| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 3/31/2005 | FOR | Ohka | Acquired via trade | SCO | | After |
| 3/31/2005 | HEN | Vogelsong | Traded away | SLG | | After |
| 3/31/2005 | HEN | Williams | Acquired via trade | SLG | | After |
| 3/31/2005 | SCO | Ohka | Traded away | FOR | | After |
| 3/31/2005 | SLG | Vogelsong | Acquired via trade | HEN | | After |
| 3/31/2005 | SLG | Williams | Traded away | HEN | | After |
| 4/1/2005 | KAN | Aquino | Demoted to reserve roster | | | Before |
| 4/1/2005 | KAN | Hernandez | Promoted to active roster | | | Before |
| 4/2/2005 | KAN | Floyd | Promoted to active roster | | | Before |
| 4/2/2005 | KAN | Lamb | Demoted to reserve roster | | | Before |
| 4/3/2005 | SCO | Lewis | Demoted to reserve roster | | | Before |
| 4/4/2005 | KAN | Lamb | Promoted to active roster | | | Before |
| 4/4/2005 | KAN | Miller | Promoted to active roster | | | Before |
| 4/4/2005 | KAN | Ortiz | Demoted to reserve roster | | | Before |
| 4/4/2005 | KAN | Sanchez | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Brocail | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Camp | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Dellucci | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Dellucci | Promoted to active roster | | | Before |
| 4/6/2005 | B C | DuBose | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Flaherty | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Gibbons | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Harvey | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Harvey | Promoted to active roster | | | Before |
| 4/6/2005 | B C | Mientkiewicz | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Osuna | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Ramirez | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Reyes | Demoted to reserve roster | | | Before |
| 4/6/2005 | B C | Tadano | Demoted to reserve roster | | | Before |
| 4/7/2005 | BST | Franco | Promoted to active roster | | | Before |
| 4/7/2005 | BST | Gload | Demoted to reserve roster | | | Before |
| 4/7/2005 | COM | Cota | Promoted to active roster | | | Before |
| 4/7/2005 | COM | DeJean | Demoted to reserve roster | | | Before |
| 4/7/2005 | COM | DeJean | Promoted to active roster | | | Before |
| 4/7/2005 | COM | Elarton | Demoted to reserve roster | | | Before |
| 4/7/2005 | COM | Fossum | Promoted to active roster | | | Before |
| 4/7/2005 | COM | Jones | Demoted to reserve roster | | | Before |
| 4/7/2005 | COM | Jones | Promoted to active roster | | | Before |
| 4/7/2005 | COM | Marrero | Demoted to reserve roster | | | Before |
| 4/7/2005 | HEN | Rhodes | Promoted to active roster | | | Before |
| 4/7/2005 | HEN | Williamson | Demoted to reserve roster | | | Before |
| 4/7/2005 | PEA | Eyre | Promoted to active roster | | | Before |
| 4/7/2005 | PEA | Morneau | Demoted to reserve roster | | | Before |
| 4/7/2005 | SCO | Pickering | Promoted to active roster | | | Before |
| 4/7/2005 | SCO | Snyder | Demoted to reserve roster | | | Before |
| 4/7/2005 | SLG | Castro | Signed | | | Before |
| 4/7/2005 | SLG | Griffey | Demoted to reserve roster | | | Before |
| 4/7/2005 | SLG | House | Released | | | Before |
| 4/9/2005 | KAN | Franco | Demoted to reserve roster | | | Before |
| 4/9/2005 | KAN | Ortiz | Promoted to active roster | | | Before |
| 4/12/2005 | COM | Armas | Promoted to active roster | | | Before |
| 4/12/2005 | COM | DeJean | Promoted to active roster | | | Before |
| 4/12/2005 | COM | Elarton | Promoted to active roster | | | Before |
| 4/12/2005 | COM | Fossum | Demoted to reserve roster | | | Before |
| 4/12/2005 | COM | Haren | Demoted to reserve roster | | | Before |
| 4/12/2005 | COM | Jones | Demoted to reserve roster | | | Before |
| 4/12/2005 | COM | Loaiza | Promoted to active roster | | | Before |
| 4/12/2005 | COM | Patterson | Demoted to reserve roster | | | Before |
| 4/12/2005 | COM | Wolf | Demoted to reserve roster | | | Before |
| 4/12/2005 | COM | Marrero | Traded away | SYN | | After |
| 4/12/2005 | COM | Patterson | Acquired via trade | SYN | | After |
| 4/12/2005 | HYS | Bedard | Demoted to reserve roster | | | Before |
| 4/12/2005 | HYS | Benoit | Promoted to active roster | | | Before |
| 4/12/2005 | HYS | Lopez | Promoted to active roster | | | Before |
| 4/12/2005 | HYS | Perez | Demoted to reserve roster | | | Before |
| 4/12/2005 | HYS | Wilson | Demoted to reserve roster | | | Before |
| 4/12/2005 | HYS | Wilson | Promoted to active roster | | | Before |
| 4/12/2005 | SYN | Marrero | Acquired via trade | COM | | After |
| 4/12/2005 | SYN | Patterson | Traded away | COM | | After |
| 4/14/2005 | BST | Beltran,F | Promoted to active roster | | | Before |
| 4/14/2005 | BST | Colon | Promoted to active roster | | | Before |
| 4/14/2005 | BST | Franco | Demoted to reserve roster | | | Before |
| 4/14/2005 | BST | Guardado | Demoted to reserve roster | | | Before |
| 4/14/2005 | FOR | Ohka | Demoted to reserve roster | | | Before |
