| Transactions |
| Date | Team | Player | Type | OthTm | EffDate | When |
| 3/31/2007 | DRI | Gonzalez | Traded away | HEG | | After |
| 3/31/2007 | DRI | Miller | Acquired via trade | BOU | | After |
| 3/31/2007 | DRI | Pedroia | Acquired via trade | HEG | | After |
| 3/31/2007 | DRI | Ryan | Acquired via trade | BOU | | After |
| 3/31/2007 | DRI | Stairs | Traded away | HEG | | After |
| 3/31/2007 | DRI | Weaver | Traded away | BOU | | After |
| 4/4/2008 | VIC | Duncan | Promoted to active roster | | | Before |
| 4/5/2008 | SCO | Hairston | Promoted to active roster | | | Before |
| 4/5/2008 | VIC | Votto | Promoted to active roster | | | Before |
| 4/6/2008 | B C | Bergmann | Promoted to active roster | | | Before |
| 4/6/2008 | B C | Burgos | Demoted to reserve roster | | | Before |
| 4/6/2008 | B C | Dellucci | Promoted to active roster | | | Before |
| 4/6/2008 | B C | Garza | Demoted to reserve roster | | | Before |
| 4/6/2008 | B C | Kuo | Promoted to active roster | | | Before |
| 4/6/2008 | B C | Loewen | Promoted to active roster | | | Before |
| 4/6/2008 | B C | Mitre | Demoted to reserve roster | | | Before |
| 4/6/2008 | B C | Salazar | Demoted to reserve roster | | | Before |
| 4/6/2008 | DRI | Barton | Promoted to active roster | | | Before |
| 4/6/2008 | DRI | Bonifacio | Demoted to reserve roster | | | Before |
| 4/6/2008 | DRI | Bonifacio | Promoted to active roster | | | Before |
| 4/6/2008 | DRI | Guzman | Promoted to active roster | | | Before |
| 4/6/2008 | DRI | Miller | Demoted to reserve roster | | | Before |
| 4/6/2008 | DRI | Ryan | Demoted to reserve roster | | | Before |
| 4/6/2008 | DRI | Wood | Demoted to reserve roster | | | Before |
| 4/6/2008 | DRI | Wood | Promoted to active roster | | | Before |
| 4/6/2008 | PIN | Cairo | Demoted to reserve roster | | | Before |
| 4/6/2008 | PIN | Hernandez,O | Promoted to active roster | | | Before |
| 4/6/2008 | PIN | Logan | Promoted to active roster | | | Before |
| 4/6/2008 | PIN | Looper | Demoted to reserve roster | | | Before |
| 4/6/2008 | SCO | Pena | Demoted to reserve roster | | | Before |
| 4/6/2008 | SKT | Aurilia | Promoted to active roster | | | Before |
| 4/6/2008 | SKT | Giles,M | Demoted to reserve roster | | | Before |
| 4/6/2008 | SKT | Gload | Demoted to reserve roster | | | Before |
| 4/6/2008 | SKT | Moseley | Promoted to active roster | | | Before |
| 4/6/2008 | VIC | Votto | Demoted to reserve roster | | | Before |
| 4/6/2008 | VIC | Wise | Demoted to reserve roster | | | Before |
| 4/7/2008 | PHO | Crisp | Promoted to active roster | | | Before |
| 4/8/2008 | SID | Callaspo | Promoted to active roster | | | Before |
| 4/10/2008 | PIN | Looper | Promoted to active roster | | | Before |
| 4/10/2008 | PIN | Sheets | Demoted to reserve roster | | | Before |
| 4/11/2008 | B C | Brown | Promoted to active roster | | | Before |
| 4/11/2008 | B C | Dellucci | Demoted to reserve roster | | | Before |
| 4/11/2008 | B C | Floyd | Promoted to active roster | | | Before |
| 4/11/2008 | B C | Garza | Demoted to reserve roster | | | Before |
| 4/11/2008 | B C | Garza | Promoted to active roster | | | Before |
| 4/11/2008 | B C | Kuo | Demoted to reserve roster | | | Before |
| 4/11/2008 | B C | Loewen | Demoted to reserve roster | | | Before |
| 4/11/2008 | B C | Mitre | Promoted to active roster | | | Before |
| 4/11/2008 | B C | Monroe | Demoted to reserve roster | | | Before |
| 4/11/2008 | B C | Richar | Promoted to active roster | | | Before |
| 4/11/2008 | B C | Sweeney | Promoted to active roster | | | Before |
| 4/11/2008 | B C | Tracy | Demoted to reserve roster | | | Before |
| 4/11/2008 | B C | VandenHurk | Promoted to active roster | | | Before |
| 4/11/2008 | B C | Volquez | Demoted to reserve roster | | | Before |
| 4/11/2008 | DRI | Barton | Demoted to reserve roster | | | Before |
| 4/11/2008 | DRI | Johnson | Promoted to active roster | | | Before |
| 4/11/2008 | DRI | Lincecum | Demoted to reserve roster | | | Before |
| 4/11/2008 | DRI | Prior | Demoted to reserve roster | | | Before |
| 4/11/2008 | DRI | Prior | Promoted to active roster | | | Before |
| 4/11/2008 | DRI | Wood | Promoted to active roster | | | Before |
| 4/11/2008 | PEA | Frandsen | Demoted to reserve roster | | | Before |
| 4/11/2008 | PEA | Ojeda | Promoted to active roster | | | Before |
| 4/11/2008 | PHO | Cruz | Demoted to reserve roster | | | Before |
| 4/11/2008 | PHO | Gallardo | Demoted to reserve roster | | | Before |
| 4/11/2008 | PHO | Huff | Promoted to active roster | | | Before |
| 4/11/2008 | PHO | Keppinger | Demoted to reserve roster | | | Before |
| 4/11/2008 | PHO | Ludwick | Demoted to reserve roster | | | Before |
| 4/11/2008 | PHO | Ludwick | Promoted to active roster | | | Before |
| 4/11/2008 | PHO | Springer | Demoted to reserve roster | | | Before |
| 4/11/2008 | PHO | Springer | Promoted to active roster | | | Before |
| 4/11/2008 | PHO | Vargas | Promoted to active roster | | | Before |
| 4/11/2008 | PHO | Ward | Demoted to reserve roster | | | Before |
| 4/11/2008 | PHO | Wassermann | Promoted to active roster | | | Before |
| 4/11/2008 | PIN | Castro | Promoted to active roster | | | Before |
| 4/11/2008 | SCO | Hairston | Demoted to reserve roster | | | Before |
| 4/11/2008 | SCO | Pena | Promoted to active roster | | | Before |
| 4/11/2008 | SID | Callaspo | Demoted to reserve roster | | | Before |
| 4/13/2008 | PIN | Castro | Demoted to reserve roster | | | Before |
| 4/17/2008 | B C | Bergmann | Demoted to reserve roster | | | Before |
| 4/17/2008 | B C | Brown | Demoted to reserve roster | | | Before |
| 4/17/2008 | B C | Dellucci | Promoted to active roster | | | Before |
| 4/17/2008 | B C | Garza | Promoted to active roster | | | Before |
| 4/17/2008 | B C | Johnson | Demoted to reserve roster | | | Before |
| 4/17/2008 | B C | Monroe | Promoted to active roster | | | Before |
| 4/17/2008 | DRI | Johnson | Demoted to reserve roster | | | Before |
| 4/17/2008 | DRI | Miller | Promoted to active roster | | | Before |
| 4/17/2008 | MAI | Albaladejo | Promoted to active roster | | | Before |
| 4/17/2008 | MAI | Alfonzo | Promoted to active roster | | | Before |
| 4/17/2008 | MAI | Bynum | Demoted to reserve roster | | | Before |
| 4/17/2008 | MAI | Duke | Promoted to active roster | | | Before |
| 4/17/2008 | MAI | Saunders | Demoted to reserve roster | | | Before |
| 4/17/2008 | MAI | Wilson | Demoted to reserve roster | | | Before |
| 4/17/2008 | PEA | Frandsen | Demoted to reserve roster | | | Before |
| 4/17/2008 | PEA | Ojeda | Promoted to active roster | | | Before |
| 4/17/2008 | PHO | Cruz | Promoted to active roster | | | Before |
| 4/17/2008 | PHO | Gallardo | Promoted to active roster | | | Before |
| 4/17/2008 | PHO | Huff | Demoted to reserve roster | | | Before |
| 4/17/2008 | PHO | Keppinger | Promoted to active roster | | | Before |
| 4/17/2008 | PHO | Vargas | Demoted to reserve roster | | | Before |
| 4/17/2008 | PHO | Wassermann | Demoted to reserve roster | | | Before |
| 4/18/2008 | SCO | Betancourt | Placed on disabled list | | 4/19/2008 | Before |
| 4/18/2008 | SCO | Hairston | Promoted to active roster | | | Before |
| 4/19/2008 | B C | Brown | Promoted to active roster | | | Before |
| 4/19/2008 | MAI | Bynum | Promoted to active roster | | | Before |
| 4/19/2008 | SKT | Gload | Promoted to active roster | | | Before |
| 4/20/2008 | SKT | Davis | Promoted to active roster | | | Before |
| 4/22/2008 | B C | Bergmann | Promoted to active roster | | | Before |
| 4/22/2008 | B C | Dellucci | Demoted to reserve roster | | | Before |
| 4/22/2008 | B C | Garza | Demoted to reserve roster | | | Before |
| 4/22/2008 | B C | Johnson | Promoted to active roster | | | Before |
| 4/22/2008 | B C | Richar | Demoted to reserve roster | | | Before |
| 4/22/2008 | B C | Salazar | Promoted to active roster | | | Before |
| 4/22/2008 | B C | Sweeney | Demoted to reserve roster | | | Before |
| 4/22/2008 | B C | Tracy | Promoted to active roster | | | Before |
| 4/22/2008 | MAI | Albaladejo | Demoted to reserve roster | | | Before |
| 4/22/2008 | MAI | Duke | Demoted to reserve roster | | | Before |
| 4/22/2008 | MAI | Saunders | Promoted to active roster | | | Before |
| 4/22/2008 | PHO | Cruz | Demoted to reserve roster | | | Before |
| 4/22/2008 | PHO | Gallardo | Demoted to reserve roster | | | Before |
| 4/22/2008 | PHO | Huff | Promoted to active roster | | | Before |
| 4/22/2008 | PHO | Ludwick | Demoted to reserve roster | | | Before |
| 4/22/2008 | PHO | Vargas | Promoted to active roster | | | Before |
| 4/22/2008 | PHO | Wassermann | Promoted to active roster | | | Before |
| 4/22/2008 | PIN | Castro | Promoted to active roster | | | Before |
| 4/22/2008 | PIN | Feierabend | Promoted to active roster | | | Before |
| 4/22/2008 | PIN | Hawkins | Demoted to reserve roster | | | Before |
| 4/22/2008 | PIN | Hernandez,O | Demoted to reserve roster | | | Before |
| 4/22/2008 | PIN | Rogers | Demoted to reserve roster | | | Before |
| 4/22/2008 | PIN | Rogers | Promoted to active roster | | | Before |
| 4/22/2008 | PIN | Sheets | Promoted to active roster | | | Before |
| 4/22/2008 | PIN | Thatcher | Demoted to reserve roster | | | Before |
| 4/22/2008 | PIN | Thatcher | Promoted to active roster | | | Before |
| 4/22/2008 | PIN | Varitek | Demoted to reserve roster | | | Before |
| 4/22/2008 | SCO | Betancourt | Activated from disabled list | | | Before |
| 4/22/2008 | SCO | Casilla | Promoted to active roster | | | Before |
| 4/22/2008 | SCO | Hairston | Demoted to reserve roster | | | Before |
| 4/22/2008 | SCO | Marte | Demoted to reserve roster | | | Before |
| 4/22/2008 | SKT | Buchholz | Promoted to active roster | | | Before |
| 4/22/2008 | SKT | Davis | Demoted to reserve roster | | | Before |
| 4/22/2008 | SKT | Gload | Demoted to reserve roster | | | Before |
| 4/22/2008 | SKT | Gonzalez | Promoted to active roster | | | Before |
| 4/22/2008 | SKT | O'Flaherty | Demoted to reserve roster | | | Before |
| 4/22/2008 | SKT | Trachsel | Demoted to reserve roster | | | Before |
| 4/23/2008 | SID | Callaspo | Promoted to active roster | | | Before |
| 4/24/2008 | PHO | Cruz | Promoted to active roster | | | Before |
| 4/24/2008 | SSX | Gomez | Promoted to active roster | | | Before |
| 4/25/2008 | PIN | Cairo | Promoted to active roster | | | Before |
| 4/26/2008 | PIN | Cairo | Demoted to reserve roster | | | Before |
| 4/26/2008 | PIN | Castro | Demoted to reserve roster | | | Before |
| 4/26/2008 | PIN | Feierabend | Demoted to reserve roster | | | Before |
| 4/26/2008 | PIN | Hawkins | Promoted to active roster | | | Before |
| 4/26/2008 | PIN | Hernandez,O | Promoted to active roster | | | Before |
| 4/26/2008 | PIN | Looper | Demoted to reserve roster | | | Before |
| 4/26/2008 | PIN | Varitek | Promoted to active roster | | | Before |
| 4/27/2008 | B C | Burgos | Promoted to active roster | | | Before |
| 4/27/2008 | B C | Dellucci | Demoted to reserve roster | | | Before |
| 4/27/2008 | B C | Dellucci | Promoted to active roster | | | Before |
| 4/27/2008 | B C | Kuo | Promoted to active roster | | | Before |
| 4/27/2008 | B C | Misch | Demoted to reserve roster | | | Before |
| 4/27/2008 | B C | Murphy | Demoted to reserve roster | | | Before |
| 4/27/2008 | B C | Peralta | Demoted to reserve roster | | | Before |
| 4/27/2008 | B C | Richar | Promoted to active roster | | | Before |
