League injury log -- National
Regular season -- as of 10/24/2021
| Injuries |
| Date | # | Team | Player | Cause | Dur |
| 4/2/2021 | | DUT | Hand | General | 10 |
| 4/3/2021 | | STO | Solano | General | 2 |
| 4/3/2021 | | SYN | Gallo | General | 8 |
| 4/4/2021 | | BRO | Segura | General | 6 |
| 4/4/2021 | | COM | Snell | General | 16 |
| 4/5/2021 | | BRO | Marte,S | General | 1 |
| 4/5/2021 | | CLE | Machado | General | 1 |
| 4/5/2021 | | FOR | Perez,Mi | Collision in field | 16 |
| 4/6/2021 | | FOR | Ponce | General | 11 |
| 4/7/2021 | | SLG | Frazier,A | Hit by pitch | 6 |
| 4/7/2021 | | FOR | Dickerson,A | General | 5 |
| 4/8/2021 | | SYN | Adell | General | 3 |
| 4/9/2021 | | DEM | Crawford,JP | General | 1 |
| 4/10/2021 | | DRI | Madrigal | Hit by pitch | 21 |
| 4/10/2021 | | DEM | Lindblom | General | 6 |
| 4/10/2021 | | DEM | Shaw,T | General | 15 |
| 4/10/2021 | | DUT | Vogt | General | 4 |
| 4/10/2021 | | COM | Franco | General | 1 |
| 4/11/2021 | | STO | Rodriguez,R | General | 9 |
| 4/12/2021 | | DUT | Marte,K | General | 29 |
| 4/13/2021 | | BRO | Lowe,B | Hit by pitch | 12 |
| 4/13/2021 | | DUT | Adames | General | 8 |
| 4/14/2021 | | BRO | Buehler | General | 21 |
| 4/18/2021 | | RLF | Cordero,F | General | 19 |
| 4/20/2021 | | CLE | Kemp,T | Hit by pitch | 31 |
| 4/20/2021 | | STO | Gonzalez,V | General | 4 |
| 4/20/2021 | | STO | Realmuto | Hit by pitch | 1 |
| 4/20/2021 | | SLG | Kelly,C | General | 4 |
| 4/21/2021 | | DUT | Peralta,D | General | 1 |
| 4/22/2021 | | FOR | Hernandez,Ce | General | 1 |
| 4/23/2021 | | RLF | Kim | General | 26 |
| 4/25/2021 | | COM | Leon | General | 1 |
| 4/26/2021 | | DEM | Galvis | General | 3 |
| 4/26/2021 | | DEM | Vogelbach | Hit by pitch | 26 |
| 4/28/2021 | | DRI | Cabrera,M | General | 1 |
| 4/28/2021 | | COM | Arozarena | Hit by pitch | 1 |
| 4/29/2021 | | DRI | Brewer | General | 16 |
| 4/30/2021 | | BRO | Cano | General | 6 |
| 5/1/2021 | | DUT | Straw | General | 1 |
| 5/3/2021 | | COM | Mayers | General | 1 |
| 5/3/2021 | | STO | Peraza | General | 7 |
| 5/5/2021 | | COM | Arozarena | Hit by pitch | 21 |
| 5/5/2021 | | BRO | Segura | General | 12 |
| 5/5/2021 | | DRI | Murphy,JR | General | 4 |
| 5/5/2021 | | DEM | Burnes | General | 11 |
| 5/5/2021 | | DUT | Paxton | Brawl | 20 |
| 5/5/2021 | | STO | Simmons | Hit by pitch | 19 |
| 5/5/2021 | | STO | Solano | Hit by pitch | 17 |
| 5/6/2021 | | RLF | Roark | General | 16 |
| 5/6/2021 | | FOR | Clarke | General | 11 |
| 5/9/2021 | | RLF | Hernandez,T | General | 1 |
| 5/10/2021 | | CLE | Machado | General | 1 |