| 4/14/2005 | FOR | Pettitte | Promoted to active roster | | | Before |
| 4/14/2005 | HYS | Grimsley | Demoted to reserve roster | | | Before |
| 4/14/2005 | HYS | Hill | Demoted to reserve roster | | | Before |
| 4/14/2005 | HYS | Miller | Promoted to active roster | | | Before |
| 4/14/2005 | HYS | Perez | Promoted to active roster | | | Before |
| 4/14/2005 | HYS | Tankersley | Promoted to active roster | | | Before |
| 4/14/2005 | HYS | Woodward | Demoted to reserve roster | | | Before |
| 4/14/2005 | KAN | Ginter | Promoted to active roster | | | Before |
| 4/14/2005 | KAN | Hernandez | Demoted to reserve roster | | | Before |
| 4/14/2005 | KAN | Lamb | Demoted to reserve roster | | | Before |
| 4/14/2005 | KAN | Miller | Demoted to reserve roster | | | Before |
| 4/14/2005 | KAN | Moyer | Promoted to active roster | | | Before |
| 4/14/2005 | KAN | Sanchez | Promoted to active roster | | | Before |
| 4/14/2005 | SLG | Blanton | Promoted to active roster | | | Before |
| 4/14/2005 | SLG | Prior | Demoted to reserve roster | | | Before |
| 4/14/2005 | SLG | Vogelsong | Promoted to active roster | | | Before |
| 4/14/2005 | SLG | Wickman | Demoted to reserve roster | | | Before |
| 4/14/2005 | SYN | Cook | Demoted to reserve roster | | | Before |
| 4/14/2005 | SYN | German | Demoted to reserve roster | | | Before |
| 4/14/2005 | SYN | German | Promoted to active roster | | | Before |
| 4/14/2005 | SYN | German | Demoted to reserve roster | | | Before |
| 4/14/2005 | SYN | German | Promoted to active roster | | | Before |
| 4/14/2005 | SYN | Marrero | Promoted to active roster | | | Before |
| 4/14/2005 | SYN | Mauer | Promoted to active roster | | | Before |
| 4/14/2005 | SYN | Tsao | Demoted to reserve roster | | | Before |
| 4/14/2005 | SYN | Tsao | Promoted to active roster | | | Before |
| 4/14/2005 | SYN | Tsao | Promoted to active roster | | | Before |
| 4/14/2005 | SYN | Valentin | Demoted to reserve roster | | | Before |
| 4/14/2005 | VIP | Buehrle | Demoted to reserve roster | | | Before |
| 4/14/2005 | VIP | Buehrle | Promoted to active roster | | | Before |
| 4/14/2005 | VIP | Hudson | Demoted to reserve roster | | | Before |
| 4/14/2005 | VIP | Penny | Promoted to active roster | | | Before |
| 4/19/2005 | KAN | Aquino | Promoted to active roster | | | Before |
| 4/19/2005 | KAN | Floyd | Demoted to reserve roster | | | Before |
| 4/19/2005 | KAN | Franco | Promoted to active roster | | | Before |
| 4/19/2005 | KAN | Lamb | Promoted to active roster | | | Before |
| 4/19/2005 | KAN | Piazza | Demoted to reserve roster | | | Before |
| 4/19/2005 | KAN | Redman | Demoted to reserve roster | | | Before |
| 4/19/2005 | KAN | Redman | Promoted to active roster | | | Before |
| 4/19/2005 | KAN | Remlinger | Demoted to reserve roster | | | Before |
| 4/19/2005 | KAN | Sanchez | Demoted to reserve roster | | | Before |
| 4/19/2005 | KAN | Sanchez | Promoted to active roster | | | Before |
| 4/20/2005 | B C | Brocail | Promoted to active roster | | | Before |
| 4/20/2005 | B C | DuBose | Promoted to active roster | | | Before |
| 4/20/2005 | B C | Harper | Demoted to reserve roster | | | Before |
| 4/20/2005 | B C | Lowe | Demoted to reserve roster | | | Before |
| 4/20/2005 | B C | Osuna | Promoted to active roster | | | Before |
| 4/20/2005 | B C | Riske | Demoted to reserve roster | | | Before |
| 4/20/2005 | COM | Cota | Demoted to reserve roster | | | Before |
| 4/20/2005 | COM | Dreifort | Demoted to reserve roster | | | Before |
| 4/20/2005 | COM | Haren | Promoted to active roster | | | Before |
| 4/20/2005 | COM | Jones | Promoted to active roster | | | Before |
| 4/20/2005 | DRI | Holliday | Demoted to reserve roster | | | Before |
| 4/20/2005 | DRI | Mackowiak | Promoted to active roster | | | Before |
| 4/20/2005 | FOR | Bocachica | Signed | | | Before |
| 4/20/2005 | FOR | Cabrera | Promoted to active roster | | | Before |
| 4/20/2005 | FOR | Ohka | Demoted to reserve roster | | | Before |
| 4/20/2005 | FOR | Ohka | Promoted to active roster | | | Before |
| 4/20/2005 | FOR | Pettitte | Demoted to reserve roster | | | Before |
| 4/20/2005 | FOR | Sanchez | Released | | | Before |
| 4/20/2005 | FOR | Sweeney | Demoted to reserve roster | | | Before |
| 4/20/2005 | FOR | Telemaco | Promoted to active roster | | | Before |
| 4/20/2005 | FOR | Witasick | Demoted to reserve roster | | | Before |
| 4/20/2005 | HEN | Cust | Signed | | | Before |
| 4/20/2005 | HEN | Cust | Demoted to reserve roster | | | Before |
| 4/20/2005 | HEN | Pascucci | Released | | | Before |
| 4/20/2005 | HEN | Rhodes | Demoted to reserve roster | | | Before |
| 4/20/2005 | HEN | Williamson | Promoted to active roster | | | Before |
| 4/20/2005 | PIN | Dempster | Promoted to active roster | | | Before |
| 4/20/2005 | PIN | Everett | Demoted to reserve roster | | | Before |
| 4/20/2005 | PIN | Nixon | Promoted to active roster | | | Before |
| 4/20/2005 | PIN | Qualls | Demoted to reserve roster | | | Before |
