PHO | Williams | Demoted to reserve roster | | | Before |
| 8/9/2005 | PHO | Williams | Promoted to active roster | | | Before |
| 8/9/2005 | PHO | Zambrano | Demoted to reserve roster | | | Before |
| 8/9/2005 | SKT | Adams | Demoted to reserve roster | | | Before |
| 8/9/2005 | SKT | Biddle | Promoted to active roster | | | Before |
| 8/9/2005 | SKT | Ligtenberg | Promoted to active roster | | | Before |
| 8/9/2005 | SKT | Lima | Demoted to reserve roster | | | Before |
| 8/9/2005 | SKT | Mendoza | Demoted to reserve roster | | | Before |
| 8/9/2005 | SKT | Seo | Promoted to active roster | | | Before |
| 8/9/2005 | VIP | Bauer | Demoted to reserve roster | | | Before |
| 8/9/2005 | VIP | Howry | Promoted to active roster | | | Before |
| 8/9/2005 | VIP | Newhan | Demoted to reserve roster | | | Before |
| 8/9/2005 | VIP | Sanchez | Demoted to reserve roster | | | Before |
| 8/9/2005 | VIP | Sanchez | Promoted to active roster | | | Before |
| 8/9/2005 | VIP | Utley | Promoted to active roster | | | Before |
| 8/11/2005 | VIP | Bauer | Promoted to active roster | | | Before |
| 8/12/2005 | PEA | Klesko | Promoted to active roster | | | Before |
| 8/14/2005 | PIN | Everett | Demoted to reserve roster | | | Before |
| 8/14/2005 | PIN | Everett | Promoted to active roster | | | Before |
| 8/14/2005 | PIN | McEwing | Demoted to reserve roster | | | Before |
| 8/14/2005 | PIN | McEwing | Promoted to active roster | | | Before |
| 8/15/2005 | B C | Brocail | Promoted to active roster | | | Before |
| 8/15/2005 | B C | Bush | Promoted to active roster | | | Before |
| 8/15/2005 | B C | DaVanon | Promoted to active roster | | | Before |
| 8/15/2005 | B C | Dellucci | Demoted to reserve roster | | | Before |
| 8/15/2005 | B C | Dellucci | Promoted to active roster | | | Before |
| 8/15/2005 | B C | DuBose | Demoted to reserve roster | | | Before |
| 8/15/2005 | B C | Martinez | Demoted to reserve roster | | | Before |
| 8/15/2005 | B C | Martinez | Promoted to active roster | | | Before |
| 8/15/2005 | B C | Mientkiewicz | Demoted to reserve roster | | | Before |
| 8/15/2005 | B C | Mientkiewicz | Promoted to active roster | | | Before |
| 8/15/2005 | B C | Reyes | Demoted to reserve roster | | | Before |
| 8/15/2005 | IRI | Wellemeyer | Demoted to reserve roster | | | Before |
| 8/15/2005 | IRI | Wuertz | Promoted to active roster | | | Before |
| 8/15/2005 | KAN | Almanzar | Demoted to reserve roster | | | Before |
| 8/15/2005 | KAN | Anderson | Promoted to active roster | | | Before |
| 8/15/2005 | KAN | Cruz | Demoted to reserve roster | | | Before |
| 8/15/2005 | KAN | Durham | Demoted to reserve roster | | | Before |
| 8/15/2005 | KAN | Harikkala | Promoted to active roster | | | Before |
| 8/15/2005 | KAN | Hollandsworth | Promoted to active roster | | | Before |
| 8/15/2005 | KAN | Isringhausen | Demoted to reserve roster | | | Before |
| 8/15/2005 | KAN | Mercker | Demoted to reserve roster | | | Before |
| 8/15/2005 | KAN | Mesa | Promoted to active roster | | | Before |
| 8/15/2005 | KAN | Munro | Promoted to active roster | | | Before |
| 8/15/2005 | KAN | Ortiz | Promoted to active roster | | | Before |