| 5/11/2021 | | SLG | Thomas | General | 6 |
| 5/11/2021 | | COM | Smith,Do | General | 1 |
| 5/11/2021 | | DUT | Chapman,M | General | 1 |
| 5/12/2021 | | DRI | Machin | General | 14 |
| 5/14/2021 | | DUT | Rogers,Ta | General | 1 |
| 5/15/2021 | | FOR | Garcia,LV | General | 1 |
| 5/16/2021 | | RLF | Freeman,F | General | 1 |
| 5/16/2021 | | STO | Bradley,A | General | 18 |
| 5/17/2021 | | DRI | Cabrera,M | General | 1 |
| 5/17/2021 | | SLG | Oviedo | General | 1 |
| 5/18/2021 | | FOR | Clippard | General | 2 |
| 5/19/2021 | | DRI | Machin | General | 7 |
| 5/19/2021 | | SYN | Holland,D | General | 1 |
| 5/20/2021 | | DRI | Mahle | Brawl | 3 |
| 5/21/2021 | | DRI | Cabrera,M | General | 1 |
| 5/21/2021 | | DRI | Riley | General | 3 |
| 5/21/2021 | | FOR | Chisholm | General | 1 |
| 5/22/2021 | | DRI | Olivares | General | 3 |
| 5/22/2021 | | COM | Franco | General | 1 |
| 5/23/2021 | | FOR | Garcia,LV | General | 3 |
| 5/24/2021 | | SYN | Lopez,J | General | 2 |
| 5/24/2021 | | FOR | Seager,K | General | 1 |
| 5/25/2021 | | COM | Arozarena | General | 1 |
| 5/27/2021 | | STO | Simmons | General | 12 |
| 5/29/2021 | | SYN | Wright | General | 1 |
| 5/30/2021 | | CLE | La Stella | General | 1 |
| 5/30/2021 | | SMS | Gurriel.L | Collision on bases | 4 |
| 5/31/2021 | | DRI | Matz | General | 1 |
| 5/31/2021 | | RLF | Freeman,F | General | 1 |
| 6/1/2021 | | DRI | Cabrera,M | General | 1 |
| 6/1/2021 | | SLG | Ervin | General | 2 |
| 6/3/2021 | | BRO | Soto,J | General | 3 |
| 6/4/2021 | | DRI | Cabrera,M | General | 1 |
| 6/4/2021 | | STO | Realmuto | General | 1 |
| 6/5/2021 | | DUT | Lorenzen | General | 1 |
| 6/5/2021 | | CLE | Wendle | General | 3 |
| 6/6/2021 | | FOR | Goldschmidt | General | 1 |
| 6/6/2021 | | DRI | Paredes,I | General | 1 |
| 6/7/2021 | | BRO | Marte,S | General | 1 |
| 6/10/2021 | | DRI | Anderson,C | General | 6 |
| 6/10/2021 | | RLF | Freeman,F | General | 1 |
| 6/11/2021 | | DRI | Alexander,T | General | 13 |
| 6/11/2021 | | STO | Alfaro | Hit by pitch | 33 |
| 6/12/2021 | | CLE | Berti | General | 1 |
| 6/13/2021 | | SYN | Kepler | General | 1 |
| 6/15/2021 | | COM | Biggio | General | 1 |
| 6/16/2021 | | RLF | Gregorius | General | 1 |
| 6/17/2021 | | COM | Franco | General | 1 |
| 6/17/2021 | | SYN | Kepler | General | 6 |
| 6/17/2021 | | RLF | Gregorius | General | 1 |
| 6/18/2021 | | DUT | Casali | Hit by pitch | 1 |
| 6/18/2021 | | COM | Hudson,Dak | General | 31 |
| 6/18/2021 | | SYN | Gallo | Hit by pitch | 9 |
| 6/18/2021 | | SYN | Robles,V | Hit by pitch | 23 |