| 4/20/2005 | SLG | Blanton | Demoted to reserve roster | | | Before |
| 4/20/2005 | SLG | Eischen | Promoted to active roster | | | Before |
| 4/20/2005 | SYN | Dominguez | Demoted to reserve roster | | | Before |
| 4/20/2005 | SYN | Dominguez | Promoted to active roster | | | Before |
| 4/20/2005 | SYN | German | Demoted to reserve roster | | | Before |
| 4/20/2005 | SYN | German | Promoted to active roster | | | Before |
| 4/20/2005 | SYN | Reyes | Promoted to active roster | | | Before |
| 4/20/2005 | SYN | Reyes | Demoted to reserve roster | | | Before |
| 4/20/2005 | SYN | Tsao | Demoted to reserve roster | | | Before |
| 4/20/2005 | SYN | Tsao | Promoted to active roster | | | Before |
| 4/25/2005 | HYS | Anderson | Promoted to active roster | | | Before |
| 4/25/2005 | HYS | Bedard | Promoted to active roster | | | Before |
| 4/25/2005 | HYS | Cedeno | Promoted to active roster | | | Before |
| 4/25/2005 | HYS | Choi | Demoted to reserve roster | | | Before |
| 4/25/2005 | HYS | Francis | Promoted to active roster | | | Before |
| 4/25/2005 | HYS | Grimsley | Promoted to active roster | | | Before |
| 4/25/2005 | HYS | Heilman | Demoted to reserve roster | | | Before |
| 4/25/2005 | HYS | Heilman | Promoted to active roster | | | Before |
| 4/25/2005 | HYS | Hill | Promoted to active roster | | | Before |
| 4/25/2005 | HYS | Infante | Demoted to reserve roster | | | Before |
| 4/25/2005 | HYS | Mecir | Demoted to reserve roster | | | Before |
| 4/25/2005 | HYS | Peavy | Demoted to reserve roster | | | Before |
| 4/25/2005 | HYS | Ross | Demoted to reserve roster | | | Before |
| 4/25/2005 | HYS | Wilson | Demoted to reserve roster | | | Before |
| 4/25/2005 | KAN | Lamb | Demoted to reserve roster | | | Before |
| 4/25/2005 | KAN | Piazza | Promoted to active roster | | | Before |
| 4/25/2005 | PIN | Dempster | Demoted to reserve roster | | | Before |
| 4/25/2005 | PIN | Everett | Promoted to active roster | | | Before |
| 4/25/2005 | PIN | Nixon | Demoted to reserve roster | | | Before |
| 4/25/2005 | PIN | Qualls | Promoted to active roster | | | Before |
| 4/25/2005 | SYN | Dominguez | Promoted to active roster | | | Before |
| 4/25/2005 | SYN | German | Promoted to active roster | | | Before |
| 4/25/2005 | SYN | Larkin | Demoted to reserve roster | | | Before |
| 4/25/2005 | SYN | Mauer | Demoted to reserve roster | | | Before |
| 4/25/2005 | SYN | Reyes | Demoted to reserve roster | | | Before |
| 4/25/2005 | SYN | Reyes | Promoted to active roster | | | Before |
| 4/25/2005 | SYN | Tsao | Demoted to reserve roster | | | Before |
| 4/25/2005 | SYN | Valentin | Promoted to active roster | | | Before |
| 4/27/2005 | B C | Lowe | Promoted to active roster | | | Before |
| 4/27/2005 | B C | Madritsch | Demoted to reserve roster | | | Before |
| 4/27/2005 | B C | Tadano | Promoted to active roster | | | Before |
| 4/27/2005 | B C | Washburn | Demoted to reserve roster | | | Before |
| 4/27/2005 | BAN | Bako | Signed | | | Before |
| 4/27/2005 | BAN | DeRosa | Signed | | | Before |
| 4/27/2005 | BAN | Quiroz | Demoted to reserve roster | | | Before |
| 4/27/2005 | BAN | Spiezio | Demoted to reserve roster | | | Before |
| 4/27/2005 | BAN | Spiezio | Promoted to active roster | | | Before |
| 4/27/2005 | BST | Guardado | Promoted to active roster | | | Before |
| 4/27/2005 | BST | Wood | Demoted to reserve roster | | | Before |
| 4/27/2005 | COM | Armas | Demoted to reserve roster | | | Before |
| 4/27/2005 | COM | Cota | Promoted to active roster | | | Before |
| 4/27/2005 | COM | DeJean | Demoted to reserve roster | | | Before |
| 4/27/2005 | COM | Dreifort | Promoted to active roster | | | Before |
| 4/27/2005 | COM | Fossum | Promoted to active roster | | | Before |
| 4/27/2005 | COM | Haren | Demoted to reserve roster | | | Before |
| 4/27/2005 | COM | Loaiza | Demoted to reserve roster | | | Before |
| 4/27/2005 | COM | Wolf | Promoted to active roster | | | Before |
| 4/27/2005 | FOR | Cerda | Demoted to reserve roster | | | Before |
| 4/27/2005 | FOR | Delgado | Demoted to reserve roster | | | Before |
| 4/27/2005 | FOR | Delgado | Promoted to active roster | | | Before |
| 4/27/2005 | FOR | Ohka | Promoted to active roster | | | Before |
| 4/27/2005 | FOR | Saarloos | Demoted to reserve roster | | | Before |
| 4/27/2005 | FOR | Witasick | Promoted to active roster | | | Before |
| 4/27/2005 | HEN | Davis | Promoted to active roster | | | Before |
| 4/27/2005 | HEN | Redmond | Demoted to reserve roster | | | Before |
| 4/27/2005 | HEN | Rhodes | Promoted to active roster | | | Before |
| 4/27/2005 | HEN | Sanchez | Demoted to reserve roster | | | Before |
| 4/27/2005 | HYS | Anderson | Demoted to reserve roster | | | Before |
| 4/27/2005 | HYS | Cedeno | Demoted to reserve roster | | | Before |
| 4/27/2005 | HYS | Choi | Promoted to active roster | | | Before |
| 4/27/2005 | HYS | Infante | Promoted to active roster | | | Before |
| 4/27/2005 | HYS | Miller | Demoted to reserve roster | | | Before |