| 8/15/2005 | KAN | Remlinger | Demoted to reserve roster | | | Before |
| 8/15/2005 | KAN | Sanchez | Promoted to active roster | | | Before |
| 8/15/2005 | KAN | Thomas | Demoted to reserve roster | | | Before |
| 8/15/2005 | PEA | Klesko | Demoted to reserve roster | | | Before |
| 8/15/2005 | PEA | Pineiro | Promoted to active roster | | | Before |
| 8/15/2005 | PEA | Vazquez | Demoted to reserve roster | | | Before |
| 8/15/2005 | PHO | Kubel | Promoted to active roster | | | Before |
| 8/15/2005 | PHO | LaRoche | Demoted to reserve roster | | | Before |
| 8/15/2005 | PHO | Reed | Demoted to reserve roster | | | Before |
| 8/15/2005 | PHO | Reed | Promoted to active roster | | | Before |
| 8/15/2005 | PIN | Arroyo | Demoted to reserve roster | | | Before |
| 8/15/2005 | PIN | Cash | Promoted to active roster | | | Before |
| 8/15/2005 | PIN | Everett | Promoted to active roster | | | Before |
| 8/15/2005 | PIN | Nixon | Demoted to reserve roster | | | Before |
| 8/15/2005 | PIN | Perez,O | Promoted to active roster | | | Before |
| 8/15/2005 | PIN | Torrealba | Demoted to reserve roster | | | Before |
| 8/15/2005 | PIN | Youkilis | Demoted to reserve roster | | | Before |
| 8/15/2005 | PIN | Young | Promoted to active roster | | | Before |
| 8/15/2005 | SCO | Chen | Promoted to active roster | | | Before |
| 8/15/2005 | SCO | Clement | Demoted to reserve roster | | | Before |
| 8/15/2005 | SCO | Izturis | Demoted to reserve roster | | | Before |
| 8/15/2005 | SCO | Lewis | Released | | | Before |
| 8/15/2005 | SCO | Olson | Signed | | | Before |
| 8/15/2005 | SCO | Olson | Demoted to reserve roster | | | Before |
| 8/15/2005 | SCO | Olson | Promoted to active roster | | | Before |
| 8/15/2005 | SCO | Pickering | Promoted to active roster | | | Before |
| 8/15/2005 | SID | Halsey | Promoted to active roster | | | Before |
| 8/15/2005 | SID | Perez | Demoted to reserve roster | | | Before |
| 8/15/2005 | SID | Perez | Promoted to active roster | | | Before |
| 8/15/2005 | SID | Westbrook | Demoted to reserve roster | | | Before |
| 8/15/2005 | SID | Westbrook | Promoted to active roster | | | Before |
| 8/15/2005 | SID | Westbrook | Demoted to reserve roster | | | Before |
| 8/15/2005 | SKT | Adams | Promoted to active roster | | | Before |
| 8/15/2005 | SKT | Gonzalez | Demoted to reserve roster | | | Before |
| 8/15/2005 | SKT | Gonzalez,L | Demoted to reserve roster | | | Before |
| 8/15/2005 | SKT | Lima | Promoted to active roster | | | Before |
| 8/15/2005 | SKT | Seo | Demoted to reserve roster | | | Before |
| 8/15/2005 | SKT | Sierra | Promoted to active roster | | | Before |
| 8/19/2005 | B C | Flaherty | Promoted to active roster | | | Before |
| 8/19/2005 | SKT | Kata | Promoted to active roster | | | Before |
| 8/20/2005 | B C | Brocail | Demoted to reserve roster | | | Before |
| 8/20/2005 | B C | Bush | Demoted to reserve roster | | | Before |
| 8/20/2005 | B C | DaVanon | Demoted to reserve roster | | | Before |
| 8/20/2005 | B C | DuBose | Promoted to active roster | | | Before |
| 8/20/2005 | B C | Flaherty | Demoted to reserve roster | | | Before |
| 8/20/2005 | B C | Gibbons | Demoted to reserve roster | | | Before |