| 6/18/2021 | | FOR | Garneau | General | 8 |
| 6/19/2021 | | DUT | Kingery | General | 1 |
| 6/19/2021 | | SMS | Alonso | General | 3 |
| 6/20/2021 | | COM | Melancon | General | 8 |
| 6/20/2021 | | SYN | Senzel | General | 14 |
| 6/20/2021 | | RLF | Kim | General | 11 |
| 6/24/2021 | | RLF | Gregorius | General | 1 |
| 6/24/2021 | | RLF | Hill,R | General | 46 |
| 6/27/2021 | | SLG | Benjamin | General | 15 |
| 6/28/2021 | | DRI | Cabrera,M | General | 1 |
| 6/29/2021 | | DEM | Lindblom | General | 15 |
| 6/30/2021 | | DUT | Devers | General | 7 |
| 7/1/2021 | | DUT | Lorenzen | General | 17 |
| 7/1/2021 | | SMS | Anderson,S | General | 1 |
| 7/1/2021 | | SMS | DeShields | General | 9 |
| 7/1/2021 | | STO | Rosario,E | General | 8 |
| 7/1/2021 | | FOR | Dickerson,A | General | 1 |
| 7/2/2021 | | SYN | Flaherty | General | 16 |
| 7/2/2021 | | BRO | Peralta,W | General | 1 |
| 7/2/2021 | | RLF | Duvall | General | 1 |
| 7/6/2021 | | RLF | Castro,M | General | 2 |
| 7/6/2021 | | DEM | Baez,J | General | 1 |
| 7/6/2021 | | SLG | Pujols | General | 1 |
| 7/7/2021 | | STO | Grossman | Hit by pitch | 3 |
| 7/8/2021 | | DRI | Arroyo | General | 9 |
| 7/8/2021 | | DEM | White,Ev | General | 3 |
| 7/9/2021 | | RLF | Ruiz,R | General | 10 |
| 7/9/2021 | | SLG | Frazier,A | General | 5 |
| 7/9/2021 | | SLG | Lamb | General | 5 |
| 7/10/2021 | | DEM | Varsho | General | 3 |
| 7/10/2021 | | STO | Realmuto | Hit by pitch | 12 |
| 7/10/2021 | | STO | Sheffield | General | 16 |
| 7/10/2021 | | COM | Hicks | Brawl | 17 |
| 7/11/2021 | | DUT | Adames | General | 1 |
| 7/13/2021 | | DUT | Paxton | General | 1 |
| 7/13/2021 | | FOR | Escobar | General | 6 |
| 7/13/2021 | | FOR | Lopez,Y | General | 3 |
| 7/14/2021 | | DRI | Knebel | General | 1 |
| 7/15/2021 | | COM | Luzardo | General | 6 |
| 7/15/2021 | | FOR | Castellani | General | 6 |
| 7/16/2021 | | SYN | Allard | General | 11 |
| 7/16/2021 | | RLF | Freeman,F | General | 1 |
| 7/17/2021 | | FOR | Greiner | General | 2 |
| 7/18/2021 | | BRO | Rios,E | Hit by pitch | 1 |
| 7/18/2021 | | CLE | Wendle | General | 16 |
| 7/18/2021 | | COM | Margevicius | General | 4 |
| 7/20/2021 | | STO | Musgrove | General | 1 |
| 7/20/2021 | | STO | Rodriguez,R | General | 1 |
| 7/20/2021 | | BRO | Lowe,B | General | 1 |
| 7/23/2021 | | STO | Solano | General | 1 |
| 7/24/2021 | | DUT | Kemp,M | General | 3 |
| 7/25/2021 | | DRI | Milone | General | 26 |
| 7/25/2021 | | DEM | Gonzalez,M | General | 2 |
| 7/27/2021 | | SYN | Tatis | General | 1 |
| 7/27/2021 | | RLF | Hernandez,T | General | 6 |
| 7/28/2021 | | DEM | Beeks | Brawl | 35 |