| 4/27/2005 | HYS | Peavy | Promoted to active roster | | | Before |
| 4/27/2005 | HYS | Tankersley | Demoted to reserve roster | | | Before |
| 4/27/2005 | HYS | Wilson | Promoted to active roster | | | Before |
| 4/27/2005 | IRI | Brazelton | Demoted to reserve roster | | | Before |
| 4/27/2005 | IRI | Gobble | Promoted to active roster | | | Before |
| 4/27/2005 | KAN | Bell | Demoted to reserve roster | | | Before |
| 4/27/2005 | KAN | Borkowski | Promoted to active roster | | | Before |
| 4/27/2005 | KAN | Floyd | Promoted to active roster | | | Before |
| 4/27/2005 | KAN | Ginter | Demoted to reserve roster | | | Before |
| 4/27/2005 | KAN | Hollandsworth | Demoted to reserve roster | | | Before |
| 4/27/2005 | KAN | Lamb | Promoted to active roster | | | Before |
| 4/27/2005 | KAN | Mesa | Demoted to reserve roster | | | Before |
| 4/27/2005 | KAN | Miller | Promoted to active roster | | | Before |
| 4/27/2005 | KAN | Munro | Promoted to active roster | | | Before |
| 4/27/2005 | KAN | Sanchez | Demoted to reserve roster | | | Before |
| 4/27/2005 | PEA | Carroll | Promoted to active roster | | | Before |
| 4/27/2005 | PEA | Klesko | Demoted to reserve roster | | | Before |
| 4/27/2005 | SKT | Gonzalez,L | Demoted to reserve roster | | | Before |
| 4/27/2005 | SKT | Ligtenberg | Promoted to active roster | | | Before |
| 4/27/2005 | SKT | Mendoza | Demoted to reserve roster | | | Before |
| 4/27/2005 | SKT | Obermueller | Promoted to active roster | | | Before |
| 4/27/2005 | SKT | Payton | Demoted to reserve roster | | | Before |
| 4/27/2005 | SKT | Santos | Demoted to reserve roster | | | Before |
| 4/27/2005 | SKT | Taguchi | Promoted to active roster | | | Before |
| 4/27/2005 | SKT | Tucker | Promoted to active roster | | | Before |
| 4/27/2005 | SLG | Donnelly | Demoted to reserve roster | | | Before |
| 4/27/2005 | SLG | Wickman | Promoted to active roster | | | Before |
| 5/2/2005 | COM | Affeldt | Demoted to reserve roster | | | Before |
| 5/2/2005 | COM | Armas | Promoted to active roster | | | Before |
| 5/2/2005 | COM | DeJean | Promoted to active roster | | | Before |
| 5/2/2005 | COM | Elarton | Demoted to reserve roster | | | Before |
| 5/2/2005 | COM | Fossum | Demoted to reserve roster | | | Before |
| 5/2/2005 | COM | Loaiza | Promoted to active roster | | | Before |
| 5/2/2005 | HEN | Garcia,D | Promoted to active roster | | | Before |
| 5/2/2005 | HEN | Wright | Demoted to reserve roster | | | Before |
| 5/2/2005 | KAN | Aquino | Demoted to reserve roster | | | Before |
| 5/2/2005 | KAN | Borkowski | Demoted to reserve roster | | | Before |
| 5/2/2005 | KAN | Hernandez | Promoted to active roster | | | Before |
| 5/2/2005 | KAN | Hollandsworth | Promoted to active roster | | | Before |
| 5/2/2005 | KAN | Mercker | Demoted to reserve roster | | | Before |
| 5/2/2005 | KAN | Mercker | Promoted to active roster | | | Before |
| 5/2/2005 | KAN | Mercker | Demoted to reserve roster | | | Before |
| 5/2/2005 | KAN | Munro | Demoted to reserve roster | | | Before |
| 5/2/2005 | KAN | Offerman | Promoted to active roster | | | Before |
| 5/2/2005 | KAN | Remlinger | Promoted to active roster | | | Before |
| 5/3/2005 | B C | DaVanon | Demoted to reserve roster | | | Before |
| 5/3/2005 | B C | Gibbons | Promoted to active roster | | | Before |
| 5/3/2005 | BAN | Ensberg | Demoted to reserve roster | | | Before |
| 5/3/2005 | BAN | Ginter | Promoted to active roster | | | Before |
| 5/3/2005 | BAN | McLemore | Demoted to reserve roster | | | Before |
| 5/3/2005 | BST | Cotts | Promoted to active roster | | | Before |
| 5/3/2005 | BST | Hendrickson | Demoted to reserve roster | | | Before |
| 5/3/2005 | BST | Miller | Demoted to reserve roster | | | Before |
| 5/3/2005 | BST | Navarro | Promoted to active roster | | | Before |
| 5/3/2005 | DRI | Castilla | Demoted to reserve roster | | | Before |
| 5/3/2005 | DRI | Castillo | Demoted to reserve roster | | | Before |
| 5/3/2005 | DRI | Castillo | Promoted to active roster | | | Before |
| 5/3/2005 | DRI | Clark | Demoted to reserve roster | | | Before |
| 5/3/2005 | DRI | Green | Demoted to reserve roster | | | Before |
| 5/3/2005 | DRI | Green | Promoted to active roster | | | Before |
| 5/3/2005 | DRI | Larson | Promoted to active roster | | | Before |
| 5/3/2005 | DRI | Raines | Promoted to active roster | | | Before |
| 5/3/2005 | DRI | Sele | Demoted to reserve roster | | | Before |
| 5/3/2005 | DRI | Sturtze | Promoted to active roster | | | Before |
| 5/3/2005 | DRI | Stynes | Demoted to reserve roster | | | Before |
| 5/3/2005 | DRI | Valent | Promoted to active roster | | | Before |
| 5/3/2005 | FOR | Barmes | Demoted to reserve roster | | | Before |
| 5/3/2005 | FOR | Cerda | Promoted to active roster | | | Before |
| 5/3/2005 | FOR | Delgado | Promoted to active roster | | | Before |
| 5/3/2005 | FOR | Ohka | Demoted to reserve roster | | | Before |
| 5/3/2005 | FOR | Pettitte | Promoted to active roster | | | Before |