| 4/27/2008 | B C | Salazar | Demoted to reserve roster | | | Before |
| 4/27/2008 | PHO | Crisp | Demoted to reserve roster | | | Before |
| 4/27/2008 | PHO | Gallardo | Promoted to active roster | | | Before |
| 4/27/2008 | PHO | Huff | Demoted to reserve roster | | | Before |
| 4/27/2008 | PHO | Ludwick | Promoted to active roster | | | Before |
| 4/27/2008 | PHO | Vargas | Demoted to reserve roster | | | Before |
| 4/27/2008 | PHO | Ward | Promoted to active roster | | | Before |
| 4/27/2008 | PHO | Wassermann | Demoted to reserve roster | | | Before |
| 4/27/2008 | SCO | Hairston | Promoted to active roster | | | Before |
| 4/27/2008 | SCO | Pena | Demoted to reserve roster | | | Before |
| 4/27/2008 | SID | Callaspo | Demoted to reserve roster | | | Before |
| 4/27/2008 | SKT | Easley | Demoted to reserve roster | | | Before |
| 4/27/2008 | SKT | Gload | Promoted to active roster | | | Before |
| 4/27/2008 | SKT | Sampson | Demoted to reserve roster | | | Before |
| 4/27/2008 | SKT | Towers | Promoted to active roster | | | Before |
| 4/27/2008 | SSX | Gomez | Demoted to reserve roster | | | Before |
| 4/27/2008 | SSX | Humber | Promoted to active roster | | | Before |
| 4/27/2008 | SSX | Nolasco | Demoted to reserve roster | | | Before |
| 4/28/2008 | SID | Callaspo | Promoted to active roster | | | Before |
| 4/28/2008 | VIC | Anderson | Promoted to active roster | | | Before |
| 4/28/2008 | VIC | Peralta | Placed on disabled list | | 4/29/2008 | Before |
| 4/29/2008 | SCO | Bourn | Promoted to active roster | | | Before |
| 5/2/2008 | VIC | Peralta | Activated from disabled list | | | Before |
| 5/3/2008 | B C | Bergmann | Demoted to reserve roster | | | Before |
| 5/3/2008 | B C | Dellucci | Promoted to active roster | | | Before |
| 5/3/2008 | B C | Dukes | Demoted to reserve roster | | | Before |
| 5/3/2008 | B C | Garza | Promoted to active roster | | | Before |
| 5/3/2008 | DRI | Guzman | Demoted to reserve roster | | | Before |
| 5/3/2008 | DRI | Jurrjens | Promoted to active roster | | | Before |
| 5/3/2008 | DRI | Lincecum | Promoted to active roster | | | Before |
| 5/3/2008 | DRI | Paulino | Demoted to reserve roster | | | Before |
| 5/3/2008 | PEA | Frandsen | Demoted to reserve roster | | | Before |
| 5/3/2008 | PEA | Frandsen | Promoted to active roster | | | Before |
| 5/3/2008 | PEA | Grudzielanek | Demoted to reserve roster | | | Before |
| 5/3/2008 | PEA | Grudzielanek | Promoted to active roster | | | Before |
| 5/3/2008 | PHO | Crisp | Promoted to active roster | | | Before |
| 5/3/2008 | PHO | Huff | Promoted to active roster | | | Before |
| 5/3/2008 | PHO | Ludwick | Demoted to reserve roster | | | Before |
| 5/3/2008 | PHO | Ward | Demoted to reserve roster | | | Before |
| 5/3/2008 | SCO | Bourn | Demoted to reserve roster | | | Before |
| 5/3/2008 | SCO | Hairston | Demoted to reserve roster | | | Before |
| 5/3/2008 | SCO | Pena | Promoted to active roster | | | Before |
| 5/3/2008 | SID | Callaspo | Demoted to reserve roster | | | Before |
| 5/3/2008 | SKT | Buchholz | Demoted to reserve roster | | | Before |
| 5/3/2008 | SKT | Damon | Demoted to reserve roster | | | Before |
| 5/3/2008 | SKT | Davis | Promoted to active roster | | | Before |
| 5/3/2008 | SKT | Easley | Promoted to active roster | | | Before |
| 5/3/2008 | SKT | Giles,M | Promoted to active roster | | | Before |
| 5/3/2008 | SKT | Gonzalez | Demoted to reserve roster | | | Before |
| 5/3/2008 | SKT | MacDougal | Promoted to active roster | | | Before |
| 5/3/2008 | SKT | Miles | Demoted to reserve roster | | | Before |
| 5/3/2008 | SKT | Owings | Demoted to reserve roster | | | Before |
| 5/3/2008 | SKT | Rasner | Promoted to active roster | | | Before |
| 5/3/2008 | SKT | Schilling | Demoted to reserve roster | | | Before |
| 5/3/2008 | SKT | Trachsel | Promoted to active roster | | | Before |
| 5/4/2008 | PEA | De Aza | Promoted to active roster | | | Before |
| 5/4/2008 | PEA | Roberts | Placed on disabled list | | 5/5/2008 | Before |
| 5/5/2008 | B C | Murphy | Promoted to active roster | | | Before |
| 5/5/2008 | SID | Callaspo | Promoted to active roster | | | Before |
| 5/7/2008 | PIN | Bautista | Placed on disabled list | | 8/5/2008 | Before |
| 5/7/2008 | PIN | Cairo | Promoted to active roster | | | Before |
| 5/8/2008 | SID | Callaspo | Demoted to reserve roster | | | Before |
| 5/8/2008 | SID | Perez | Demoted to reserve roster | | | Before |
| 5/8/2008 | SID | Westbrook | Promoted to active roster | | | Before |
| 5/8/2008 | SKT | Gonzalez | Demoted to reserve roster | | | Before |
| 5/8/2008 | SKT | Mendoza | Promoted to active roster | | | Before |
| 5/8/2008 | SKT | Moseley | Demoted to reserve roster | | | Before |
| 5/8/2008 | SKT | O'Flaherty | Promoted to active roster | | | Before |
| 5/8/2008 | SKT | Owings | Promoted to active roster | | | Before |
| 5/8/2008 | SKT | Rasner | Demoted to reserve roster | | | Before |
| 5/8/2008 | SSX | Backe | Promoted to active roster | | | Before |
| 5/8/2008 | SSX | Humber | Demoted to reserve roster | | | Before |
| 5/9/2008 | MAI | Duke | Promoted to active roster | | | Before |
| 5/9/2008 | MAI | Fogg | Demoted to reserve roster | | | Before |
| 5/9/2008 | PEA | De Aza | Demoted to reserve roster | | | Before |
| 5/9/2008 | PEA | Frandsen | Promoted to active roster | | | Before |
| 5/9/2008 | PEA | Grudzielanek | Demoted to reserve roster | | | Before |
| 5/9/2008 | PEA | Roberts | Activated from disabled list | | | Before |
| 5/9/2008 | PHO | Gallardo | Demoted to reserve roster | | | Before |
| 5/9/2008 | PHO | Springer | Demoted to reserve roster | | | Before |
| 5/9/2008 | PHO | Vargas | Promoted to active roster | | | Before |
| 5/9/2008 | PHO | Wassermann | Promoted to active roster | | | Before |
| 5/9/2008 | PIN | Bautista | Activated from disabled list | | | Before |
| 5/9/2008 | PIN | Castro | Promoted to active roster | | | Before |
| 5/9/2008 | PIN | Diaz | Demoted to reserve roster | | | Before |
| 5/9/2008 | PIN | Feierabend | Promoted to active roster | | | Before |
| 5/9/2008 | PIN | Hawkins | Demoted to reserve roster | | | Before |
| 5/9/2008 | PIN | Looper | Promoted to active roster | | | Before |
| 5/9/2008 | PIN | Sheets | Demoted to reserve roster | | | Before |
| 5/9/2008 | PIN | Youkilis | Demoted to reserve roster | | | Before |
| 5/9/2008 | SCO | Casilla | Demoted to reserve roster | | | Before |
| 5/9/2008 | SCO | Hairston | Promoted to active roster | | | Before |
| 5/9/2008 | SCO | Lannan | Promoted to active roster | | | Before |
| 5/9/2008 | SCO | Marte | Promoted to active roster | | | Before |
| 5/9/2008 | SCO | McCarthy | Demoted to reserve roster | | | Before |
| 5/9/2008 | SCO | Pena | Demoted to reserve roster | | | Before |
| 5/11/2008 | PEA | De Aza | Promoted to active roster | | | Before |
| 5/11/2008 | PEA | Morneau | Placed on disabled list | | 5/12/2008 | Before |
| 5/11/2008 | PIN | Diaz | Promoted to active roster | | | Before |
| 5/11/2008 | PIN | Youkilis | Promoted to active roster | | | Before |
| 5/11/2008 | SID | Callaspo | Promoted to active roster | | | Before |
| 5/12/2008 | IRI | Lester | Promoted to active roster | | | Before |
| 5/12/2008 | IRI | Sosa | Demoted to reserve roster | | | Before |
| 5/12/2008 | PEA | Ramirez | Placed on disabled list | | 5/13/2008 | Before |
| 5/12/2008 | PEA | Zobrist | Promoted to active roster | | | Before |
| 5/12/2008 | PIN | Hawkins | Promoted to active roster | | | Before |
| 5/13/2008 | SKT | Blanco | Promoted to active roster | | | Before |
| 5/13/2008 | SKT | Treanor | Placed on disabled list | | 5/14/2008 | Before |
| 5/14/2008 | B C | Bergmann | Promoted to active roster | | | Before |
| 5/14/2008 | B C | Garza | Demoted to reserve roster | | | Before |
| 5/14/2008 | B C | Kuo | Demoted to reserve roster | | | Before |
| 5/14/2008 | B C | Loewen | Demoted to reserve roster | | | Before |
| 5/14/2008 | B C | Mitre | Promoted to active roster | | | Before |
| 5/14/2008 | B C | Murphy | Promoted to active roster | | | Before |
| 5/14/2008 | B C | Richar | Demoted to reserve roster | | | Before |
| 5/14/2008 | B C | Volquez | Promoted to active roster | | | Before |
| 5/14/2008 | MAI | Duke | Demoted to reserve roster | | | Before |
| 5/14/2008 | MAI | Fogg | Promoted to active roster | | | Before |
| 5/14/2008 | PEA | De Aza | Demoted to reserve roster | | | Before |
| 5/14/2008 | PEA | Frandsen | Demoted to reserve roster | | | Before |
| 5/14/2008 | PEA | Grudzielanek | Promoted to active roster | | | Before |
| 5/14/2008 | PEA | Morneau | Activated from disabled list | | | Before |
| 5/14/2008 | PEA | Ramirez | Activated from disabled list | | | Before |
| 5/14/2008 | PEA | Zobrist | Demoted to reserve roster | | | Before |
| 5/14/2008 | SKT | Treanor | Activated from disabled list | | | Before |
| 5/15/2008 | B C | Dukes | Promoted to active roster | | | Before |
| 5/15/2008 | B C | LaRoche | Demoted to reserve roster | | | Before |
| 5/15/2008 | PHO | Gallardo | Promoted to active roster | | | Before |
| 5/15/2008 | PHO | Hamels | Demoted to reserve roster | | | Before |
| 5/15/2008 | PHO | Keppinger | Demoted to reserve roster | | | Before |
| 5/15/2008 | PHO | Ludwick | Promoted to active roster | | | Before |
| 5/15/2008 | PIN | Castro | Demoted to reserve roster | | | Before |
| 5/15/2008 | PIN | Castro | Promoted to active roster | | | Before |
| 5/15/2008 | PIN | Diaz | Demoted to reserve roster | | | Before |
| 5/15/2008 | PIN | Feierabend | Demoted to reserve roster | | | Before |
| 5/15/2008 | PIN | Gomez | Demoted to reserve roster | | | Before |
| 5/15/2008 | PIN | Hernandez,O | Demoted to reserve roster | | | Before |
| 5/15/2008 | PIN | Sheets | Promoted to active roster | | | Before |
| 5/15/2008 | SCO | Hairston | Demoted to reserve roster | | | Before |
| 5/15/2008 | SCO | Pena | Promoted to active roster | | | Before |
| 5/15/2008 | SID | Ayala | Promoted to active roster | | | Before |
| 5/15/2008 | SID | Bradford | Demoted to reserve roster | | | Before |
| 5/15/2008 | SID | Buckner | Promoted to active roster | | | Before |
| 5/15/2008 | SID | Callaspo | Demoted to reserve roster | | | Before |
| 5/15/2008 | SID | Snyder | Demoted to reserve roster | | | Before |
| 5/15/2008 | SKT | Aurilia | Demoted to reserve roster | | | Before |
| 5/15/2008 | SKT | Davis | Demoted to reserve roster | | | Before |
| 5/15/2008 | SKT | Giles,M | Demoted to reserve roster | | | Before |
| 5/15/2008 | SKT | Gonzalez | Promoted to active roster | | | Before |
| 5/15/2008 | SKT | Mendoza | Demoted to reserve roster | | | Before |
| 5/15/2008 | SKT | Miles | Promoted to active roster | | | Before |
| 5/15/2008 | SKT | Schilling | Promoted to active roster | | | Before |
| 5/18/2008 | IRI | Counsell | Promoted to active roster | | | Before |
| 5/19/2008 | DRI | Barton | Promoted to active roster | | | Before |
| 5/19/2008 | DRI | Braun | Demoted to reserve roster | | | Before |
| 5/20/2008 | B C | Burgos | Promoted to active roster | | | Before |
| 5/20/2008 | B C | Dukes | Demoted to reserve roster | | | Before |
| 5/20/2008 | B C | LaRoche | Promoted to active roster | | | Before |
| 5/20/2008 | B C | Salazar | Promoted to active roster | | | Before |
| 5/20/2008 | B C | Tracy | Demoted to reserve roster | | | Before |
| 5/20/2008 | B C | Volquez | Demoted to reserve roster | | | Before |
| 5/20/2008 | IRI | Counsell | Demoted to reserve roster | | | Before |
| 5/20/2008 | MAI | Albaladejo | Promoted to active roster | | | Before |