| 8/20/2005 | B C | Gibbons | Promoted to active roster | | | Before |
| 8/20/2005 | B C | Harper | Promoted to active roster | | | Before |
| 8/20/2005 | B C | Lowe | Demoted to reserve roster | | | Before |
| 8/20/2005 | B C | Reyes | Promoted to active roster | | | Before |
| 8/20/2005 | B C | Riske | Demoted to reserve roster | | | Before |
| 8/20/2005 | B C | Tadano | Promoted to active roster | | | Before |
| 8/20/2005 | IRI | Brazelton | Demoted to reserve roster | | | Before |
| 8/20/2005 | IRI | Sabathia | Promoted to active roster | | | Before |
| 8/20/2005 | PIN | Arroyo | Promoted to active roster | | | Before |
| 8/20/2005 | PIN | Cash | Demoted to reserve roster | | | Before |
| 8/20/2005 | PIN | Jacobsen | Demoted to reserve roster | | | Before |
| 8/20/2005 | PIN | Logan | Promoted to active roster | | | Before |
| 8/20/2005 | PIN | Qualls | Promoted to active roster | | | Before |
| 8/20/2005 | PIN | Rodriguez | Demoted to reserve roster | | | Before |
| 8/20/2005 | PIN | Rogers | Demoted to reserve roster | | | Before |
| 8/20/2005 | PIN | Torrealba | Promoted to active roster | | | Before |
| 8/20/2005 | SCO | Clement | Promoted to active roster | | | Before |
| 8/20/2005 | SCO | Lopez,R | Demoted to reserve roster | | | Before |
| 8/20/2005 | SCO | Pickering | Demoted to reserve roster | | | Before |
| 8/20/2005 | SID | Perez | Demoted to reserve roster | | | Before |
| 8/20/2005 | SID | Westbrook | Promoted to active roster | | | Before |
| 8/20/2005 | VIP | Bauer | Demoted to reserve roster | | | Before |
| 8/20/2005 | VIP | Hudson | Promoted to active roster | | | Before |
| 8/20/2005 | VIP | Penny | Demoted to reserve roster | | | Before |
| 8/22/2005 | DRI | Castillo | Demoted to reserve roster | | | Before |
| 8/22/2005 | DRI | Dessens | Demoted to reserve roster | | | Before |
| 8/22/2005 | DRI | Fassero | Demoted to reserve roster | | | Before |
| 8/22/2005 | DRI | Galarraga | Promoted to active roster | | | Before |
| 8/22/2005 | DRI | Green | Promoted to active roster | | | Before |
| 8/22/2005 | DRI | Koch | Promoted to active roster | | | Before |
| 8/22/2005 | DRI | Larson | Promoted to active roster | | | Before |
| 8/22/2005 | DRI | Merloni | Demoted to reserve roster | | | Before |
| 8/22/2005 | DRI | Stairs | Demoted to reserve roster | | | Before |
| 8/22/2005 | DRI | Stairs | Promoted to active roster | | | Before |
| 8/22/2005 | DRI | Sturtze | Demoted to reserve roster | | | Before |
| 8/22/2005 | DRI | Willis | Promoted to active roster | | | Before |
| 8/22/2005 | KAN | Hollandsworth | Demoted to reserve roster | | | Before |
| 8/22/2005 | KAN | Isringhausen | Promoted to active roster | | | Before |
| 8/22/2005 | KAN | Leiter | Demoted to reserve roster | | | Before |
| 8/22/2005 | PEA | Pineiro | Demoted to reserve roster | | | Before |
| 8/22/2005 | PEA | Vazquez | Promoted to active roster | | | Before |
| 8/22/2005 | SID | Church | Promoted to active roster | | | Before |
| 8/24/2005 | PHO | Cantu | Promoted to active roster | | | Before |
| 8/24/2005 | PHO | Feliz | Placed on disabled list | | 8/24/2005 | Before |
| 8/24/2005 | PHO | Kielty | Placed on disabled list | | 8/24/2005 | Before |