| 5/3/2005 | FOR | Telemaco | Demoted to reserve roster | | | Before |
| 5/3/2005 | HYS | Anderson | Promoted to active roster | | | Before |
| 5/3/2005 | HYS | Benoit | Demoted to reserve roster | | | Before |
| 5/3/2005 | HYS | Carrasco | Promoted to active roster | | | Before |
| 5/3/2005 | HYS | Choi | Demoted to reserve roster | | | Before |
| 5/3/2005 | HYS | Heilman | Promoted to active roster | | | Before |
| 5/3/2005 | HYS | Miller | Promoted to active roster | | | Before |
| 5/3/2005 | HYS | Molina,J | Demoted to reserve roster | | | Before |
| 5/3/2005 | HYS | Peavy | Demoted to reserve roster | | | Before |
| 5/3/2005 | HYS | Perez | Demoted to reserve roster | | | Before |
| 5/3/2005 | HYS | Perisho | Demoted to reserve roster | | | Before |
| 5/3/2005 | HYS | Ross | Promoted to active roster | | | Before |
| 5/3/2005 | HYS | Woodward | Promoted to active roster | | | Before |
| 5/3/2005 | IRI | Adams,R | Demoted to reserve roster | | | Before |
| 5/3/2005 | IRI | Gonzalez | Promoted to active roster | | | Before |
| 5/3/2005 | PIN | Everett | Demoted to reserve roster | | | Before |
| 5/3/2005 | PIN | McEwing | Promoted to active roster | | | Before |
| 5/3/2005 | PIN | Nixon | Promoted to active roster | | | Before |
| 5/3/2005 | PIN | Young | Demoted to reserve roster | | | Before |
| 5/3/2005 | SKT | Gonzalez | Demoted to reserve roster | | | Before |
| 5/3/2005 | SKT | Lima | Demoted to reserve roster | | | Before |
| 5/3/2005 | SKT | Majewski | Promoted to active roster | | | Before |
| 5/3/2005 | SKT | Seo | Promoted to active roster | | | Before |
| 5/3/2005 | SLG | Betemit | Promoted to active roster | | | Before |
| 5/3/2005 | SLG | Grudzielanek | Demoted to reserve roster | | | Before |
| 5/3/2005 | SLG | Kroeger | Promoted to active roster | | | Before |
| 5/3/2005 | SLG | Wickman | Demoted to reserve roster | | | Before |
| 5/8/2005 | FOR | Castillo | Demoted to reserve roster | | | Before |
| 5/8/2005 | FOR | Cerda | Demoted to reserve roster | | | Before |
| 5/8/2005 | FOR | Neal | Promoted to active roster | | | Before |
| 5/8/2005 | FOR | Ohka | Promoted to active roster | | | Before |
| 5/8/2005 | FOR | Pettitte | Demoted to reserve roster | | | Before |
| 5/8/2005 | FOR | Sweeney | Promoted to active roster | | | Before |
| 5/8/2005 | FOR | Telemaco | Promoted to active roster | | | Before |
| 5/8/2005 | FOR | Witasick | Demoted to reserve roster | | | Before |
| 5/10/2005 | B C | Bush | Demoted to reserve roster | | | Before |
| 5/10/2005 | B C | Camp | Promoted to active roster | | | Before |
| 5/10/2005 | B C | DuBose | Demoted to reserve roster | | | Before |
| 5/10/2005 | B C | Flaherty | Demoted to reserve roster | | | Before |
| 5/10/2005 | B C | Flaherty | Promoted to active roster | | | Before |
| 5/10/2005 | B C | Harper | Promoted to active roster | | | Before |
| 5/10/2005 | B C | Lowe | Demoted to reserve roster | | | Before |
| 5/10/2005 | B C | Madritsch | Promoted to active roster | | | Before |
| 5/10/2005 | B C | Mientkiewicz | Demoted to reserve roster | | | Before |
| 5/10/2005 | B C | Mientkiewicz | Promoted to active roster | | | Before |
| 5/10/2005 | B C | Podsednik | Demoted to reserve roster | | | Before |
| 5/10/2005 | B C | Reyes | Promoted to active roster | | | Before |
| 5/10/2005 | B C | Tadano | Demoted to reserve roster | | | Before |
| 5/10/2005 | B C | Washburn | Promoted to active roster | | | Before |
| 5/10/2005 | BLU | Hall | Demoted to reserve roster | | | Before |
| 5/10/2005 | BLU | Hall | Promoted to active roster | | | Before |
| 5/10/2005 | BLU | Hall | Promoted to active roster | | | Before |
| 5/10/2005 | BLU | Lopez,J | Demoted to reserve roster | | | Before |
| 5/10/2005 | BLU | Lopez,J | Promoted to active roster | | | Before |
| 5/10/2005 | BLU | Lopez,J | Demoted to reserve roster | | | Before |
| 5/10/2005 | BST | Jordan | Promoted to active roster | | | Before |
| 5/10/2005 | BST | Navarro | Demoted to reserve roster | | | Before |
| 5/10/2005 | COM | Affeldt | Promoted to active roster | | | Before |
| 5/10/2005 | COM | Armas | Demoted to reserve roster | | | Before |
| 5/10/2005 | COM | Elarton | Promoted to active roster | | | Before |
| 5/10/2005 | COM | Gryboski | Demoted to reserve roster | | | Before |
| 5/10/2005 | COM | Haren | Promoted to active roster | | | Before |
| 5/10/2005 | COM | Loaiza | Demoted to reserve roster | | | Before |
| 5/10/2005 | COM | Patterson | Promoted to active roster | | | Before |
| 5/10/2005 | COM | Wolf | Demoted to reserve roster | | | Before |
| 5/10/2005 | DRI | Larson | Demoted to reserve roster | | | Before |
| 5/10/2005 | DRI | Palmeiro | Promoted to active roster | | | Before |
| 5/10/2005 | DRI | Stairs | Demoted to reserve roster | | | Before |
| 5/10/2005 | DRI | Stynes | Promoted to active roster | | | Before |
| 5/10/2005 | FOR | Castillo | Released | | | Before |
| 5/10/2005 | FOR | Ojeda | Signed | | | Before |
| 5/10/2005 | HSX | Colome | Demoted to reserve roster | | | Before |