| 5/20/2008 | MAI | Bynum | Demoted to reserve roster | | | Before |
| 5/20/2008 | SKT | Aurilia | Promoted to active roster | | | Before |
| 5/20/2008 | SKT | Blanco | Demoted to reserve roster | | | Before |
| 5/20/2008 | SKT | Giles,M | Promoted to active roster | | | Before |
| 5/20/2008 | SKT | Miles | Demoted to reserve roster | | | Before |
| 5/20/2008 | SKT | Rasner | Promoted to active roster | | | Before |
| 5/20/2008 | SKT | Schilling | Demoted to reserve roster | | | Before |
| 5/20/2008 | VIC | Freel | Demoted to reserve roster | | | Before |
| 5/20/2008 | VIC | Johnson | Demoted to reserve roster | | | Before |
| 5/20/2008 | VIC | Sanders | Promoted to active roster | | | Before |
| 5/20/2008 | VIC | Votto | Promoted to active roster | | | Before |
| 5/21/2008 | MAI | Bynum | Promoted to active roster | | | Before |
| 5/21/2008 | PHO | Hamels | Promoted to active roster | | | Before |
| 5/21/2008 | PHO | Jackson | Demoted to reserve roster | | | Before |
| 5/21/2008 | PHO | Springer | Promoted to active roster | | | Before |
| 5/21/2008 | PHO | Vargas | Demoted to reserve roster | | | Before |
| 5/21/2008 | PHO | Ward | Promoted to active roster | | | Before |
| 5/21/2008 | PHO | Wassermann | Demoted to reserve roster | | | Before |
| 5/21/2008 | PIN | Crawford | Demoted to reserve roster | | | Before |
| 5/21/2008 | PIN | Feierabend | Promoted to active roster | | | Before |
| 5/21/2008 | PIN | Hernandez,O | Promoted to active roster | | | Before |
| 5/21/2008 | PIN | Rogers | Demoted to reserve roster | | | Before |
| 5/21/2008 | PIN | Sheets | Demoted to reserve roster | | | Before |
| 5/21/2008 | PIN | Young | Promoted to active roster | | | Before |
| 5/21/2008 | SCO | Cameron,M | Demoted to reserve roster | | | Before |
| 5/21/2008 | SCO | Gonzalez,Ed | Promoted to active roster | | | Before |
| 5/21/2008 | SCO | Hairston | Promoted to active roster | | | Before |
| 5/21/2008 | SCO | Lannan | Demoted to reserve roster | | | Before |
| 5/21/2008 | SCO | McCarthy | Promoted to active roster | | | Before |
| 5/21/2008 | SCO | McGowan | Demoted to reserve roster | | | Before |
| 5/21/2008 | SKT | Miles | Promoted to active roster | | | Before |
| 5/24/2008 | VIC | Harden | Demoted to reserve roster | | | Before |
| 5/24/2008 | VIC | Wise | Promoted to active roster | | | Before |
| 5/27/2008 | MAI | Alfonzo | Demoted to reserve roster | | | Before |
| 5/27/2008 | MAI | Everett | Demoted to reserve roster | | | Before |
| 5/27/2008 | MAI | Everett | Promoted to active roster | | | Before |
| 5/27/2008 | MAI | Fogg | Demoted to reserve roster | | | Before |
| 5/27/2008 | MAI | Wilson | Promoted to active roster | | | Before |
| 5/27/2008 | PEA | De Aza | Promoted to active roster | | | Before |
| 5/27/2008 | PEA | Frandsen | Promoted to active roster | | | Before |
| 5/27/2008 | PEA | Grudzielanek | Demoted to reserve roster | | | Before |
| 5/27/2008 | PEA | Ramirez | Placed on disabled list | | 5/28/2008 | Before |
| 5/27/2008 | PIN | Cairo | Demoted to reserve roster | | | Before |
| 5/27/2008 | PIN | Castro | Demoted to reserve roster | | | Before |
| 5/27/2008 | PIN | Crawford | Promoted to active roster | | | Before |
| 5/27/2008 | PIN | Diaz | Promoted to active roster | | | Before |
| 5/27/2008 | PIN | Feierabend | Demoted to reserve roster | | | Before |
| 5/27/2008 | PIN | Gomez | Promoted to active roster | | | Before |
| 5/27/2008 | PIN | Hawkins | Demoted to reserve roster | | | Before |
| 5/27/2008 | PIN | Looper | Demoted to reserve roster | | | Before |
| 5/27/2008 | PIN | Rogers | Promoted to active roster | | | Before |
| 5/27/2008 | PIN | Sheets | Promoted to active roster | | | Before |
| 5/27/2008 | PIN | Thatcher | Promoted to active roster | | | Before |
| 5/27/2008 | PIN | Young | Demoted to reserve roster | | | Before |
| 5/27/2008 | SCO | Casilla | Promoted to active roster | | | Before |
| 5/27/2008 | SCO | Gonzalez,Ed | Demoted to reserve roster | | | Before |
| 5/27/2008 | SCO | Lannan | Promoted to active roster | | | Before |
| 5/27/2008 | SCO | Proctor | Demoted to reserve roster | | | Before |
| 5/27/2008 | SID | Howell | Demoted to reserve roster | | | Before |
| 5/27/2008 | SID | Perez | Promoted to active roster | | | Before |
| 5/27/2008 | SKT | Aurilia | Demoted to reserve roster | | | Before |
| 5/27/2008 | SKT | Damon | Promoted to active roster | | | Before |
| 5/27/2008 | SKT | Miles | Demoted to reserve roster | | | Before |
| 5/27/2008 | SKT | Moseley | Promoted to active roster | | | Before |
| 5/27/2008 | SKT | Rasner | Demoted to reserve roster | | | Before |
| 5/27/2008 | SKT | Sampson | Promoted to active roster | | | Before |
| 5/27/2008 | SKT | Schilling | Promoted to active roster | | | Before |
| 5/27/2008 | SKT | Taguchi | Demoted to reserve roster | | | Before |
| 5/27/2008 | SKT | Towers | Demoted to reserve roster | | | Before |
| 5/28/2008 | PEA | Bullington | Promoted to active roster | | | Before |
| 5/28/2008 | PEA | Maine | Placed on disabled list | | 5/29/2008 | Before |
| 5/30/2008 | IRI | Loaiza | Promoted to active roster | | | Before |
| 5/30/2008 | SKT | Buchholz | Promoted to active roster | | | Before |
| 5/30/2008 | SKT | Miles | Promoted to active roster | | | Before |
| 6/1/2008 | B C | Bergmann | Demoted to reserve roster | | | Before |
| 6/1/2008 | B C | Burgos | Demoted to reserve roster | | | Before |
| 6/1/2008 | B C | Floyd | Promoted to active roster | | | Before |
| 6/1/2008 | B C | Garza | Promoted to active roster | | | Before |
| 6/1/2008 | B C | Loewen | Promoted to active roster | | | Before |
| 6/1/2008 | B C | Mitre | Demoted to reserve roster | | | Before |
| 6/1/2008 | B C | Montero | Demoted to reserve roster | | | Before |
| 6/1/2008 | B C | Pena | Promoted to active roster | | | Before |
| 6/1/2008 | IRI | Loaiza | Demoted to reserve roster | | | Before |
| 6/1/2008 | PIN | Delcarmen | Demoted to reserve roster | | | Before |
| 6/1/2008 | PIN | Feierabend | Promoted to active roster | | | Before |
| 6/1/2008 | PIN | Hawkins | Promoted to active roster | | | Before |
| 6/1/2008 | PIN | Hernandez,O | Demoted to reserve roster | | | Before |
| 6/1/2008 | PIN | Looper | Promoted to active roster | | | Before |
| 6/1/2008 | PIN | Thatcher | Demoted to reserve roster | | | Before |
| 6/1/2008 | SCO | Lofton | Acquired via trade | ANR | | After |
| 6/1/2008 | SCO | Pena | Traded away | ANR | | After |
| 6/1/2008 | SKT | Giles,M | Demoted to reserve roster | | | Before |
| 6/1/2008 | SKT | Moseley | Demoted to reserve roster | | | Before |
| 6/2/2008 | PEA | Maine | Activated from disabled list | | | Before |
| 6/2/2008 | PEA | Ramirez | Activated from disabled list | | | Before |
| 6/3/2008 | MAI | Albaladejo | Demoted to reserve roster | | | Before |
| 6/3/2008 | MAI | Duke | Promoted to active roster | | | Before |
| 6/3/2008 | MAI | Fogg | Promoted to active roster | | | Before |
| 6/3/2008 | MAI | Saunders | Demoted to reserve roster | | | Before |
| 6/3/2008 | PEA | Bullington | Demoted to reserve roster | | | Before |
| 6/3/2008 | PEA | De Aza | Demoted to reserve roster | | | Before |
| 6/3/2008 | PEA | Frandsen | Demoted to reserve roster | | | Before |
| 6/3/2008 | PEA | Grudzielanek | Promoted to active roster | | | Before |
| 6/3/2008 | PEA | Jimenez | Promoted to active roster | | | Before |
| 6/3/2008 | PEA | Ojeda | Demoted to reserve roster | | | Before |
| 6/3/2008 | PHO | Gallardo | Demoted to reserve roster | | | Before |
| 6/3/2008 | PHO | Jackson | Promoted to active roster | | | Before |
| 6/3/2008 | PHO | Kent | Demoted to reserve roster | | | Before |
| 6/3/2008 | PHO | Seay | Promoted to active roster | | | Before |
| 6/3/2008 | PHO | Vargas | Promoted to active roster | | | Before |
| 6/3/2008 | PHO | Ward | Demoted to reserve roster | | | Before |
| 6/3/2008 | VIC | Bannister | Demoted to reserve roster | | | Before |
| 6/3/2008 | VIC | Hanrahan | Promoted to active roster | | | Before |
| 6/3/2008 | VIC | Morales | Promoted to active roster | | | Before |
| 6/3/2008 | VIC | Votto | Demoted to reserve roster | | | Before |
| 6/5/2008 | B C | Brown | Placed on disabled list | | 6/6/2008 | Before |
| 6/5/2008 | B C | Dukes | Promoted to active roster | | | Before |
| 6/8/2008 | B C | Bergmann | Promoted to active roster | | | Before |
| 6/8/2008 | B C | Davis | Demoted to reserve roster | | | Before |
| 6/8/2008 | B C | Dukes | Demoted to reserve roster | | | Before |
| 6/8/2008 | B C | Loewen | Demoted to reserve roster | | | Before |
| 6/8/2008 | B C | Misch | Demoted to reserve roster | | | Before |
| 6/8/2008 | B C | Mitre | Promoted to active roster | | | Before |
| 6/8/2008 | B C | Montero | Promoted to active roster | | | Before |
| 6/8/2008 | B C | Pena | Demoted to reserve roster | | | Before |
| 6/8/2008 | B C | Volquez | Promoted to active roster | | | Before |
| 6/8/2008 | PEA | Hirsh | Promoted to active roster | | | Before |
| 6/8/2008 | PEA | Lieber | Demoted to reserve roster | | | Before |
| 6/8/2008 | SCO | Cameron,M | Promoted to active roster | | | Before |
| 6/8/2008 | SCO | Hairston | Demoted to reserve roster | | | Before |
| 6/8/2008 | SCO | Lannan | Demoted to reserve roster | | | Before |
| 6/8/2008 | SCO | McGowan | Promoted to active roster | | | Before |
| 6/8/2008 | SKT | Aurilia | Promoted to active roster | | | Before |
| 6/8/2008 | SKT | Giles,M | Demoted to reserve roster | | | Before |
| 6/8/2008 | SKT | Giles,M | Promoted to active roster | | | Before |
| 6/8/2008 | SKT | Mora | Demoted to reserve roster | | | Before |
| 6/8/2008 | SKT | Mora | Promoted to active roster | | | Before |
| 6/8/2008 | SKT | Moseley | Promoted to active roster | | | Before |
| 6/8/2008 | SKT | Owings | Demoted to reserve roster | | | Before |
| 6/8/2008 | SKT | Reyes | Demoted to reserve roster | | | Before |
| 6/8/2008 | SKT | Schilling | Demoted to reserve roster | | | Before |
| 6/8/2008 | SKT | Taguchi | Promoted to active roster | | | Before |
| 6/8/2008 | SSX | Burres | Signed | | | Before |
| 6/8/2008 | SSX | Gomez | Promoted to active roster | | | Before |
| 6/8/2008 | SSX | Olson | Demoted to reserve roster | | | Before |
| 6/8/2008 | SSX | Olson | Promoted to active roster | | | Before |
| 6/8/2008 | SSX | Perkins | Demoted to reserve roster | | | Before |
| 6/8/2008 | SSX | Piazza | Released | | | Before |
| 6/9/2008 | B C | Brown | Activated from disabled list | | | Before |
| 6/9/2008 | B C | Dukes | Promoted to active roster | | | Before |
| 6/9/2008 | IRI | Counsell | Promoted to active roster | | | Before |
| 6/14/2008 | DRI | Johnson | Demoted to reserve roster | | | Before |
| 6/14/2008 | DRI | Maxwell | Promoted to active roster | | | Before |
| 6/14/2008 | MAI | Duke | Demoted to reserve roster | | | Before |
| 6/14/2008 | MAI | Saunders | Promoted to active roster | | | Before |
| 6/14/2008 | PHO | Cordero | Demoted to reserve roster | | | Before |
| 6/14/2008 | PHO | Cruz | Demoted to reserve roster | | | Before |
| 6/14/2008 | PHO | Embree | Demoted to reserve roster | | | Before |
| 6/14/2008 | PHO | Fuentes | Demoted to reserve roster | | | Before |
| 6/14/2008 | PHO | Hamels | Demoted to reserve roster | | | Before |
| 6/14/2008 | PHO | Hart | Promoted to active roster | | | Before |
| 6/14/2008 | PHO | Kent | Promoted to active roster | | | Before |
| 6/14/2008 | PHO | Keppinger | Promoted to active roster | | | Before |