| 8/24/2005 | PHO | LaRoche | Promoted to active roster | | | Before |
| 8/25/2005 | SCO | Izturis | Promoted to active roster | | | Before |
| 8/26/2005 | PEA | Matheny | Placed on disabled list | | 8/26/2005 | Before |
| 8/26/2005 | PEA | Miller | Promoted to active roster | | | Before |
| 8/27/2005 | IRI | Balfour | Promoted to active roster | | | Before |
| 8/27/2005 | IRI | Seanez | Demoted to reserve roster | | | Before |
| 8/28/2005 | B C | Brocail | Promoted to active roster | | | Before |
| 8/28/2005 | B C | Bush | Promoted to active roster | | | Before |
| 8/28/2005 | B C | Camp | Promoted to active roster | | | Before |
| 8/28/2005 | B C | DaVanon | Promoted to active roster | | | Before |
| 8/28/2005 | B C | DuBose | Demoted to reserve roster | | | Before |
| 8/28/2005 | B C | DuBose | Promoted to active roster | | | Before |
| 8/28/2005 | B C | Flaherty | Promoted to active roster | | | Before |
| 8/28/2005 | B C | Harvey | Promoted to active roster | | | Before |
| 8/28/2005 | B C | Lowe | Promoted to active roster | | | Before |
| 8/28/2005 | B C | Mientkiewicz | Promoted to active roster | | | Before |
| 8/28/2005 | B C | Reyes | Demoted to reserve roster | | | Before |
| 8/28/2005 | B C | Reyes | Promoted to active roster | | | Before |
| 8/28/2005 | B C | Riske | Promoted to active roster | | | Before |
| 8/28/2005 | B C | Washburn | Promoted to active roster | | | Before |
| 8/28/2005 | IRI | Atchison | Demoted to reserve roster | | | Before |
| 8/28/2005 | IRI | Seay | Promoted to active roster | | | Before |
| 8/28/2005 | KAN | Almanzar | Released | | | Before |
| 8/28/2005 | KAN | Aquino | Promoted to active roster | | | Before |
| 8/28/2005 | KAN | Durham | Demoted to reserve roster | | | Before |
| 8/28/2005 | KAN | Durham | Promoted to active roster | | | Before |
| 8/28/2005 | KAN | Hansen | Signed | | | Before |
| 8/28/2005 | KAN | Harville | Signed | | | Before |
| 8/28/2005 | KAN | Lamb | Released | | | Before |
| 8/28/2005 | PEA | Carroll | Promoted to active roster | | | Before |
| 8/28/2005 | PEA | Freeman | Promoted to active roster | | | Before |
| 8/28/2005 | PEA | Klesko | Promoted to active roster | | | Before |
| 8/28/2005 | PEA | Matheny | Activated from disabled list | | | Before |
| 8/28/2005 | PEA | Pineiro | Promoted to active roster | | | Before |
| 8/28/2005 | PEA | Sherrill | Promoted to active roster | | | Before |
| 8/28/2005 | PEA | Vazquez | Demoted to reserve roster | | | Before |
| 8/28/2005 | PHO | Feliz | Activated from disabled list | | | Before |
| 8/28/2005 | PHO | Kielty | Activated from disabled list | | | Before |
| 8/28/2005 | PIN | Aardsma | Promoted to active roster | | | Before |
| 8/28/2005 | PIN | Alvarez | Promoted to active roster | | | Before |
| 8/28/2005 | PIN | Cash | Promoted to active roster | | | Before |
| 8/28/2005 | PIN | Catalanotto | Promoted to active roster | | | Before |
| 8/28/2005 | PIN | Jacobsen | Promoted to active roster | | | Before |
| 8/28/2005 | PIN | Nixon | Promoted to active roster | | | Before |
| 8/28/2005 | PIN | Rodriguez | Promoted to active roster | | | Before |
| 8/28/2005 | PIN | Rogers | Promoted to active roster | | | Before |
| 8/28/2005 | PIN | Sanchez | Promoted to active roster | | | Before |