| 5/10/2005 | HSX | Liriano | Promoted to active roster | | | Before |
| 5/10/2005 | HYS | Benoit | Promoted to active roster | | | Before |
| 5/10/2005 | HYS | Carrasco | Demoted to reserve roster | | | Before |
| 5/10/2005 | HYS | Choi | Promoted to active roster | | | Before |
| 5/10/2005 | HYS | Francis | Demoted to reserve roster | | | Before |
| 5/10/2005 | HYS | Heilman | Demoted to reserve roster | | | Before |
| 5/10/2005 | HYS | Molina,J | Promoted to active roster | | | Before |
| 5/10/2005 | HYS | Peavy | Promoted to active roster | | | Before |
| 5/10/2005 | HYS | Perisho | Promoted to active roster | | | Before |
| 5/10/2005 | HYS | Ross | Demoted to reserve roster | | | Before |
| 5/10/2005 | HYS | Teixeira | Demoted to reserve roster | | | Before |
| 5/10/2005 | HYS | Teixeira | Promoted to active roster | | | Before |
| 5/10/2005 | HYS | Woodward | Demoted to reserve roster | | | Before |
| 5/10/2005 | KAN | Lamb | Demoted to reserve roster | | | Before |
| 5/10/2005 | KAN | Mercker | Promoted to active roster | | | Before |
| 5/10/2005 | KAN | Remlinger | Demoted to reserve roster | | | Before |
| 5/10/2005 | KAN | Sanchez | Promoted to active roster | | | Before |
| 5/10/2005 | PEA | Carroll | Demoted to reserve roster | | | Before |
| 5/10/2005 | PEA | Klesko | Promoted to active roster | | | Before |
| 5/10/2005 | PIN | Jacobsen | Demoted to reserve roster | | | Before |
| 5/10/2005 | PIN | Logan | Promoted to active roster | | | Before |
| 5/10/2005 | SKT | Gonzalez | Demoted to reserve roster | | | Before |
| 5/10/2005 | SKT | Gonzalez,L | Demoted to reserve roster | | | Before |
| 5/10/2005 | SKT | Gonzalez,L | Promoted to active roster | | | Before |
| 5/10/2005 | SKT | Kata | Demoted to reserve roster | | | Before |
| 5/10/2005 | SKT | Kata | Promoted to active roster | | | Before |
| 5/10/2005 | SKT | Kata | Promoted to active roster | | | Before |
| 5/10/2005 | SKT | Olerud | Demoted to reserve roster | | | Before |
| 5/10/2005 | SKT | Payton | Promoted to active roster | | | Before |
| 5/10/2005 | SKT | Radke | Demoted to reserve roster | | | Before |
| 5/10/2005 | SKT | Santos | Promoted to active roster | | | Before |
| 5/10/2005 | SKT | Taguchi | Demoted to reserve roster | | | Before |
| 5/10/2005 | SKT | Zeile | Promoted to active roster | | | Before |
| 5/10/2005 | SLG | Betemit | Demoted to reserve roster | | | Before |
| 5/10/2005 | SLG | Grudzielanek | Promoted to active roster | | | Before |
| 5/15/2005 | KAN | Bell | Promoted to active roster | | | Before |
| 5/15/2005 | KAN | Lamb | Promoted to active roster | | | Before |
| 5/15/2005 | KAN | Miller | Demoted to reserve roster | | | Before |
| 5/15/2005 | KAN | Sanchez | Demoted to reserve roster | | | Before |
| 5/15/2005 | PIN | Catalanotto | Promoted to active roster | | | Before |
| 5/15/2005 | PIN | Everett | Promoted to active roster | | | Before |
| 5/15/2005 | PIN | Hafner | Demoted to reserve roster | | | Before |
| 5/15/2005 | PIN | Jacobsen | Promoted to active roster | | | Before |
| 5/15/2005 | PIN | Logan | Demoted to reserve roster | | | Before |
| 5/15/2005 | PIN | Looper | Promoted to active roster | | | Before |
| 5/15/2005 | PIN | Nixon | Demoted to reserve roster | | | Before |
| 5/15/2005 | PIN | Percival | Demoted to reserve roster | | | Before |
| 5/15/2005 | PIN | Youkilis | Demoted to reserve roster | | | Before |
| 5/15/2005 | PIN | Young | Promoted to active roster | | | Before |
| 5/16/2005 | B C | Bush | Promoted to active roster | | | Before |
| 5/16/2005 | B C | Camp | Demoted to reserve roster | | | Before |
| 5/16/2005 | B C | Flaherty | Promoted to active roster | | | Before |
| 5/16/2005 | B C | Harvey | Demoted to reserve roster | | | Before |
| 5/16/2005 | B C | Lowe | Promoted to active roster | | | Before |
| 5/16/2005 | B C | Madritsch | Demoted to reserve roster | | | Before |
| 5/16/2005 | B C | Riske | Promoted to active roster | | | Before |
| 5/16/2005 | B C | Washburn | Demoted to reserve roster | | | Before |
| 5/16/2005 | BOU | Ainsworth | Promoted to active roster | | | Before |
| 5/16/2005 | BOU | Rauch | Demoted to reserve roster | | | Before |
| 5/16/2005 | COM | Affeldt | Demoted to reserve roster | | | Before |
| 5/16/2005 | COM | DeJean | Demoted to reserve roster | | | Before |
| 5/16/2005 | COM | Fossum | Promoted to active roster | | | Before |
| 5/16/2005 | COM | Gryboski | Promoted to active roster | | | Before |
| 5/16/2005 | FOR | Cerda | Promoted to active roster | | | Before |
| 5/16/2005 | FOR | Neal | Demoted to reserve roster | | | Before |
| 5/16/2005 | PEA | Halladay | Demoted to reserve roster | | | Before |
| 5/16/2005 | PEA | Lieber | Promoted to active roster | | | Before |
| 5/16/2005 | PHO | Cantu | Demoted to reserve roster | | | Before |
| 5/16/2005 | PHO | Upton | Promoted to active roster | | | Before |
| 5/16/2005 | SCO | Chen | Promoted to active roster | | | Before |
| 5/16/2005 | SCO | Lopez,R | Demoted to reserve roster | | | Before |