| 6/14/2008 | PHO | Meyer | Promoted to active roster | | | Before |
| 6/14/2008 | PHO | Ohlendorf | Promoted to active roster | | | Before |
| 6/14/2008 | PHO | Rodney | Demoted to reserve roster | | | Before |
| 6/14/2008 | PHO | Sarfate | Promoted to active roster | | | Before |
| 6/14/2008 | PHO | Upton | Placed on disabled list | | 6/11/2008 | Before |
| 6/14/2008 | PHO | Wassermann | Promoted to active roster | | | Before |
| 6/14/2008 | PIN | Delcarmen | Promoted to active roster | | | Before |
| 6/14/2008 | PIN | Hawkins | Demoted to reserve roster | | | Before |
| 6/14/2008 | PIN | Hernandez,O | Demoted to reserve roster | | | Before |
| 6/14/2008 | PIN | Hernandez,O | Promoted to active roster | | | Before |
| 6/14/2008 | PIN | Wakefield | Demoted to reserve roster | | | Before |
| 6/14/2008 | PIN | Wakefield | Promoted to active roster | | | Before |
| 6/14/2008 | SSX | Backe | Demoted to reserve roster | | | Before |
| 6/14/2008 | SSX | Olson | Promoted to active roster | | | Before |
| 6/15/2008 | B C | Bush | Demoted to reserve roster | | | Before |
| 6/15/2008 | B C | Davis | Promoted to active roster | | | Before |
| 6/15/2008 | B C | Kuo | Promoted to active roster | | | Before |
| 6/15/2008 | B C | Misch | Promoted to active roster | | | Before |
| 6/15/2008 | B C | Monroe | Demoted to reserve roster | | | Before |
| 6/15/2008 | B C | Murphy | Demoted to reserve roster | | | Before |
| 6/15/2008 | B C | Peralta | Demoted to reserve roster | | | Before |
| 6/15/2008 | B C | Richar | Promoted to active roster | | | Before |
| 6/15/2008 | B C | Salazar | Demoted to reserve roster | | | Before |
| 6/15/2008 | B C | Tracy | Promoted to active roster | | | Before |
| 6/15/2008 | B C | Volquez | Demoted to reserve roster | | | Before |
| 6/15/2008 | IRI | Counsell | Demoted to reserve roster | | | Before |
| 6/15/2008 | IRI | Quintero | Signed | | | Before |
| 6/15/2008 | IRI | Quintero | Demoted to reserve roster | | | Before |
| 6/15/2008 | IRI | Snelling | Released | | | Before |
| 6/15/2008 | MAI | Adkins | Released | | | Before |
| 6/15/2008 | MAI | Bynum | Demoted to reserve roster | | | Before |
| 6/15/2008 | MAI | Heintz | Signed | | | Before |
| 6/15/2008 | PEA | De Aza | Promoted to active roster | | | Before |
| 6/15/2008 | PEA | Frandsen | Promoted to active roster | | | Before |
| 6/15/2008 | PEA | Jimenez | Demoted to reserve roster | | | Before |
| 6/15/2008 | PEA | Ramirez | Demoted to reserve roster | | | Before |
| 6/15/2008 | PHO | Embree | Promoted to active roster | | | Before |
| 6/15/2008 | PHO | Fuentes | Promoted to active roster | | | Before |
| 6/15/2008 | PHO | Gallardo | Promoted to active roster | | | Before |
| 6/15/2008 | PHO | Hamels | Promoted to active roster | | | Before |
| 6/15/2008 | PHO | Hart | Demoted to reserve roster | | | Before |
| 6/15/2008 | PHO | Huff | Demoted to reserve roster | | | Before |
| 6/15/2008 | PHO | Meyer | Demoted to reserve roster | | | Before |
| 6/15/2008 | PHO | Sarfate | Demoted to reserve roster | | | Before |
| 6/15/2008 | PHO | Upton | Activated from disabled list | | | Before |
| 6/15/2008 | PHO | Wassermann | Demoted to reserve roster | | | Before |
| 6/15/2008 | SID | Bradford | Promoted to active roster | | | Before |
| 6/15/2008 | SID | Buckner | Demoted to reserve roster | | | Before |
| 6/15/2008 | SID | Garcia,F | Promoted to active roster | | | Before |
| 6/15/2008 | SID | Lewis | Demoted to reserve roster | | | Before |
| 6/15/2008 | SKT | Buchholz | Demoted to reserve roster | | | Before |
| 6/15/2008 | SKT | Moseley | Demoted to reserve roster | | | Before |
| 6/15/2008 | SKT | Schilling | Promoted to active roster | | | Before |
| 6/15/2008 | SKT | Towers | Promoted to active roster | | | Before |
| 6/15/2008 | VIC | Bannister | Promoted to active roster | | | Before |
| 6/15/2008 | VIC | Byrd | Demoted to reserve roster | | | Before |
| 6/15/2008 | VIC | Duncan | Demoted to reserve roster | | | Before |
| 6/16/2008 | PIN | Cairo | Promoted to active roster | | | Before |
| 6/22/2008 | B C | Bush | Promoted to active roster | | | Before |
| 6/22/2008 | B C | Davis | Demoted to reserve roster | | | Before |
| 6/22/2008 | DRI | Barton | Demoted to reserve roster | | | Before |
| 6/22/2008 | DRI | Cantu | Demoted to reserve roster | | | Before |
| 6/22/2008 | DRI | Lincecum | Promoted to active roster | | | Before |
| 6/22/2008 | DRI | Ryan | Promoted to active roster | | | Before |
| 6/22/2008 | PEA | De Aza | Demoted to reserve roster | | | Before |
| 6/22/2008 | PEA | Frandsen | Demoted to reserve roster | | | Before |
| 6/22/2008 | PEA | Jimenez | Promoted to active roster | | | Before |
| 6/22/2008 | PEA | Ramirez | Promoted to active roster | | | Before |
| 6/22/2008 | PHO | Cordero | Promoted to active roster | | | Before |
| 6/22/2008 | PHO | Embree | Demoted to reserve roster | | | Before |
| 6/22/2008 | PHO | Gallardo | Demoted to reserve roster | | | Before |
| 6/22/2008 | PHO | Huff | Promoted to active roster | | | Before |
| 6/22/2008 | PHO | Keppinger | Demoted to reserve roster | | | Before |
| 6/22/2008 | PHO | Ohlendorf | Demoted to reserve roster | | | Before |
| 6/22/2008 | PHO | Sarfate | Promoted to active roster | | | Before |
| 6/22/2008 | PHO | Wassermann | Promoted to active roster | | | Before |
| 6/22/2008 | PIN | Gomez | Demoted to reserve roster | | | Before |
| 6/22/2008 | PIN | Rogers | Demoted to reserve roster | | | Before |
| 6/22/2008 | PIN | Thatcher | Promoted to active roster | | | Before |
| 6/22/2008 | SCO | Gonzalez,Ed | Promoted to active roster | | | Before |
| 6/22/2008 | SCO | Hairston | Promoted to active roster | | | Before |
| 6/22/2008 | SCO | Hudson | Demoted to reserve roster | | | Before |
| 6/22/2008 | SCO | Marte | Demoted to reserve roster | | | Before |
| 6/22/2008 | SCO | McGowan | Demoted to reserve roster | | | Before |
| 6/22/2008 | SCO | Proctor | Promoted to active roster | | | Before |
| 6/22/2008 | SKT | Buchholz | Promoted to active roster | | | Before |
| 6/22/2008 | SKT | Owings | Promoted to active roster | | | Before |
| 6/22/2008 | SKT | Reyes | Promoted to active roster | | | Before |
| 6/22/2008 | SKT | Sampson | Demoted to reserve roster | | | Before |
| 6/22/2008 | SKT | Trachsel | Demoted to reserve roster | | | Before |
| 6/22/2008 | SKT | Walker | Demoted to reserve roster | | | Before |
| 6/24/2008 | B C | Volquez | Promoted to active roster | | | Before |
| 6/28/2008 | B C | Davis | Promoted to active roster | | | Before |
| 6/28/2008 | B C | Dukes | Demoted to reserve roster | | | Before |
| 6/28/2008 | B C | Floyd | Demoted to reserve roster | | | Before |
| 6/28/2008 | B C | Garza | Demoted to reserve roster | | | Before |
| 6/28/2008 | B C | Johnson | Demoted to reserve roster | | | Before |
| 6/28/2008 | B C | Monroe | Promoted to active roster | | | Before |
| 6/28/2008 | B C | Murphy | Promoted to active roster | | | Before |
| 6/28/2008 | B C | Peralta | Promoted to active roster | | | Before |
| 6/28/2008 | B C | Volquez | Demoted to reserve roster | | | Before |
| 6/28/2008 | DRI | Erstad | Signed | | | Before |
| 6/28/2008 | DRI | Hamilton | Demoted to reserve roster | | | Before |
| 6/28/2008 | DRI | Maroth | Released | | | Before |
| 6/28/2008 | DRI | Wood | Promoted to active roster | | | Before |
| 6/28/2008 | MAI | Abercrombie | Promoted to active roster | | | Before |
| 6/28/2008 | MAI | Albaladejo | Promoted to active roster | | | Before |
| 6/28/2008 | MAI | Duke | Promoted to active roster | | | Before |
| 6/28/2008 | MAI | Molina | Demoted to reserve roster | | | Before |
| 6/28/2008 | MAI | Redding | Demoted to reserve roster | | | Before |
| 6/28/2008 | MAI | Schroder | Demoted to reserve roster | | | Before |
| 6/28/2008 | PHO | Cordero | Demoted to reserve roster | | | Before |
| 6/28/2008 | PHO | Crisp | Demoted to reserve roster | | | Before |
| 6/28/2008 | PHO | Cruz | Promoted to active roster | | | Before |
| 6/28/2008 | PHO | Embree | Promoted to active roster | | | Before |
| 6/28/2008 | PHO | Gallardo | Promoted to active roster | | | Before |
| 6/28/2008 | PHO | Huff | Demoted to reserve roster | | | Before |
| 6/28/2008 | PHO | Huff | Promoted to active roster | | | Before |
| 6/28/2008 | PHO | Keppinger | Promoted to active roster | | | Before |
| 6/28/2008 | PHO | Rodney | Demoted to reserve roster | | | Before |
| 6/28/2008 | PHO | Rodney | Promoted to active roster | | | Before |
| 6/28/2008 | PHO | Sarfate | Demoted to reserve roster | | | Before |
| 6/28/2008 | PHO | Ward | Promoted to active roster | | | Before |
| 6/28/2008 | PHO | Wassermann | Demoted to reserve roster | | | Before |
| 6/28/2008 | PIN | Delcarmen | Demoted to reserve roster | | | Before |
| 6/28/2008 | PIN | Hawkins | Promoted to active roster | | | Before |
| 6/28/2008 | PIN | Hernandez,O | Promoted to active roster | | | Before |
| 6/28/2008 | PIN | Rogers | Promoted to active roster | | | Before |
| 6/28/2008 | PIN | Thatcher | Demoted to reserve roster | | | Before |
| 6/28/2008 | PIN | Wakefield | Demoted to reserve roster | | | Before |
| 6/28/2008 | SCO | Gonzalez,Ed | Promoted to active roster | | | Before |
| 6/28/2008 | SCO | Marte | Demoted to reserve roster | | | Before |
| 6/28/2008 | SCO | McCarthy | Demoted to reserve roster | | | Before |
| 6/28/2008 | SCO | Proctor | Promoted to active roster | | | Before |
| 6/28/2008 | SKT | Damon | Demoted to reserve roster | | | Before |
| 6/28/2008 | SKT | Owings | Demoted to reserve roster | | | Before |
| 6/28/2008 | SKT | Rasner | Promoted to active roster | | | Before |
| 6/28/2008 | SKT | Sampson | Promoted to active roster | | | Before |
| 6/29/2008 | B C | Johnson | Promoted to active roster | | | Before |
| 6/30/2008 | PIN | Delcarmen | Promoted to active roster | | | Before |
| 7/2/2008 | B C | Pena | Promoted to active roster | | | Before |
| 7/2/2008 | SCO | Marte | Promoted to active roster | | | Before |
| 7/3/2008 | MAI | Abercrombie | Demoted to reserve roster | | | Before |
| 7/3/2008 | MAI | Donnelly | Signed | | | Before |
| 7/3/2008 | MAI | Duke | Demoted to reserve roster | | | Before |
| 7/3/2008 | MAI | Redding | Promoted to active roster | | | Before |
| 7/3/2008 | MAI | Sanchez | Released | | | Before |
| 7/3/2008 | PEA | De Aza | Promoted to active roster | | | Before |
| 7/3/2008 | PEA | Frandsen | Promoted to active roster | | | Before |
| 7/3/2008 | PEA | Grudzielanek | Demoted to reserve roster | | | Before |
| 7/3/2008 | PEA | Victorino | Demoted to reserve roster | | | Before |
| 7/3/2008 | SCO | Casilla | Demoted to reserve roster | | | Before |
| 7/3/2008 | SCO | Gonzalez,Ed | Demoted to reserve roster | | | Before |
| 7/3/2008 | SCO | Lannan | Promoted to active roster | | | Before |
| 7/3/2008 | SKT | Moseley | Promoted to active roster | | | Before |
| 7/3/2008 | SKT | Owings | Promoted to active roster | | | Before |
| 7/3/2008 | SKT | Rasner | Demoted to reserve roster | | | Before |
| 7/3/2008 | SKT | Sampson | Demoted to reserve roster | | | Before |
| 7/3/2008 | SKT | Schilling | Demoted to reserve roster | | | Before |
| 7/3/2008 | SKT | Schilling | Promoted to active roster | | | Before |
| 7/3/2008 | SKT | Towers | Demoted to reserve roster | | | Before |
| 7/3/2008 | SKT | Trachsel | Promoted to active roster | | | Before |
| 7/4/2008 | B C | Iwamura | Demoted to reserve roster | | | Before |
| 7/4/2008 | B C | Pena | Demoted to reserve roster | | | Before |