| 8/28/2005 | PIN | Youkilis | Promoted to active roster | | | Before |
| 8/28/2005 | SCO | Chen | Demoted to reserve roster | | | Before |
| 8/28/2005 | SCO | Durbin | Promoted to active roster | | | Before |
| 8/28/2005 | SCO | Flores | Promoted to active roster | | | Before |
| 8/28/2005 | SCO | Gonzalez,E | Promoted to active roster | | | Before |
| 8/28/2005 | SCO | Lopez,R | Promoted to active roster | | | Before |
| 8/28/2005 | SCO | Mateo | Promoted to active roster | | | Before |
| 8/28/2005 | SCO | Pena | Promoted to active roster | | | Before |
| 8/28/2005 | SCO | Perez,A | Promoted to active roster | | | Before |
| 8/28/2005 | SCO | Pickering | Promoted to active roster | | | Before |
| 8/28/2005 | SCO | Waechter | Promoted to active roster | | | Before |
| 8/28/2005 | SID | Diaz | Promoted to active roster | | | Before |
| 8/28/2005 | SID | Gomes | Promoted to active roster | | | Before |
| 8/28/2005 | SID | Gosling | Promoted to active roster | | | Before |
| 8/28/2005 | SID | Perez | Promoted to active roster | | | Before |
| 8/28/2005 | SID | Shelton | Promoted to active roster | | | Before |
| 8/28/2005 | SID | Tiffee | Promoted to active roster | | | Before |
| 8/28/2005 | SID | Villarreal | Promoted to active roster | | | Before |
| 8/28/2005 | SKT | Biddle | Demoted to reserve roster | | | Before |
| 8/28/2005 | SKT | Gonzalez | Promoted to active roster | | | Before |
| 8/28/2005 | SKT | Gonzalez,L | Promoted to active roster | | | Before |
| 8/28/2005 | SKT | Kata | Demoted to reserve roster | | | Before |
| 8/28/2005 | SKT | Lima | Demoted to reserve roster | | | Before |
| 8/28/2005 | SKT | Obermueller | Promoted to active roster | | | Before |
| 8/28/2005 | SKT | Taguchi | Demoted to reserve roster | | | Before |
| 8/28/2005 | VIP | Atkins | Promoted to active roster | | | Before |
| 8/28/2005 | VIP | Bauer | Promoted to active roster | | | Before |
| 8/28/2005 | VIP | Cabrera | Promoted to active roster | | | Before |
| 8/28/2005 | VIP | Correia | Promoted to active roster | | | Before |
| 8/28/2005 | VIP | Hennessey | Promoted to active roster | | | Before |
| 8/28/2005 | VIP | Hill | Promoted to active roster | | | Before |
| 8/28/2005 | VIP | Hudson | Demoted to reserve roster | | | Before |
| 8/28/2005 | VIP | Pavano | Demoted to reserve roster | | | Before |
| 8/29/2005 | IRI | Harris | Promoted to active roster | | | Before |
| 9/1/2005 | KAN | Almanzar | Signed | | | Before |
| 9/1/2005 | KAN | Harville | Released | | | Before |
| 9/1/2005 | KAN | Harville | Signed | | | Before |
| 9/1/2005 | PIN | Aardsma | Demoted to reserve roster | | | Before |
| 9/1/2005 | PIN | Alvarez | Demoted to reserve roster | | | Before |
| 9/1/2005 | PIN | Dempster | Demoted to reserve roster | | | Before |
| 9/1/2005 | PIN | Sanchez | Demoted to reserve roster | | | Before |
| 9/1/2005 | SID | Figgins | Demoted to reserve roster | | | Before |
| 9/1/2005 | SID | Madson | Demoted to reserve roster | | | Before |
| 9/1/2005 | SID | Perez | Demoted to reserve roster | | | Before |
| 9/3/2005 | IRI | Brazelton | Promoted to active roster | | | Before |
| 9/3/2005 | IRI | Dubois | Promoted to active roster | | | Before |