| 5/16/2005 | SKT | Gonzalez,L | Promoted to active roster | | | Before |
| 5/16/2005 | SKT | Higginson | Demoted to reserve roster | | | Before |
| 5/16/2005 | SKT | Lima | Promoted to active roster | | | Before |
| 5/16/2005 | SKT | Majewski | Demoted to reserve roster | | | Before |
| 5/16/2005 | SKT | Mendoza | Promoted to active roster | | | Before |
| 5/16/2005 | SKT | Radke | Promoted to active roster | | | Before |
| 5/16/2005 | SKT | Seo | Demoted to reserve roster | | | Before |
| 5/16/2005 | SKT | Sierra | Demoted to reserve roster | | | Before |
| 5/16/2005 | SKT | Sierra | Promoted to active roster | | | Before |
| 5/16/2005 | SKT | Trachsel | Demoted to reserve roster | | | Before |
| 5/16/2005 | SLG | Donnelly | Promoted to active roster | | | Before |
| 5/16/2005 | SLG | Eischen | Demoted to reserve roster | | | Before |
| 5/16/2005 | SLG | Hancock | Demoted to reserve roster | | | Before |
| 5/16/2005 | SLG | Hunter | Demoted to reserve roster | | | Before |
| 5/16/2005 | SLG | Prior | Promoted to active roster | | | Before |
| 5/16/2005 | SLG | Restovich | Promoted to active roster | | | Before |
| 5/16/2005 | SYN | Hairston | Demoted to reserve roster | | | Before |
| 5/16/2005 | SYN | Larkin | Promoted to active roster | | | Before |
| 5/21/2005 | BLU | Ayala | Promoted to active roster | | | Before |
| 5/21/2005 | BLU | Farnsworth | Demoted to reserve roster | | | Before |
| 5/21/2005 | HYS | Cedeno | Promoted to active roster | | | Before |
| 5/21/2005 | HYS | Greene | Demoted to reserve roster | | | Before |
| 5/21/2005 | HYS | Lopez | Demoted to reserve roster | | | Before |
| 5/21/2005 | HYS | Mecir | Promoted to active roster | | | Before |
| 5/21/2005 | HYS | Miller | Demoted to reserve roster | | | Before |
| 5/21/2005 | HYS | Perez | Promoted to active roster | | | Before |
| 5/21/2005 | HYS | Ross | Promoted to active roster | | | Before |
| 5/21/2005 | HYS | White | Demoted to reserve roster | | | Before |
| 5/23/2005 | B C | Bush | Demoted to reserve roster | | | Before |
| 5/23/2005 | B C | DuBose | Promoted to active roster | | | Before |
| 5/23/2005 | B C | Lowe | Demoted to reserve roster | | | Before |
| 5/23/2005 | B C | Madritsch | Promoted to active roster | | | Before |
| 5/23/2005 | B C | Ramirez | Promoted to active roster | | | Before |
| 5/23/2005 | B C | Washburn | Promoted to active roster | | | Before |
| 5/23/2005 | BAN | Blum | Promoted to active roster | | | Before |
| 5/23/2005 | BAN | Ensberg | Promoted to active roster | | | Before |
| 5/23/2005 | BAN | Gil | Demoted to reserve roster | | | Before |
| 5/23/2005 | BAN | McLemore | Promoted to active roster | | | Before |
| 5/23/2005 | BAN | Nageotte | Demoted to reserve roster | | | Before |
| 5/23/2005 | BAN | Van Benschoten | Demoted to reserve roster | | | Before |
| 5/23/2005 | BOU | Garcia | Promoted to active roster | | | Before |
| 5/23/2005 | BOU | Rodriguez | Demoted to reserve roster | | | Before |
| 5/23/2005 | COM | Affeldt | Promoted to active roster | | | Before |
| 5/23/2005 | COM | Armas | Promoted to active roster | | | Before |
| 5/23/2005 | COM | DeJean | Promoted to active roster | | | Before |
| 5/23/2005 | COM | Elarton | Demoted to reserve roster | | | Before |
| 5/23/2005 | COM | Fossum | Demoted to reserve roster | | | Before |
| 5/23/2005 | COM | Gryboski | Demoted to reserve roster | | | Before |
| 5/23/2005 | COM | Haren | Demoted to reserve roster | | | Before |
| 5/23/2005 | COM | Loaiza | Promoted to active roster | | | Before |
| 5/23/2005 | COM | Patterson | Demoted to reserve roster | | | Before |
| 5/23/2005 | COM | Wolf | Promoted to active roster | | | Before |
| 5/23/2005 | DRI | Castillo | Promoted to active roster | | | Before |
| 5/23/2005 | DRI | Fassero | Promoted to active roster | | | Before |
| 5/23/2005 | DRI | Levine | Demoted to reserve roster | | | Before |
| 5/23/2005 | DRI | Stairs | Promoted to active roster | | | Before |
| 5/23/2005 | DRI | Sturtze | Demoted to reserve roster | | | Before |
| 5/23/2005 | DRI | Stynes | Demoted to reserve roster | | | Before |
| 5/23/2005 | FOR | Knotts | Released | | | Before |
| 5/23/2005 | FOR | Laker | Signed | | | Before |
| 5/23/2005 | FOR | McPherson | Demoted to reserve roster | | | Before |
| 5/23/2005 | FOR | Neal | Promoted to active roster | | | Before |
| 5/23/2005 | FOR | Ohka | Demoted to reserve roster | | | Before |
| 5/23/2005 | FOR | Pettitte | Promoted to active roster | | | Before |
| 5/23/2005 | FOR | Ransom | Signed | | | Before |
| 5/23/2005 | FOR | Rincon | Demoted to reserve roster | | | Before |
| 5/23/2005 | FOR | Sweeney | Demoted to reserve roster | | | Before |
| 5/23/2005 | FOR | Sweeney | Promoted to active roster | | | Before |
| 5/23/2005 | FOR | Telemaco | Released | | | Before |
| 5/23/2005 | FOR | Walker | Demoted to reserve roster | | | Before |
| 5/23/2005 | FOR | Witasick | Promoted to active roster | | | Before |
| 5/23/2005 | HSX | Capellan | Promoted to active roster | | | Before |