| 7/4/2008 | IRI | Counsell | Promoted to active roster | | | Before |
| 7/4/2008 | PHO | Cordero | Promoted to active roster | | | Before |
| 7/4/2008 | PHO | Crisp | Promoted to active roster | | | Before |
| 7/4/2008 | PHO | Gallardo | Demoted to reserve roster | | | Before |
| 7/4/2008 | PHO | Keppinger | Demoted to reserve roster | | | Before |
| 7/4/2008 | PHO | Ward | Demoted to reserve roster | | | Before |
| 7/4/2008 | PIN | Ankiel | Demoted to reserve roster | | | Before |
| 7/4/2008 | PIN | Delcarmen | Demoted to reserve roster | | | Before |
| 7/4/2008 | PIN | Gotay | Promoted to active roster | | | Before |
| 7/4/2008 | PIN | Sheets | Demoted to reserve roster | | | Before |
| 7/4/2008 | PIN | Wakefield | Promoted to active roster | | | Before |
| 7/4/2008 | SID | Shoppach | Promoted to active roster | | | Before |
| 7/4/2008 | SSX | Murphy | Promoted to active roster | | | Before |
| 7/4/2008 | SSX | Street | Demoted to reserve roster | | | Before |
| 7/4/2008 | SSX | Street | Promoted to active roster | | | Before |
| 7/4/2008 | SSX | Teahen | Demoted to reserve roster | | | Before |
| 7/7/2008 | IRI | Counsell | Demoted to reserve roster | | | Before |
| 7/9/2008 | IRI | Pignatiello | Released | | | Before |
| 7/9/2008 | IRI | Granderson | Acquired via trade | HEN | | After |
| 7/9/2008 | IRI | Lester | Traded away | HEN | | After |
| 7/9/2008 | IRI | Smoltz | Acquired via trade | HEN | | After |
| 7/9/2008 | MAI | Lieberthal | Signed | | | Before |
| 7/9/2008 | MAI | Wilson | Released | | | Before |
| 7/9/2008 | PHO | Dillon | Signed | | | Before |
| 7/9/2008 | PHO | Huber | Released | | | Before |
| 7/9/2008 | PHO | Mackowiak | Signed | | | Before |
| 7/9/2008 | PHO | Meyer | Released | | | Before |
| 7/9/2008 | PHO | Ohlendorf | Released | | | Before |
| 7/9/2008 | PHO | Taschner | Signed | | | Before |
| 7/9/2008 | SCO | Gonzalez,Ed | Promoted to active roster | | | Before |
| 7/9/2008 | SCO | Lannan | Demoted to reserve roster | | | Before |
| 7/9/2008 | SCO | Nippert | Promoted to active roster | | | Before |
| 7/9/2008 | SCO | Proctor | Demoted to reserve roster | | | Before |
| 7/10/2008 | DRI | Hammel | Demoted to reserve roster | | | Before |
| 7/10/2008 | DRI | Maxwell | Demoted to reserve roster | | | Before |
| 7/10/2008 | DRI | Petit | Demoted to reserve roster | | | Before |
| 7/10/2008 | DRI | Ryan | Demoted to reserve roster | | | Before |
| 7/10/2008 | IRI | Pierre | Demoted to reserve roster | | | Before |
| 7/10/2008 | IRI | Smoltz | Promoted to active roster | | | Before |
| 7/10/2008 | MAI | Abercrombie | Promoted to active roster | | | Before |
| 7/10/2008 | MAI | Albaladejo | Demoted to reserve roster | | | Before |
| 7/10/2008 | MAI | Duke | Promoted to active roster | | | Before |
| 7/10/2008 | MAI | Pence | Demoted to reserve roster | | | Before |
| 7/10/2008 | MAI | Saunders | Demoted to reserve roster | | | Before |
| 7/10/2008 | PEA | De Aza | Demoted to reserve roster | | | Before |
| 7/10/2008 | PEA | Victorino | Promoted to active roster | | | Before |
| 7/10/2008 | PHO | Kubel | Demoted to reserve roster | | | Before |
| 7/10/2008 | PHO | Ludwick | Demoted to reserve roster | | | Before |
| 7/10/2008 | PHO | Taschner | Demoted to reserve roster | | | Before |
| 7/10/2008 | PIN | Delcarmen | Promoted to active roster | | | Before |
| 7/10/2008 | PIN | Dempster | Demoted to reserve roster | | | Before |
| 7/10/2008 | SID | Shoppach | Demoted to reserve roster | | | Before |
| 7/10/2008 | SKT | Buchholz | Demoted to reserve roster | | | Before |
| 7/10/2008 | SKT | Cabrera | Demoted to reserve roster | | | Before |
| 7/10/2008 | SKT | Damon | Promoted to active roster | | | Before |
| 7/10/2008 | SKT | Moseley | Demoted to reserve roster | | | Before |
| 7/10/2008 | SKT | Sampson | Promoted to active roster | | | Before |
| 7/10/2008 | SKT | Walker | Promoted to active roster | | | Before |
| 7/14/2008 | PEA | Frandsen | Demoted to reserve roster | | | Before |
| 7/14/2008 | PEA | Grudzielanek | Promoted to active roster | | | Before |
| 7/14/2008 | VIC | Freel | Promoted to active roster | | | Before |
| 7/15/2008 | SCO | Bourn | Traded away | BST | | After |
| 7/16/2008 | B C | Iwamura | Promoted to active roster | | | Before |
| 7/16/2008 | B C | Tracy | Demoted to reserve roster | | | Before |
| 7/16/2008 | DRI | Braun | Released | | | Before |
| 7/16/2008 | DRI | Encarnacion | Signed | | | Before |
| 7/16/2008 | DRI | Karstens | Released | | | Before |
| 7/16/2008 | DRI | McDonald | Released | | | Before |
| 7/16/2008 | DRI | Vazquez | Signed | | | Before |
| 7/16/2008 | DRI | Vizquel | Signed | | | Before |
| 7/16/2008 | MAI | Duke | Demoted to reserve roster | | | Before |
| 7/16/2008 | MAI | Heintz | Demoted to reserve roster | | | Before |
| 7/16/2008 | MAI | Melhuse | Signed | | | Before |
| 7/16/2008 | MAI | Murphy | Released | | | Before |
| 7/16/2008 | MAI | Saunders | Promoted to active roster | | | Before |
| 7/16/2008 | PHO | Cordero | Demoted to reserve roster | | | Before |
| 7/16/2008 | PHO | Dillon | Demoted to reserve roster | | | Before |
| 7/16/2008 | PHO | Gallardo | Promoted to active roster | | | Before |
| 7/16/2008 | PHO | Keppinger | Promoted to active roster | | | Before |
| 7/16/2008 | PHO | Kubel | Promoted to active roster | | | Before |
| 7/16/2008 | PHO | Mackowiak | Demoted to reserve roster | | | Before |
| 7/16/2008 | PIN | Ankiel | Promoted to active roster | | | Before |
| 7/16/2008 | PIN | Cairo | Demoted to reserve roster | | | Before |
| 7/16/2008 | PIN | Castro | Promoted to active roster | | | Before |
| 7/16/2008 | PIN | Dempster | Promoted to active roster | | | Before |
| 7/16/2008 | PIN | Hawkins | Demoted to reserve roster | | | Before |
| 7/16/2008 | PIN | Hernandez,O | Demoted to reserve roster | | | Before |
| 7/16/2008 | PIN | Logan | Demoted to reserve roster | | | Before |
| 7/16/2008 | PIN | Rogers | Demoted to reserve roster | | | Before |
| 7/16/2008 | PIN | Sheets | Promoted to active roster | | | Before |
| 7/16/2008 | PIN | Thatcher | Promoted to active roster | | | Before |
| 7/16/2008 | SCO | Hairston | Promoted to active roster | | | Before |
| 7/16/2008 | SCO | Werth | Demoted to reserve roster | | | Before |
| 7/16/2008 | SID | Flores | Demoted to reserve roster | | | Before |
| 7/16/2008 | SID | Shoppach | Promoted to active roster | | | Before |
| 7/21/2008 | MAI | Fultz | Demoted to reserve roster | | | Before |
| 7/21/2008 | MAI | Pence | Promoted to active roster | | | Before |
| 7/21/2008 | MAI | Redding | Demoted to reserve roster | | | Before |
| 7/23/2008 | B C | Dellucci | Demoted to reserve roster | | | Before |
| 7/23/2008 | B C | Dukes | Promoted to active roster | | | Before |
| 7/23/2008 | MAI | Abercrombie | Demoted to reserve roster | | | Before |
| 7/23/2008 | MAI | Albaladejo | Released | | | Before |
| 7/23/2008 | MAI | Coutlangus | Signed | | | Before |
| 7/23/2008 | MAI | Coutlangus | Demoted to reserve roster | | | Before |
| 7/23/2008 | MAI | Dohmann | Signed | | | Before |
| 7/23/2008 | MAI | Dohmann | Demoted to reserve roster | | | Before |
| 7/23/2008 | MAI | Duke | Promoted to active roster | | | Before |
| 7/23/2008 | MAI | Grilli | Signed | | | Before |
| 7/23/2008 | MAI | Heintz | Released | | | Before |
| 7/23/2008 | MAI | Redding | Released | | | Before |
| 7/23/2008 | PHO | Cordero | Promoted to active roster | | | Before |
| 7/23/2008 | PHO | Hamels | Demoted to reserve roster | | | Before |
| 7/23/2008 | PIN | Delcarmen | Demoted to reserve roster | | | Before |
| 7/23/2008 | PIN | Hawkins | Promoted to active roster | | | Before |
| 7/23/2008 | SCO | Clark | Signed | | | Before |
| 7/23/2008 | SCO | Clark | Demoted to reserve roster | | | Before |
| 7/23/2008 | SID | Callaspo | Promoted to active roster | | | Before |
| 7/23/2008 | SKT | Buchholz | Promoted to active roster | | | Before |
| 7/23/2008 | SKT | Cabrera | Promoted to active roster | | | Before |
| 7/23/2008 | SKT | Gonzalez | Promoted to active roster | | | Before |
| 7/23/2008 | SKT | Moseley | Promoted to active roster | | | Before |
| 7/23/2008 | SKT | Reyes | Demoted to reserve roster | | | Before |
| 7/23/2008 | SKT | Sampson | Demoted to reserve roster | | | Before |
| 7/23/2008 | SKT | Schilling | Demoted to reserve roster | | | Before |
| 7/23/2008 | SKT | Taguchi | Demoted to reserve roster | | | Before |
| 7/24/2008 | PEA | Frandsen | Promoted to active roster | | | Before |
| 7/24/2008 | PEA | Lowell | Placed on disabled list | | 7/25/2008 | Before |
| 7/24/2008 | SSX | Teahen | Promoted to active roster | | | Before |
| 7/26/2008 | PIN | Castillo | Placed on disabled list | | 7/27/2008 | Before |
| 7/26/2008 | PIN | Gomez | Promoted to active roster | | | Before |
| 7/27/2008 | B C | Garza | Promoted to active roster | | | Before |
| 7/27/2008 | SSX | Teahen | Demoted to reserve roster | | | Before |
| 7/28/2008 | PEA | Acosta | Promoted to active roster | | | Before |
| 7/28/2008 | PEA | Frandsen | Demoted to reserve roster | | | Before |
| 7/28/2008 | PEA | Jimenez | Demoted to reserve roster | | | Before |
| 7/28/2008 | PEA | Percival | Demoted to reserve roster | | | Before |
| 7/28/2008 | PEA | Zobrist | Promoted to active roster | | | Before |
| 7/28/2008 | PHO | Huff | Traded away | BOU | | After |
| 7/28/2008 | PHO | Pena | Acquired via trade | BOU | | After |
| 7/28/2008 | SSX | Bacsik | Signed | | | Before |
| 7/28/2008 | SSX | Braden | Demoted to reserve roster | | | Before |
| 7/28/2008 | SSX | Eveland | Promoted to active roster | | | Before |
| 7/28/2008 | SSX | Floyd | Released | | | Before |
| 7/28/2008 | SSX | Humber | Released | | | Before |
| 7/28/2008 | SSX | Loe | Signed | | | Before |
| 7/28/2008 | SSX | Marshall | Demoted to reserve roster | | | Before |
| 7/28/2008 | SSX | Pearce | Promoted to active roster | | | Before |
| 7/28/2008 | SSX | Reyes | Demoted to reserve roster | | | Before |
| 7/28/2008 | SSX | Street | Demoted to reserve roster | | | Before |
| 7/28/2008 | SSX | Teahen | Promoted to active roster | | | Before |
| 7/28/2008 | VIC | Dotel | Demoted to reserve roster | | | Before |
| 7/28/2008 | VIC | Ellsbury | Demoted to reserve roster | | | Before |
| 7/28/2008 | VIC | Johnson | Promoted to active roster | | | Before |
| 7/28/2008 | VIC | Rosario | Promoted to active roster | | | Before |
| 7/28/2008 | VIC | Sanders | Demoted to reserve roster | | | Before |
| 7/29/2008 | B C | Kuo | Demoted to reserve roster | | | Before |
| 7/29/2008 | B C | Volquez | Demoted to reserve roster | | | Before |
| 7/29/2008 | B C | Volquez | Promoted to active roster | | | Before |
| 7/29/2008 | IRI | Lee | Demoted to reserve roster | | | Before |
| 7/29/2008 | IRI | Pierre | Promoted to active roster | | | Before |
| 7/29/2008 | IRI | Sexson | Promoted to active roster | | | Before |
| 7/29/2008 | IRI | Thames | Demoted to reserve roster | | | Before |
| 7/29/2008 | MAI | Dohmann | Promoted to active roster | | | Before |
| 7/29/2008 | MAI | Duke | Demoted to reserve roster | | | Before |
| 7/29/2008 | PEA | Jimenez | Released | | | Before |
| 7/29/2008 | PEA | Jimenez | Signed | | | Before |
| 7/29/2008 | PEA | Lopez | Released | | | Before |
| 7/29/2008 | PEA | Lopez | Signed | | | Before |
| 7/29/2008 | PEA | Lowell | Activated from disabled list | | | Before |
| 7/29/2008 | PHO | Dillon | Promoted to active roster | | | Before |
| 7/29/2008 | PHO | Fuentes | Demoted to reserve roster | | | Before |