| 9/3/2005 | IRI | Phillips | Promoted to active roster | | | Before |
| 9/3/2005 | KAN | Almanzar | Released | | | Before |
| 9/3/2005 | PHO | Gaudin | Promoted to active roster | | | Before |
| 9/3/2005 | PHO | LaRoche | Demoted to reserve roster | | | Before |
| 9/3/2005 | PHO | Reed | Promoted to active roster | | | Before |
| 9/3/2005 | PHO | Zambrano | Promoted to active roster | | | Before |
| 9/3/2005 | SCO | Cummings | Signed | | | Before |
| 9/3/2005 | SCO | Gonzalez,E | Released | | | Before |
| 9/3/2005 | SCO | Pickering | Demoted to reserve roster | | | Before |
| 9/3/2005 | SKT | Biddle | Promoted to active roster | | | Before |
| 9/3/2005 | SKT | D'Amico | Promoted to active roster | | | Before |
| 9/3/2005 | SKT | Higginson | Promoted to active roster | | | Before |
| 9/3/2005 | SKT | Kata | Promoted to active roster | | | Before |
| 9/3/2005 | SKT | Lima | Promoted to active roster | | | Before |
| 9/3/2005 | SKT | Majewski | Promoted to active roster | | | Before |
| 9/3/2005 | SKT | Mendoza | Promoted to active roster | | | Before |
| 9/3/2005 | SKT | Seo | Promoted to active roster | | | Before |
| 9/3/2005 | SKT | Taguchi | Promoted to active roster | | | Before |
| 9/3/2005 | SKT | Zeile | Promoted to active roster | | | Before |
| 9/3/2005 | VIP | Borchard | Released | | | Before |
| 9/3/2005 | VIP | Hill | Released | | | Before |
| 9/3/2005 | VIP | Jordan | Signed | | | Before |
| 9/3/2005 | VIP | Powell | Signed | | | Before |
| 9/3/2005 | VIP | Sanchez | Released | | | Before |
| 9/3/2005 | VIP | Spivey | Signed | | | Before |
| 9/7/2005 | DRI | Castilla | Promoted to active roster | | | Before |
| 9/7/2005 | DRI | Clark | Promoted to active roster | | | Before |
| 9/7/2005 | DRI | Holliday | Promoted to active roster | | | Before |
| 9/7/2005 | DRI | Koch | Demoted to reserve roster | | | Before |
| 9/7/2005 | DRI | Levine | Promoted to active roster | | | Before |
| 9/7/2005 | DRI | Matthews | Promoted to active roster | | | Before |
| 9/7/2005 | DRI | Sele | Promoted to active roster | | | Before |
| 9/7/2005 | DRI | Sturtze | Promoted to active roster | | | Before |
| 9/7/2005 | DRI | Stynes | Promoted to active roster | | | Before |
| 9/7/2005 | PHO | Chacin | Promoted to active roster | | | Before |
| 9/7/2005 | PHO | Williams | Promoted to active roster | | | Before |
| 9/7/2005 | PIN | Aardsma | Promoted to active roster | | | Before |
| 9/7/2005 | PIN | Alvarez | Promoted to active roster | | | Before |
| 9/7/2005 | PIN | Dempster | Promoted to active roster | | | Before |
| 9/7/2005 | PIN | Sanchez | Promoted to active roster | | | Before |
| 9/7/2005 | VIP | Aguila | Signed | | | Before |
| 9/7/2005 | VIP | Bauer | Released | | | Before |
| 9/7/2005 | VIP | Bauer | Demoted to reserve roster | | | Before |
| 9/7/2005 | VIP | Cabrera | Promoted to active roster | | | Before |
| 9/7/2005 | VIP | Hudson | Promoted to active roster | | | Before |
| 9/7/2005 | VIP | Newhan | Promoted to active roster | | | Before |
| 9/7/2005 | VIP | Pavano | Promoted to active roster | | | Before |
| 9/8/2005 | VIP | Aguila | Signed | | | Before |
| 9/8/2005 | VIP | Bauer | Released | | | Before |