| 5/23/2005 | HSX | Kline | Demoted to reserve roster | | | Before |
| 5/23/2005 | IRI | Choate | Promoted to active roster | | | Before |
| 5/23/2005 | IRI | Gobble | Demoted to reserve roster | | | Before |
| 5/23/2005 | IRI | Kazmir | Promoted to active roster | | | Before |
| 5/23/2005 | IRI | Seay | Demoted to reserve roster | | | Before |
| 5/23/2005 | IRI | Valverde | Promoted to active roster | | | Before |
| 5/23/2005 | IRI | Wuertz | Demoted to reserve roster | | | Before |
| 5/23/2005 | KAN | Aquino | Promoted to active roster | | | Before |
| 5/23/2005 | KAN | Betancourt | Demoted to reserve roster | | | Before |
| 5/23/2005 | KAN | Floyd | Demoted to reserve roster | | | Before |
| 5/23/2005 | KAN | Floyd | Promoted to active roster | | | Before |
| 5/23/2005 | KAN | Munro | Promoted to active roster | | | Before |
| 5/23/2005 | KAN | Surhoff | Demoted to reserve roster | | | Before |
| 5/23/2005 | PEA | Benson | Demoted to reserve roster | | | Before |
| 5/23/2005 | PEA | Burnett | Promoted to active roster | | | Before |
| 5/23/2005 | PEA | Carroll | Promoted to active roster | | | Before |
| 5/23/2005 | PEA | Erstad | Demoted to reserve roster | | | Before |
| 5/23/2005 | PEA | Freeman | Promoted to active roster | | | Before |
| 5/23/2005 | PEA | Klesko | Demoted to reserve roster | | | Before |
| 5/23/2005 | PEA | Morneau | Promoted to active roster | | | Before |
| 5/23/2005 | PEA | Uribe | Demoted to reserve roster | | | Before |
| 5/23/2005 | PIN | Everett | Demoted to reserve roster | | | Before |
| 5/23/2005 | PIN | Hafner | Promoted to active roster | | | Before |
| 5/23/2005 | PIN | Percival | Promoted to active roster | | | Before |
| 5/23/2005 | PIN | Qualls | Demoted to reserve roster | | | Before |
| 5/23/2005 | PIN | Youkilis | Promoted to active roster | | | Before |
| 5/23/2005 | PIN | Young | Demoted to reserve roster | | | Before |
| 5/23/2005 | SKT | Gonzalez | Promoted to active roster | | | Before |
| 5/23/2005 | SKT | Gonzalez | Promoted to active roster | | | Before |
| 5/23/2005 | SKT | Lima | Demoted to reserve roster | | | Before |
| 5/23/2005 | SKT | Mendoza | Demoted to reserve roster | | | Before |
| 5/23/2005 | SKT | Sierra | Demoted to reserve roster | | | Before |
| 5/23/2005 | SKT | Trachsel | Promoted to active roster | | | Before |
| 5/23/2005 | SLG | Griffey | Promoted to active roster | | | Before |
| 5/23/2005 | SLG | Hunter | Promoted to active roster | | | Before |
| 5/23/2005 | SLG | Kroeger | Demoted to reserve roster | | | Before |
| 5/23/2005 | SLG | Restovich | Demoted to reserve roster | | | Before |
| 5/23/2005 | SYN | Hairston | Promoted to active roster | | | Before |
| 5/23/2005 | SYN | Reyes | Demoted to reserve roster | | | Before |
| 5/28/2005 | B C | DaVanon | Promoted to active roster | | | Before |
| 5/28/2005 | B C | DuBose | Demoted to reserve roster | | | Before |
| 5/28/2005 | B C | Gibbons | Demoted to reserve roster | | | Before |
| 5/28/2005 | B C | Osuna | Demoted to reserve roster | | | Before |
| 5/28/2005 | FOR | Wright | Acquired via trade | PHO | | After |
| 5/28/2005 | HEN | Hawkins | Traded away | SCO | | After |
| 5/28/2005 | HEN | Hawkins | Acquired via trade | SCO | | After |
| 5/28/2005 | HEN | Hawkins | Acquired via trade | SCO | | After |
| 5/28/2005 | PHO | Wright | Traded away | FOR | | After |
| 5/28/2005 | PIN | Everett | Promoted to active roster | | | Before |
| 5/28/2005 | PIN | Hatteberg | Demoted to reserve roster | | | Before |
| 5/28/2005 | PIN | Logan | Demoted to reserve roster | | | Before |
| 5/28/2005 | PIN | Logan | Promoted to active roster | | | Before |
| 5/28/2005 | PIN | Youkilis | Demoted to reserve roster | | | Before |
| 5/28/2005 | PIN | Young | Promoted to active roster | | | Before |
| 5/28/2005 | SCO | Hawkins | Traded away | HEN | | After |
| 5/28/2005 | SCO | Hawkins | Traded away | HEN | | After |
| 5/28/2005 | SCO | Hawkins | Acquired via trade | HEN | | After |
| 5/29/2005 | B C | Camp | Promoted to active roster | | | Before |
| 5/29/2005 | B C | DaVanon | Demoted to reserve roster | | | Before |
| 5/29/2005 | B C | Harper | Demoted to reserve roster | | | Before |
| 5/29/2005 | B C | Harvey | Promoted to active roster | | | Before |
| 5/29/2005 | B C | Madritsch | Demoted to reserve roster | | | Before |
| 5/29/2005 | B C | Martinez | Demoted to reserve roster | | | Before |
| 5/29/2005 | B C | Mientkiewicz | Promoted to active roster | | | Before |
| 5/29/2005 | B C | Podsednik | Promoted to active roster | | | Before |
| 5/29/2005 | B C | Ramirez | Demoted to reserve roster | | | Before |
| 5/29/2005 | B C | Tadano | Promoted to active roster | | | Before |
| 5/29/2005 | BAN | Guiel | Demoted to reserve roster | | | Before |
| 5/29/2005 | BAN | Guzman | Promoted to active roster | | | Before |
| 5/29/2005 | BAN | Krynzel | Demoted to reserve roster | | | Before |
| 5/29/2005 | BLU | Floyd | Promoted to active roster | | | Before |
| 5/29/2005 | BLU | Valdez | Demoted to reserve roster | | | Before |
| 5/29/2005 |