| 7/29/2008 | PHO | Gallardo | Demoted to reserve roster | | | Before |
| 7/29/2008 | PHO | Hamels | Promoted to active roster | | | Before |
| 7/29/2008 | PHO | Hart | Promoted to active roster | | | Before |
| 7/29/2008 | PHO | Kent | Demoted to reserve roster | | | Before |
| 7/29/2008 | PHO | Keppinger | Demoted to reserve roster | | | Before |
| 7/29/2008 | PHO | Mackowiak | Promoted to active roster | | | Before |
| 7/29/2008 | PHO | Pena | Demoted to reserve roster | | | Before |
| 7/29/2008 | PHO | Seay | Demoted to reserve roster | | | Before |
| 7/29/2008 | PHO | Taschner | Promoted to active roster | | | Before |
| 7/29/2008 | PHO | Ward | Promoted to active roster | | | Before |
| 7/29/2008 | PIN | Castillo | Activated from disabled list | | | Before |
| 7/29/2008 | PIN | Diaz | Demoted to reserve roster | | | Before |
| 7/29/2008 | PIN | Gotay | Demoted to reserve roster | | | Before |
| 7/29/2008 | PIN | Gotay | Promoted to active roster | | | Before |
| 7/29/2008 | PIN | Hawkins | Demoted to reserve roster | | | Before |
| 7/29/2008 | PIN | Rogers | Promoted to active roster | | | Before |
| 7/29/2008 | PIN | Young | Promoted to active roster | | | Before |
| 7/29/2008 | SID | Callaspo | Demoted to reserve roster | | | Before |
| 7/29/2008 | SKT | Brocail | Demoted to reserve roster | | | Before |
| 7/29/2008 | SKT | Buchholz | Demoted to reserve roster | | | Before |
| 7/29/2008 | SKT | Mendoza | Promoted to active roster | | | Before |
| 7/29/2008 | SKT | Mora | Demoted to reserve roster | | | Before |
| 7/29/2008 | SKT | Rasner | Promoted to active roster | | | Before |
| 7/29/2008 | SKT | Taguchi | Promoted to active roster | | | Before |
| 7/30/2008 | PIN | Logan | Promoted to active roster | | | Before |
| 8/3/2008 | VIC | Byrd | Promoted to active roster | | | Before |
| 8/3/2008 | VIC | Mastny | Demoted to reserve roster | | | Before |
| 8/3/2008 | VIC | Osoria | Demoted to reserve roster | | | Before |
| 8/3/2008 | VIC | Votto | Promoted to active roster | | | Before |
| 8/4/2008 | IRI | Patterson | Released | | | Before |
| 8/4/2008 | IRI | Slaten | Signed | | | Before |
| 8/4/2008 | IRI | Slaten | Demoted to reserve roster | | | Before |
| 8/4/2008 | IRI | Sosa | Promoted to active roster | | | Before |
| 8/4/2008 | IRI | Wang | Demoted to reserve roster | | | Before |
| 8/4/2008 | MAI | Abercrombie | Demoted to reserve roster | | | Before |
| 8/4/2008 | MAI | Abercrombie | Promoted to active roster | | | Before |
| 8/4/2008 | MAI | Chacin | Signed | | | Before |
| 8/4/2008 | MAI | Coutlangus | Promoted to active roster | | | Before |
| 8/4/2008 | MAI | Downs | Demoted to reserve roster | | | Before |
| 8/4/2008 | MAI | Duke | Promoted to active roster | | | Before |
| 8/4/2008 | MAI | Langerhans | Released | | | Before |
| 8/4/2008 | MAI | Perez | Demoted to reserve roster | | | Before |
| 8/4/2008 | MAI | Saunders | Demoted to reserve roster | | | Before |
| 8/4/2008 | PEA | Jimenez | Demoted to reserve roster | | | Before |
| 8/4/2008 | PEA | Zobrist | Demoted to reserve roster | | | Before |
| 8/4/2008 | PEA | Zobrist | Promoted to active roster | | | Before |
| 8/4/2008 | PHO | Crisp | Demoted to reserve roster | | | Before |
| 8/4/2008 | PHO | Embree | Demoted to reserve roster | | | Before |
| 8/4/2008 | PHO | Hart | Demoted to reserve roster | | | Before |
| 8/4/2008 | PHO | Kent | Promoted to active roster | | | Before |
| 8/4/2008 | PHO | Ludwick | Demoted to reserve roster | | | Before |
| 8/4/2008 | PHO | Ludwick | Promoted to active roster | | | Before |
| 8/4/2008 | PHO | Pena | Promoted to active roster | | | Before |
| 8/4/2008 | PHO | Rodney | Promoted to active roster | | | Before |
| 8/4/2008 | PHO | Seay | Promoted to active roster | | | Before |
| 8/4/2008 | PHO | Ward | Demoted to reserve roster | | | Before |
| 8/4/2008 | PIN | Castro | Demoted to reserve roster | | | Before |
| 8/4/2008 | PIN | Feierabend | Demoted to reserve roster | | | Before |
| 8/4/2008 | PIN | Gallagher | Promoted to active roster | | | Before |
| 8/4/2008 | PIN | Hernandez,O | Promoted to active roster | | | Before |
| 8/4/2008 | PIN | Sheets | Demoted to reserve roster | | | Before |
| 8/4/2008 | PIN | Young | Demoted to reserve roster | | | Before |
| 8/4/2008 | SCO | Casilla | Promoted to active roster | | | Before |
| 8/4/2008 | SCO | Gonzalez,Ed | Demoted to reserve roster | | | Before |
| 8/4/2008 | SCO | Hairston | Demoted to reserve roster | | | Before |
| 8/4/2008 | SCO | McCarthy | Promoted to active roster | | | Before |
| 8/4/2008 | SCO | Nippert | Demoted to reserve roster | | | Before |
| 8/4/2008 | SCO | Werth | Promoted to active roster | | | Before |
| 8/4/2008 | SID | Callaspo | Promoted to active roster | | | Before |
| 8/4/2008 | SID | Figgins | Demoted to reserve roster | | | Before |
| 8/4/2008 | SID | Garcia,F | Demoted to reserve roster | | | Before |
| 8/4/2008 | SID | Lewis | Demoted to reserve roster | | | Before |
| 8/4/2008 | SID | Parra | Promoted to active roster | | | Before |
| 8/4/2008 | SID | Schierholtz | Promoted to active roster | | | Before |
| 8/4/2008 | SKT | Matsuzaka | Demoted to reserve roster | | | Before |
| 8/4/2008 | SKT | Mendoza | Demoted to reserve roster | | | Before |
| 8/4/2008 | SKT | Miles | Demoted to reserve roster | | | Before |
| 8/4/2008 | SKT | Mora | Promoted to active roster | | | Before |
| 8/4/2008 | SKT | Rasner | Demoted to reserve roster | | | Before |
| 8/4/2008 | SKT | Sampson | Promoted to active roster | | | Before |
| 8/4/2008 | SKT | Schilling | Promoted to active roster | | | Before |
| 8/4/2008 | SKT | Towers | Promoted to active roster | | | Before |
| 8/6/2008 | SCO | Hairston | Promoted to active roster | | | Before |
| 8/7/2008 | SID | Flores | Promoted to active roster | | | Before |
| 8/10/2008 | B C | Burgos | Promoted to active roster | | | Before |
| 8/10/2008 | B C | Garza | Demoted to reserve roster | | | Before |
| 8/10/2008 | B C | Kuo | Promoted to active roster | | | Before |
| 8/10/2008 | B C | Misch | Demoted to reserve roster | | | Before |
| 8/10/2008 | B C | Montero | Demoted to reserve roster | | | Before |
| 8/10/2008 | B C | Pena | Promoted to active roster | | | Before |
| 8/10/2008 | B C | Peralta | Demoted to reserve roster | | | Before |
| 8/10/2008 | B C | Richar | Demoted to reserve roster | | | Before |
| 8/10/2008 | B C | Tracy | Promoted to active roster | | | Before |
| 8/10/2008 | B C | Volquez | Promoted to active roster | | | Before |
| 8/10/2008 | DRI | Belisle | Released | | | Before |
| 8/10/2008 | DRI | Bonifacio | Demoted to reserve roster | | | Before |
| 8/10/2008 | DRI | Carpenter | Promoted to active roster | | | Before |
| 8/10/2008 | DRI | Conine | Signed | | | Before |
| 8/10/2008 | DRI | Costa | Demoted to reserve roster | | | Before |
| 8/10/2008 | DRI | Doumit | Demoted to reserve roster | | | Before |
| 8/10/2008 | DRI | Fields | Demoted to reserve roster | | | Before |
| 8/10/2008 | DRI | Glover | Signed | | | Before |
| 8/10/2008 | DRI | Guzman | Released | | | Before |
| 8/10/2008 | DRI | Jurrjens | Demoted to reserve roster | | | Before |
| 8/10/2008 | DRI | Miller | Demoted to reserve roster | | | Before |
| 8/10/2008 | DRI | Perez | Signed | | | Before |
| 8/10/2008 | DRI | Phillips | Signed | | | Before |
| 8/10/2008 | DRI | Prior | Released | | | Before |
| 8/10/2008 | DRI | Ray | Demoted to reserve roster | | | Before |
| 8/10/2008 | DRI | Tavarez | Released | | | Before |
| 8/10/2008 | DRI | Wood | Demoted to reserve roster | | | Before |
| 8/10/2008 | IRI | Lee | Promoted to active roster | | | Before |
| 8/10/2008 | IRI | Pierre | Demoted to reserve roster | | | Before |
| 8/10/2008 | IRI | Pierre | Promoted to active roster | | | Before |
| 8/10/2008 | IRI | Sexson | Demoted to reserve roster | | | Before |
| 8/10/2008 | IRI | Sosa | Demoted to reserve roster | | | Before |
| 8/10/2008 | IRI | Wang | Promoted to active roster | | | Before |
| 8/10/2008 | MAI | Bynum | Promoted to active roster | | | Before |
| 8/10/2008 | MAI | Donnelly | Demoted to reserve roster | | | Before |
| 8/10/2008 | PEA | Jimenez | Released | | | Before |
| 8/10/2008 | PEA | Salas | Signed | | | Before |
| 8/10/2008 | PEA | Salas | Demoted to reserve roster | | | Before |
| 8/10/2008 | PHO | Crisp | Promoted to active roster | | | Before |
| 8/10/2008 | PHO | Embree | Demoted to reserve roster | | | Before |
| 8/10/2008 | PHO | Embree | Promoted to active roster | | | Before |
| 8/10/2008 | PHO | Embree | Promoted to active roster | | | Before |
| 8/10/2008 | PHO | Fuentes | Demoted to reserve roster | | | Before |
| 8/10/2008 | PHO | Fuentes | Promoted to active roster | | | Before |
| 8/10/2008 | PHO | Gallardo | Promoted to active roster | | | Before |
| 8/10/2008 | PHO | Hamels | Demoted to reserve roster | | | Before |
| 8/10/2008 | PHO | Hardy | Demoted to reserve roster | | | Before |
| 8/10/2008 | PHO | Hermida | Demoted to reserve roster | | | Before |
| 8/10/2008 | PHO | Kent | Demoted to reserve roster | | | Before |
| 8/10/2008 | PHO | Keppinger | Promoted to active roster | | | Before |
| 8/10/2008 | PHO | Kubel | Demoted to reserve roster | | | Before |
| 8/10/2008 | PHO | Ludwick | Promoted to active roster | | | Before |
| 8/10/2008 | PHO | Taschner | Demoted to reserve roster | | | Before |
| 8/10/2008 | PHO | Taschner | Promoted to active roster | | | Before |
| 8/10/2008 | PHO | Ward | Demoted to reserve roster | | | Before |
| 8/10/2008 | PHO | Ward | Promoted to active roster | | | Before |
| 8/10/2008 | PIN | Feierabend | Promoted to active roster | | | Before |
| 8/10/2008 | PIN | Hawkins | Promoted to active roster | | | Before |
| 8/10/2008 | PIN | Qualls | Demoted to reserve roster | | | Before |
| 8/10/2008 | PIN | Thatcher | Demoted to reserve roster | | | Before |
| 8/10/2008 | SCO | Duckworth | Signed | | | Before |
| 8/10/2008 | SCO | Hairston | Demoted to reserve roster | | | Before |
| 8/10/2008 | SCO | Nippert | Released | | | Before |
| 8/10/2008 | SCO | Verlander | Demoted to reserve roster | | | Before |
| 8/12/2008 | B C | Montero | Promoted to active roster | | | Before |
| 8/12/2008 | SID | Flores | Demoted to reserve roster | | | Before |
| 8/14/2008 | PIN | Delcarmen | Promoted to active roster | | | Before |
| 8/14/2008 | PIN | Feierabend | Demoted to reserve roster | | | Before |
| 8/14/2008 | PIN | Gallagher | Demoted to reserve roster | | | Before |
| 8/14/2008 | PIN | Qualls | Promoted to active roster | | | Before |
| 8/16/2008 | B C | Bergmann | Demoted to reserve roster | | | Before |
| 8/16/2008 | B C | Floyd | Promoted to active roster | | | Before |
| 8/16/2008 | B C | Garza | Promoted to active roster | | | Before |
| 8/16/2008 | B C | Kuo | Demoted to reserve roster | | | Before |
| 8/16/2008 | B C | Pena | Demoted to reserve roster | | | Before |
| 8/16/2008 | DRI | Costa | Released | | | Before |
| 8/16/2008 | DRI | Tejeda | Signed | | | Before |
| 8/16/2008 | MAI | Downs | Promoted to active roster | | | Before |
| 8/16/2008 | MAI | Pence | Demoted to reserve roster | | | Before |
| 8/16/2008 | PHO | Cordero | Demoted to reserve roster | | | Before |
| 8/16/2008 | PHO | Cruz | Demoted to reserve roster | | | Before |
| 8/16/2008 | PHO | Dillon | Demoted to reserve roster | | | Before |
| 8/16/2008 | PHO | Gallardo | Demoted to reserve roster | | | Before |
| 8/16/2008 | PHO | Hamels | Promoted to active roster | | | Before |
| 8/16/2008 | PHO | Hardy | Promoted to active roster | | | Before |