| 9/12/2005 | DRI | Galarraga | Released | | | Before |
| 9/12/2005 | DRI | Galarraga | Signed | | | Before |
| 9/12/2005 | DRI | Perez | Signed | | | Before |
| 9/12/2005 | PIN | Aardsma | Demoted to reserve roster | | | Before |
| 9/12/2005 | PIN | Alvarez | Demoted to reserve roster | | | Before |
| 9/12/2005 | PIN | Dempster | Demoted to reserve roster | | | Before |
| 9/12/2005 | PIN | Sanchez | Demoted to reserve roster | | | Before |
| 9/14/2005 | DRI | Galarraga | Released | | | Before |
| 9/14/2005 | PEA | Pineiro | Demoted to reserve roster | | | Before |
| 9/14/2005 | PEA | Vazquez | Promoted to active roster | | | Before |
| 9/14/2005 | SID | Madson | Promoted to active roster | | | Before |
| 9/14/2005 | SID | Perez | Promoted to active roster | | | Before |
| 9/14/2005 | SID | Williams | Promoted to active roster | | | Before |
| 9/14/2005 | SID | Willingham | Promoted to active roster | | | Before |
| 9/14/2005 | VIP | Benitez | Demoted to reserve roster | | | Before |
| 9/14/2005 | VIP | Marquis | Demoted to reserve roster | | | Before |
| 9/14/2005 | VIP | Newhan | Demoted to reserve roster | | | Before |
| 9/18/2005 | IRI | Lane | Demoted to reserve roster | | | Before |
| 9/18/2005 | IRI | Phillips | Demoted to reserve roster | | | Before |
| 9/18/2005 | IRI | Wuertz | Demoted to reserve roster | | | Before |
| 9/19/2005 | IRI | Atchison | Promoted to active roster | | | Before |
| 9/19/2005 | IRI | Seay | Demoted to reserve roster | | | Before |
| 9/19/2005 | IRI | Wellemeyer | Promoted to active roster | | | Before |
| 9/19/2005 | PEA | Benson | Demoted to reserve roster | | | Before |
| 9/19/2005 | PEA | de la Rosa | Promoted to active roster | | | Before |
| 9/19/2005 | PEA | Pineiro | Promoted to active roster | | | Before |
| 9/19/2005 | PIN | Aardsma | Promoted to active roster | | | Before |
| 9/19/2005 | PIN | Alvarez | Promoted to active roster | | | Before |
| 9/19/2005 | PIN | Dempster | Promoted to active roster | | | Before |
| 9/19/2005 | PIN | Sanchez | Promoted to active roster | | | Before |
| 9/19/2005 | SCO | Clement | Demoted to reserve roster | | | Before |
| 9/19/2005 | SCO | Durbin | Demoted to reserve roster | | | Before |
| 9/19/2005 | SCO | Izturis | Demoted to reserve roster | | | Before |
| 9/19/2005 | SCO | Perez,A | Demoted to reserve roster | | | Before |
| 9/19/2005 | SID | Diaz | Released | | | Before |
| 9/19/2005 | SID | Halter | Signed | | | Before |
| 9/23/2005 | PIN | Aardsma | Demoted to reserve roster | | | Before |
| 9/23/2005 | PIN | Alvarez | Demoted to reserve roster | | | Before |
| 9/23/2005 | PIN | Cash | Demoted to reserve roster | | | Before |
| 9/23/2005 | PIN | Catalanotto | Demoted to reserve roster | | | Before |
| 9/23/2005 | PIN | Dempster | Demoted to reserve roster | | | Before |
| 9/23/2005 | PIN | Jacobsen | Demoted to reserve roster | | | Before |
| 9/23/2005 | PIN | Logan | Demoted to reserve roster | | | Before |
| 9/23/2005 | PIN | Reese | Demoted to reserve roster | | | Before |
| 9/23/2005 | PIN | Sanchez | Demoted to reserve roster | | | Before |
| 9/23/2005 | PIN | Wakefield | Demoted to reserve roster | | | Before |
| 9/23/2005 | VIP | Hampton | Demoted to reserve roster | | | Before |