| 8/16/2008 | PHO | Hart | Demoted to reserve roster | | | Before |
| 8/16/2008 | PHO | Hart | Promoted to active roster | | | Before |
| 8/16/2008 | PHO | Hermida | Promoted to active roster | | | Before |
| 8/16/2008 | PHO | Kent | Promoted to active roster | | | Before |
| 8/16/2008 | PHO | Keppinger | Demoted to reserve roster | | | Before |
| 8/16/2008 | PHO | Kubel | Promoted to active roster | | | Before |
| 8/16/2008 | PHO | Ludwick | Demoted to reserve roster | | | Before |
| 8/16/2008 | PHO | Pena | Demoted to reserve roster | | | Before |
| 8/16/2008 | PHO | Ward | Promoted to active roster | | | Before |
| 8/16/2008 | PHO | Wassermann | Promoted to active roster | | | Before |
| 8/16/2008 | SCO | Accardo | Demoted to reserve roster | | | Before |
| 8/16/2008 | SCO | McCarthy | Demoted to reserve roster | | | Before |
| 8/16/2008 | SCO | Proctor | Promoted to active roster | | | Before |
| 8/16/2008 | SCO | Verlander | Promoted to active roster | | | Before |
| 8/16/2008 | SID | Morales | Promoted to active roster | | | Before |
| 8/16/2008 | SID | Parra | Demoted to reserve roster | | | Before |
| 8/16/2008 | SKT | Brocail | Promoted to active roster | | | Before |
| 8/16/2008 | SKT | Buchholz | Promoted to active roster | | | Before |
| 8/16/2008 | SKT | Gonzalez | Demoted to reserve roster | | | Before |
| 8/16/2008 | SKT | Matsuzaka | Promoted to active roster | | | Before |
| 8/16/2008 | SKT | Reyes | Promoted to active roster | | | Before |
| 8/16/2008 | SKT | Sampson | Demoted to reserve roster | | | Before |
| 8/16/2008 | SKT | Schilling | Demoted to reserve roster | | | Before |
| 8/16/2008 | SKT | Towers | Demoted to reserve roster | | | Before |
| 8/16/2008 | SSX | Eveland | Demoted to reserve roster | | | Before |
| 8/16/2008 | SSX | Nolasco | Promoted to active roster | | | Before |
| 8/16/2008 | VIC | Matsui | Demoted to reserve roster | | | Before |
| 8/16/2008 | VIC | Morales | Demoted to reserve roster | | | Before |
| 8/16/2008 | VIC | Murton | Demoted to reserve roster | | | Before |
| 8/19/2008 | PIN | Cairo | Promoted to active roster | | | Before |
| 8/20/2008 | IRI | Slaten | Promoted to active roster | | | Before |
| 8/20/2008 | IRI | Wellemeyer | Demoted to reserve roster | | | Before |
| 8/20/2008 | PIN | Diaz | Promoted to active roster | | | Before |
| 8/21/2008 | MAI | Germano | Demoted to reserve roster | | | Before |
| 8/21/2008 | SCO | Clark | Promoted to active roster | | | Before |
| 8/23/2008 | IRI | Counsell | Promoted to active roster | | | Before |
| 8/23/2008 | IRI | Loaiza | Promoted to active roster | | | Before |
| 8/23/2008 | IRI | Maybin | Promoted to active roster | | | Before |
| 8/23/2008 | IRI | Quintero | Promoted to active roster | | | Before |
| 8/23/2008 | IRI | Sexson | Promoted to active roster | | | Before |
| 8/23/2008 | IRI | Sosa | Promoted to active roster | | | Before |
| 8/23/2008 | IRI | Thames | Promoted to active roster | | | Before |
| 8/23/2008 | IRI | Tsao | Promoted to active roster | | | Before |
| 8/23/2008 | IRI | Valverde | Demoted to reserve roster | | | Before |
| 8/23/2008 | IRI | Wang | Demoted to reserve roster | | | Before |
| 8/23/2008 | MAI | Abercrombie | Promoted to active roster | | | Before |
| 8/23/2008 | MAI | Shealy | Released | | | Before |
| 8/23/2008 | MAI | Shearn | Signed | | | Before |
| 8/23/2008 | PEA | Bullington | Demoted to reserve roster | | | Before |
| 8/23/2008 | PEA | Bullington | Promoted to active roster | | | Before |
| 8/23/2008 | PEA | De Aza | Demoted to reserve roster | | | Before |
| 8/23/2008 | PEA | De Aza | Promoted to active roster | | | Before |
| 8/23/2008 | PEA | Frandsen | Promoted to active roster | | | Before |
| 8/23/2008 | PEA | Grudzielanek | Demoted to reserve roster | | | Before |
| 8/23/2008 | PEA | Grudzielanek | Promoted to active roster | | | Before |
| 8/23/2008 | PEA | Littleton | Demoted to reserve roster | | | Before |
| 8/23/2008 | PEA | Salas | Promoted to active roster | | | Before |
| 8/23/2008 | PEA | Tata | Demoted to reserve roster | | | Before |
| 8/23/2008 | PEA | Tata | Promoted to active roster | | | Before |
| 8/23/2008 | PHO | Cordero | Promoted to active roster | | | Before |
| 8/23/2008 | PHO | Cruz | Promoted to active roster | | | Before |
| 8/23/2008 | PHO | Dillon | Promoted to active roster | | | Before |
| 8/23/2008 | PHO | Fuentes | Promoted to active roster | | | Before |
| 8/23/2008 | PHO | Gallardo | Promoted to active roster | | | Before |
| 8/23/2008 | PHO | Hart | Promoted to active roster | | | Before |
| 8/23/2008 | PHO | Keppinger | Promoted to active roster | | | Before |
| 8/23/2008 | PHO | Ludwick | Promoted to active roster | | | Before |
| 8/23/2008 | PHO | Pena | Promoted to active roster | | | Before |
| 8/23/2008 | PIN | Castro | Promoted to active roster | | | Before |
| 8/23/2008 | PIN | Feierabend | Promoted to active roster | | | Before |
| 8/23/2008 | PIN | Gallagher | Promoted to active roster | | | Before |
| 8/23/2008 | PIN | Hernandez,O | Demoted to reserve roster | | | Before |
| 8/23/2008 | PIN | Sheets | Promoted to active roster | | | Before |
| 8/23/2008 | PIN | Thatcher | Promoted to active roster | | | Before |
| 8/23/2008 | SCO | Accardo | Promoted to active roster | | | Before |
| 8/23/2008 | SCO | Blackburn | Promoted to active roster | | | Before |
| 8/23/2008 | SCO | Gonzalez,Ed | Promoted to active roster | | | Before |
| 8/23/2008 | SCO | Hairston | Promoted to active roster | | | Before |
| 8/23/2008 | SCO | McCarthy | Promoted to active roster | | | Before |
| 8/23/2008 | SCO | Perez,T | Promoted to active roster | | | Before |
| 8/23/2008 | SCO | Ruggiano | Promoted to active roster | | | Before |
| 8/23/2008 | SID | Buckner | Promoted to active roster | | | Before |
| 8/23/2008 | SID | Flores | Promoted to active roster | | | Before |
| 8/23/2008 | SID | Lewis | Promoted to active roster | | | Before |
| 8/23/2008 | SID | Parra | Promoted to active roster | | | Before |
| 8/23/2008 | SID | Snyder | Promoted to active roster | | | Before |
| 8/23/2008 | SKT | Blanco | Promoted to active roster | | | Before |
| 8/23/2008 | SKT | Davis | Promoted to active roster | | | Before |
| 8/23/2008 | SKT | Giles,M | Promoted to active roster | | | Before |
| 8/23/2008 | SKT | Gonzalez | Demoted to reserve roster | | | Before |
| 8/23/2008 | SKT | Gonzalez | Promoted to active roster | | | Before |
| 8/23/2008 | SKT | Mendoza | Promoted to active roster | | | Before |
| 8/23/2008 | SKT | Miles | Promoted to active roster | | | Before |
| 8/23/2008 | SKT | Rasner | Promoted to active roster | | | Before |
| 8/23/2008 | SKT | Sampson | Promoted to active roster | | | Before |
| 8/23/2008 | SKT | Schilling | Promoted to active roster | | | Before |
| 8/23/2008 | SKT | Towers | Promoted to active roster | | | Before |
| 8/27/2008 | B C | Burgos | Demoted to reserve roster | | | Before |
| 8/27/2008 | B C | Peralta | Promoted to active roster | | | Before |
| 8/28/2008 | B C | Bergmann | Demoted to reserve roster | | | Before |
| 8/28/2008 | B C | Bergmann | Promoted to active roster | | | Before |
| 8/28/2008 | B C | Dellucci | Promoted to active roster | | | Before |
| 8/28/2008 | B C | Kuo | Promoted to active roster | | | Before |
| 8/28/2008 | B C | Misch | Promoted to active roster | | | Before |
| 8/28/2008 | B C | Pena | Promoted to active roster | | | Before |
| 8/28/2008 | B C | Richar | Promoted to active roster | | | Before |
| 8/28/2008 | B C | Salazar | Promoted to active roster | | | Before |
| 8/28/2008 | B C | Sweeney | Promoted to active roster | | | Before |
| 8/28/2008 | DRI | Bonifacio | Released | | | Before |
| 8/28/2008 | DRI | Carpenter | Demoted to reserve roster | | | Before |
| 8/28/2008 | DRI | Fossum | Signed | | | Before |
| 8/28/2008 | DRI | Maxwell | Released | | | Before |
| 8/28/2008 | DRI | Quentin | Demoted to reserve roster | | | Before |
| 8/28/2008 | DRI | Wickman | Signed | | | Before |
| 8/28/2008 | IRI | Valverde | Promoted to active roster | | | Before |
| 8/28/2008 | IRI | Wang | Promoted to active roster | | | Before |
| 8/28/2008 | MAI | Pence | Promoted to active roster | | | Before |
| 8/28/2008 | MAI | Perez | Promoted to active roster | | | Before |
| 8/28/2008 | MAI | Schroder | Promoted to active roster | | | Before |
| 8/28/2008 | PEA | Bullington | Promoted to active roster | | | Before |
| 8/28/2008 | PEA | De Aza | Promoted to active roster | | | Before |
| 8/28/2008 | PEA | Ojeda | Promoted to active roster | | | Before |
| 8/28/2008 | PEA | Tata | Promoted to active roster | | | Before |
| 8/28/2008 | PIN | Blackley | Promoted to active roster | | | Before |
| 8/28/2008 | PIN | Hernandez,O | Promoted to active roster | | | Before |
| 8/28/2008 | PIN | Mulder | Promoted to active roster | | | Before |
| 8/28/2008 | PIN | Wakefield | Demoted to reserve roster | | | Before |
| 8/28/2008 | PIN | Young | Promoted to active roster | | | Before |
| 8/28/2008 | SCO | Ruggiano | Demoted to reserve roster | | | Before |
| 8/28/2008 | SID | Ayala | Demoted to reserve roster | | | Before |
| 8/28/2008 | SID | Bradford | Demoted to reserve roster | | | Before |
| 8/28/2008 | SID | Garko | Demoted to reserve roster | | | Before |
| 9/1/2008 | DRI | Bonifacio | Released | | | Before |
| 9/1/2008 | DRI | Fossum | Signed | | | Before |
| 9/1/2008 | DRI | Maxwell | Released | | | Before |
| 9/1/2008 | DRI | Wickman | Signed | | | Before |
| 9/1/2008 | MAI | Abercrombie | Released | | | Before |
| 9/1/2008 | MAI | Bynum | Released | | | Before |
| 9/1/2008 | MAI | Chacin | Released | | | Before |
| 9/1/2008 | MAI | Chavez | Signed | | | Before |
| 9/1/2008 | MAI | Gwynn | Signed | | | Before |
| 9/1/2008 | MAI | Johnson | Signed | | | Before |
| 9/1/2008 | SSX | Ausmus | Demoted to reserve roster | | | Before |
| 9/1/2008 | SSX | Ausmus | Promoted to active roster | | | Before |
| 9/1/2008 | SSX | Backe | Released | | | Before |
| 9/1/2008 | SSX | Belisle | Signed | | | Before |
| 9/1/2008 | SSX | Danks | Demoted to reserve roster | | | Before |
| 9/1/2008 | SSX | Koshansky | Promoted to active roster | | | Before |
| 9/1/2008 | SSX | Murphy | Demoted to reserve roster | | | Before |
| 9/1/2008 | SSX | Nolasco | Demoted to reserve roster | | | Before |
| 9/1/2008 | SSX | Thomas | Released | | | Before |
| 9/1/2008 | SSX | Youman | Signed | | | Before |
| 9/1/2008 | VIC | Anderson | Demoted to reserve roster | | | Before |
| 9/1/2008 | VIC | Cruz | Signed | | | Before |
| 9/1/2008 | VIC | Eyre | Signed | | | Before |
| 9/1/2008 | VIC | Hanrahan | Demoted to reserve roster | | | Before |
| 9/1/2008 | VIC | Hill,K | Signed | | | Before |
| 9/1/2008 | VIC | Lowry | Demoted to reserve roster | | | Before |
| 9/1/2008 | VIC | Maroth | Signed | | | Before |
| 9/1/2008 | VIC | Mastny | Released | | | Before |
| 9/1/2008 | VIC | Osoria | Released | | | Before |
| 9/1/2008 | VIC | Rabelo | Released | | | Before |
| 9/1/2008 | VIC | Rabelo | Demoted to reserve roster | | | Before |
| 9/1/2008 | VIC | Sanders | Released | | | Before |
| 9/2/2008 | B C | Bergmann | Promoted to active roster | | | Before |
| 9/2/2008 | DRI | Fields | Promoted to active roster | | | Before |
| 9/2/2008 | MAI | Downs | Demoted to reserve roster | | | Before |
| 9/2/2008 | MAI | Dye | Demoted to reserve roster | | | Before |
| 9/2/2008 | MAI | Greinke | Demoted to reserve roster | | | Before |
| 9/2/2008 | MAI | Perez | Demoted to reserve roster | | | Before |
| 9/2/2008 | MAI | Schroder | Demoted to reserve roster | | | Before |
| 9/2/2008 | MAI | Spilborghs | Demoted to reserve roster | | | Before |
| 9/2/2008 | PIN | Ankiel | Demoted to reserve roster | | | Before |
| 9/2/2008 | PIN | Looper | Demoted to reserve roster | | | Before |
| 9/2/2008 | PIN | Wakefield | Promoted to active roster | | | Before |
| 9/2/2008 | PIN | Young | Demoted to reserve roster | | | Before |
| 9/6/2008 | MAI | Lieberthal | Demoted to reserve roster | | | Before |
| 9/6/2008 | MAI | Melhuse | Demoted to reserve roster | | | Before |
| 9/6/2008 | MAI | Pence | Demoted to reserve roster | | | Before |
| 9/6/2008 | MAI | Willits | Demoted to reserve roster | | | Before |
| 9/8/2008 | B C | Iwamura | Demoted to reserve roster | | | Before |
| 9/8/2008 | DRI | Aybar | Demoted to reserve roster | | | Before |
| 9/8/2008 | DRI | Millar | Demoted to reserve roster | | | Before |
| 9/8/2008 | DRI | Pedroia | Demoted to reserve roster | | | Before |
| 9/8/2008 | DRI | Pedroia | Promoted to active roster | | | Before |
| 9/8/2008 | DRI | Quentin | Promoted to active roster | | | Before |
| 9/8/2008 | MAI | Lieberthal | Released | | | Before |
| 9/8/2008 | MAI | Melhuse | Released | | | Before |
| 9/8/2008 | MAI | Miller | Signed | | | Before |
| 9/8/2008 | MAI | Santos | Signed | | | Before |
| 9/8/2008 | PHO | Hart | Demoted to reserve roster | | | Before |
| 9/8/2008 | PIN | Ankiel | Promoted to active roster | | | Before |
| 9/8/2008 | PIN | Blackley | Demoted to reserve roster | | | Before |
| 9/8/2008 | PIN | Dempster | Demoted to reserve roster | | | Before |
| 9/8/2008 | PIN | Feierabend | Demoted to reserve roster | | | Before |
| 9/8/2008 | PIN | Feierabend | Promoted to active roster | | | Before |
| 9/8/2008 | PIN | Gallagher | Demoted to reserve roster | | | Before |
| 9/8/2008 | PIN | Looper | Promoted to active roster | | | Before |
| 9/8/2008 | PIN | Mulder | Demoted to reserve roster | | | Before |
| 9/8/2008 | SID | Ayala | Promoted to active roster | | | Before |
| 9/8/2008 | SID | Bradford | Promoted to active roster | | | Before |
| 9/8/2008 | SID | Escobar | Demoted to reserve roster | | | Before |
| 9/8/2008 | SID | Figgins | Promoted to active roster | | | Before |
| 9/8/2008 | SID | Lewis | Promoted to active roster | | | Before |
| 9/8/2008 | SID | Patton | Promoted to active roster | | | Before |
| 9/8/2008 | SKT | Gonzalez | Promoted to active roster | | | Before |
| 9/9/2008 | SID | Buckner | Demoted to reserve roster | | | Before |
| 9/9/2008 | SID | Linebrink | Demoted to reserve roster | | | Before |
| 9/11/2008 | PIN | Thatcher | Demoted to reserve roster | | | Before |
| 9/12/2008 | B C | Bergmann | Demoted to reserve roster | | | Before |
| 9/12/2008 | B C | Tracy | Demoted to reserve roster | | | Before |
| 9/12/2008 | B C | Volquez | Demoted to reserve roster | | | Before |
| 9/12/2008 | IRI | Valverde | Demoted to reserve roster | | | Before |
| 9/12/2008 | MAI | Alfonzo | Released | | | Before |
| 9/12/2008 | MAI | Durbin | Signed | | | Before |
| 9/12/2008 | SID | Ayala | Demoted to reserve roster | | | Before |
| 9/12/2008 | SID | Beltre | Demoted to reserve roster | | | Before |
| 9/12/2008 | SID | Bradford | Demoted to reserve roster | | | Before |
| 9/12/2008 | SID | Church | Demoted to reserve roster | | | Before |
| 9/12/2008 | SID | Figgins | Demoted to reserve roster | | | Before |
| 9/12/2008 | SID | Lewis | Demoted to reserve roster | | | Before |
| 9/13/2008 | B C | Garza | Demoted to reserve roster | | | Before |
| 9/13/2008 | B C | Kuo | Demoted to reserve roster | | | Before |
| 9/13/2008 | B C | LaRoche | Demoted to reserve roster | | | Before |
| 9/13/2008 | B C | Loewen | Promoted to active roster | | | Before |
| 9/13/2008 | B C | Oswalt | Demoted to reserve roster | | | Before |
| 9/13/2008 | IRI | Crain | Promoted to active roster | | | Before |
| 9/13/2008 | MAI | Downs | Promoted to active roster | | | Before |
| 9/13/2008 | MAI | Dye | Promoted to active roster | | | Before |
| 9/13/2008 | MAI | Pence | Promoted to active roster | | | Before |
| 9/13/2008 | MAI | Perez | Promoted to active roster | | | Before |
| 9/13/2008 | MAI | Shearn | Demoted to reserve roster | | | Before |
| 9/13/2008 | MAI | Willits | Promoted to active roster | | | Before |
| 9/13/2008 | PEA | Halladay | Demoted to reserve roster | | | Before |
| 9/13/2008 | PEA | Tallet | Demoted to reserve roster | | | Before |
| 9/13/2008 | PHO | Dillon | Demoted to reserve roster | | | Before |
| 9/13/2008 | PIN | Blackley | Promoted to active roster | | | Before |
| 9/13/2008 | PIN | Gallagher | Promoted to active roster | | | Before |
| 9/13/2008 | PIN | Mulder | Promoted to active roster | | | Before |
| 9/13/2008 | PIN | Young | Promoted to active roster | | | Before |
| 9/13/2008 | SCO | Ruggiano | Promoted to active roster | | | Before |
| 9/13/2008 | SKT | Gonzalez | Demoted to reserve roster | | | Before |
| 9/13/2008 | VIC | Bannister | Demoted to reserve roster | | | Before |
| 9/13/2008 | VIC | Bennett | Signed | | | Before |
| 9/13/2008 | VIC | Buehrle | Demoted to reserve roster | | | Before |
| 9/13/2008 | VIC | Fox | Released | | | Before |
| 9/13/2008 | VIC | Freel | Demoted to reserve roster | | | Before |
| 9/13/2008 | VIC | Freel | Promoted to active roster | | | Before |
| 9/13/2008 | VIC | Hennessey | Demoted to reserve roster | | | Before |
| 9/13/2008 | VIC | Howry | Released | | | Before |
| 9/13/2008 | VIC | Thomson | Signed | | | Before |
| 9/13/2008 | VIC | Votto | Demoted to reserve roster | | | Before |
| 9/16/2008 | MAI | Belliard | Demoted to reserve roster | | | Before |
| 9/16/2008 | MAI | Miller | Demoted to reserve roster | | | Before |
| 9/18/2008 | MAI | DeRosa | Demoted to reserve roster | | | Before |
| 9/18/2008 | MAI | Dohmann | Released | | | Before |
| 9/18/2008 | MAI | Donnelly | Released | | | Before |
| 9/18/2008 | MAI | Downs | Demoted to reserve roster | | | Before |
| 9/18/2008 | MAI | Dye | Demoted to reserve roster | | | Before |
| 9/18/2008 | MAI | Dye | Promoted to active roster | | | Before |
| 9/18/2008 | MAI | Dye | Demoted to reserve roster | | | Before |
| 9/18/2008 | MAI | Fogg | Demoted to reserve roster | | | Before |
| 9/18/2008 | MAI | Galarraga | Signed | | | Before |
| 9/18/2008 | MAI | Linden | Signed | | | Before |
| 9/18/2008 | MAI | Miller | Released | | | Before |
| 9/18/2008 | MAI | Nieves | Signed | | | Before |
| 9/18/2008 | MAI | Perez | Demoted to reserve roster | | | Before |
| 9/18/2008 | MAI | Podsednik | Signed | | | Before |
| 9/18/2008 | MAI | Shearn | Released | | | Before |
| 9/18/2008 | PEA | Happ | Promoted to active roster | | | Before |
| 9/18/2008 | PEA | Hirsh | Demoted to reserve roster | | | Before |
| 9/18/2008 | PEA | Muniz | Promoted to active roster | | | Before |
| 9/18/2008 | PEA | Vazquez | Demoted to reserve roster | | | Before |
| 9/18/2008 | PHO | Cordero | Demoted to reserve roster | | | Before |
| 9/18/2008 | PHO | Rodney | Demoted to reserve roster | | | Before |
| 9/18/2008 | PIN | Hawkins | Demoted to reserve roster | | | Before |
| 9/18/2008 | SCO | Accardo | Demoted to reserve roster | | | Before |
| 9/18/2008 | SCO | Blackburn | Demoted to reserve roster | | | Before |
| 9/18/2008 | SCO | Casilla | Demoted to reserve roster | | | Before |
| 9/18/2008 | SCO | Perez,T | Demoted to reserve roster | | | Before |
| 9/18/2008 | SCO | Ruggiano | Demoted to reserve roster | | | Before |
| 9/18/2008 | SID | Buckner | Released | | | Before |
| 9/18/2008 | SID | Buckner | Released | | | Before |
| 9/18/2008 | SID | Garcia,F | Promoted to active roster | | | Before |
| 9/18/2008 | SID | Mateo | Signed | | | Before |
| 9/18/2008 | SID | Mateo | Signed | | | Before |
| 9/18/2008 | SID | Patton | Demoted to reserve roster | | | Before |
| 9/18/2008 | SKT | Gonzalez | Promoted to active roster | | | Before |
| 9/22/2008 | B C | Burgos | Promoted to active roster | | | Before |
| 9/22/2008 | B C | Iwamura | Promoted to active roster | | | Before |
| 9/22/2008 | B C | Kuo | Promoted to active roster | | | Before |
| 9/22/2008 | B C | LaRoche | Promoted to active roster | | | Before |
| 9/22/2008 | B C | Oswalt | Promoted to active roster | | | Before |
| 9/22/2008 | B C | Tracy | Promoted to active roster | | | Before |
| 9/24/2008 | IRI | Crain | Demoted to reserve roster | | | Before |
| 9/24/2008 | IRI | Loaiza | Demoted to reserve roster | | | Before |
| 9/24/2008 | IRI | Maybin | Demoted to reserve roster | | | Before |
| 9/24/2008 | IRI | Pierre | Demoted to reserve roster | | | Before |
| 9/24/2008 | IRI | Quintero | Demoted to reserve roster | | | Before |
| 9/24/2008 | IRI | Sexson | Demoted to reserve roster | | | Before |
| 9/24/2008 | IRI | Slaten | Demoted to reserve roster | | | Before |
| 9/24/2008 | IRI | Sosa | Demoted to reserve roster | | | Before |
| 9/24/2008 | IRI | Tsao | Demoted to reserve roster | | | Before |
| 9/24/2008 | IRI | Valverde | Promoted to active roster | | | Before |
| 9/24/2008 | PHO | Crisp | Demoted to reserve roster | | | Before |
| 9/24/2008 | PHO | Gorzelanny | Demoted to reserve roster | | | Before |
| 9/24/2008 | PHO | Mackowiak | Demoted to reserve roster | | | Before |
| 9/24/2008 | PHO | Vargas | Demoted to reserve roster | | | Before |
| 9/24/2008 | PHO | Ward | Demoted to reserve roster | | | Before |
| 9/24/2008 | SCO | Accardo | Promoted to active roster | | | Before |
| 9/24/2008 | SCO | Casilla | Promoted to active roster | | | Before |
| 9/24/2008 | SCO | Clark | Demoted to reserve roster | | | Before |
| 9/24/2008 | SCO | Drew | Demoted to reserve roster | | | Before |
| 9/24/2008 | SCO | Duckworth | Demoted to reserve roster | | | Before |
| 9/24/2008 | SCO | Gonzalez,Ed | Demoted to reserve roster | | | Before |
| 9/24/2008 | SCO | Hairston | Demoted to reserve roster | | | Before |
| 9/24/2008 | SCO | Perez,T | Promoted to active roster | | | Before |
| 9/24/2008 | SCO | Proctor | Demoted to reserve roster | | | Before |
| 9/24/2008 | SCO | Proctor | Promoted to active roster | | | Before |
| 9/24/2008 | SCO | Washburn | Demoted to reserve roster | | | Before |
| 9/27/2008 | B C | Floyd | Promoted to active roster | | | Before |
| 9/29/2008 | B C | Bergmann | Promoted to active roster | | | Before |
| 9/29/2008 | B C | Dellucci | Demoted to reserve roster | | | Before |
| 9/29/2008 | B C | Floyd | Demoted to reserve roster | | | Before |
| 9/29/2008 | B C | Garza | Promoted to active roster | | | Before |
| 9/29/2008 | B C | Kuo | Demoted to reserve roster | | | Before |
| 9/29/2008 | B C | Loewen | Demoted to reserve roster | | | Before |
| 9/29/2008 | B C | Murphy | Demoted to reserve roster | | | Before |
| 9/29/2008 | B C | Murphy | Promoted to active roster | | | Before |
| 9/29/2008 | B C | Pena | Demoted to reserve roster | | | Before |
| 9/29/2008 | B C | Richar | Demoted to reserve roster | | | Before |
| 9/29/2008 | B C | Salazar | Demoted to reserve roster | | | Before |
| 9/29/2008 | B C | Sweeney | Demoted to reserve roster | | | Before |
| 9/29/2008 | B C | VandenHurk | Demoted to reserve roster | | | Before |
| 9/29/2008 | B C | Volquez | Demoted to reserve roster | | | Before |
| 9/29/2008 | B C | Volquez | Promoted to active roster | | | Before |
| 10/4/2008 | IRI | Wellemeyer | Promoted to active roster | | | Before |
| 10/14/2008 | IRI | Wellemeyer | Demoted to reserve roster | | | Before |