| 9/23/2005 | VIP | Howry | Demoted to reserve roster | | | Before |
| 9/23/2005 | VIP | Marquis | Promoted to active roster | | | Before |
| 9/23/2005 | VIP | Penny | Promoted to active roster | | | Before |
| 9/23/2005 | VIP | Ryan | Demoted to reserve roster | | | Before |
| 9/25/2005 | SID | Church | Demoted to reserve roster | | | Before |
| 9/25/2005 | SID | Figgins | Promoted to active roster | | | Before |
| 9/25/2005 | SID | Gomes | Demoted to reserve roster | | | Before |
| 9/25/2005 | SID | Gosling | Demoted to reserve roster | | | Before |
| 9/25/2005 | SID | Halsey | Demoted to reserve roster | | | Before |
| 9/25/2005 | SID | Halter | Demoted to reserve roster | | | Before |
| 9/25/2005 | SID | Redding | Demoted to reserve roster | | | Before |
| 9/25/2005 | SID | Shelton | Demoted to reserve roster | | | Before |
| 9/25/2005 | SID | Tiffee | Demoted to reserve roster | | | Before |
| 9/25/2005 | SID | Villarreal | Demoted to reserve roster | | | Before |
| 9/25/2005 | SID | Willingham | Demoted to reserve roster | | | Before |
| 9/25/2005 | SKT | Gonzalez | Demoted to reserve roster | | | Before |
| 9/25/2005 | SKT | Higginson | Demoted to reserve roster | | | Before |
| 9/25/2005 | SKT | Ligtenberg | Promoted to active roster | | | Before |
| 9/25/2005 | SKT | Taguchi | Promoted to active roster | | | Before |
| 9/25/2005 | SKT | Trachsel | Demoted to reserve roster | | | Before |
| 9/25/2005 | SKT | Zeile | Promoted to active roster | | | Before |
| 9/25/2005 | VIP | Aguila | Demoted to reserve roster | | | Before |
| 9/25/2005 | VIP | Atkins | Demoted to reserve roster | | | Before |
| 9/25/2005 | VIP | Benitez | Promoted to active roster | | | Before |
| 9/25/2005 | VIP | Cabrera | Demoted to reserve roster | | | Before |
| 9/25/2005 | VIP | Correia | Demoted to reserve roster | | | Before |
| 9/25/2005 | VIP | Eckstein | Demoted to reserve roster | | | Before |
| 9/25/2005 | VIP | Hampton | Promoted to active roster | | | Before |
| 9/25/2005 | VIP | Hennessey | Demoted to reserve roster | | | Before |
| 9/25/2005 | VIP | Howry | Promoted to active roster | | | Before |
| 9/25/2005 | VIP | Jordan | Demoted to reserve roster | | | Before |
| 9/25/2005 | VIP | Marquis | Demoted to reserve roster | | | Before |
| 9/25/2005 | VIP | Newhan | Promoted to active roster | | | Before |
| 9/25/2005 | VIP | Powell | Demoted to reserve roster | | | Before |
| 9/25/2005 | VIP | Ryan | Promoted to active roster | | | Before |
| 10/12/2005 | VIP | Eckstein | Promoted to active roster | | | Before |
| 10/12/2005 | VIP | Hampton | Demoted to reserve roster | | | Before |
| 10/12/2005 | VIP | Hampton | Promoted to active roster | | | Before |
| 10/12/2005 | VIP | Marquis | Promoted to active roster | | | Before |
| 10/15/2005 | VIP | Marquis | Demoted to reserve roster | | | Before |
| 10/15/2005 | VIP | Williams | Demoted to reserve roster | | | Before |
| 10/20/2005 | SCO | Contreras | Traded away | SYN | | After |
| 10/20/2005 | SCO | Contreras | Acquired via trade | SYN | | After |
| 10/20/2005 | SCO | Rolen | Traded away | SYN | | After |
| 10/20/2005 | SCO | Rolen | Acquired via trade | SYN | | After |