| 7/28/2021 | | DEM | Fletcher,D | General | 8 |
| 7/28/2021 | | RLF | Hoerner | Brawl | 11 |
| 7/28/2021 | | RLF | Raley | General | 11 |
| 7/29/2021 | | STO | Trout | General | 4 |
| 7/30/2021 | | FOR | Brantley | General | 15 |
| 7/31/2021 | | FOR | Clarke | General | 5 |
| 7/31/2021 | | FOR | Rogers,Tr | General | 1 |
| 8/2/2021 | | DEM | Varsho | General | 6 |
| 8/5/2021 | | RLF | Ruiz,R | General | 1 |
| 8/5/2021 | | SYN | Kepler | General | 1 |
| 8/6/2021 | | SLG | Mayfield | General | 3 |
| 8/6/2021 | | CLE | Kemp,T | Hit by pitch | 19 |
| 8/6/2021 | | RLF | Wong | General | 1 |
| 8/7/2021 | | COM | Turner,T | General | 1 |
| 8/8/2021 | | RLF | Freeman,F | General | 1 |
| 8/10/2021 | | SLG | Richards,T | General | 14 |
| 8/11/2021 | | SYN | McMahon | General | 4 |
| 8/11/2021 | | SLG | White,El | General | 6 |
| 8/12/2021 | | SMS | Narvaez | General | 6 |
| 8/12/2021 | | SMS | Yardley | General | 2 |
| 8/12/2021 | | RLF | Mize | General | 15 |
| 8/14/2021 | | CLE | Selman | General | 1 |
| 8/15/2021 | | COM | Moran,C | General | 4 |
| 8/16/2021 | | FOR | Hernandez,Ce | General | 1 |
| 8/17/2021 | | COM | Tapia,R | General | 3 |
| 8/19/2021 | | FOR | Goldschmidt | General | 1 |
| 8/19/2021 | | CLE | Williams,D | General | 4 |
| 8/20/2021 | | DRI | Mahle | General | 6 |
| 8/21/2021 | | CLE | Keuchel | General | 6 |
| 8/23/2021 | | DEM | Varsho | Brawl | 35 |
| 8/23/2021 | | DEM | Wallach | Brawl | 30 |
| 8/23/2021 | | DUT | Hand | Brawl | 35 |
| 8/24/2021 | | STO | Peraza | General | 14 |
| 8/24/2021 | | SYN | Wright | General | 6 |
| 8/26/2021 | | STO | Osuna,J | General | 1 |
| 8/26/2021 | | DEM | Montgomery,J | General | 11 |
| 8/26/2021 | | SLG | Pence | General | 4 |
| 8/27/2021 | | BRO | Molina | Collision in field | 1 |
| 8/27/2021 | | SYN | Skubal | General | 1 |
| 8/27/2021 | | COM | Turner,T | General | 1 |
| 8/28/2021 | | DRI | Matz | General | 1 |
| 8/29/2021 | | DRI | Riley | General | 2 |
| 8/29/2021 | | SYN | McMahon | General | 18 |
| 8/30/2021 | | DEM | Gonzalez,M | Hit by pitch | 20 |
| 8/30/2021 | | DUT | Adames | General | 3 |
| 8/30/2021 | | SYN | Alcantara,Sa | General | 21 |
| 8/31/2021 | | STO | Acuna | General | 3 |
| 9/1/2021 | | DUT | Rogers,Ta | General | 1 |
| 9/3/2021 | | DEM | Crawford,JP | General | 2 |
| 9/5/2021 | | DRI | Riley | General | 1 |
| 9/5/2021 | | RLF | Hill,R | General | 1 |
| 9/6/2021 | | COM | Moran,C | General | 19 |
| 9/8/2021 | | RLF | Webb,T | General | 1 |
| 9/9/2021 | | DRI | Holt | General | 14 |
| 9/10/2021 | | DRI | Rea | General | 19 |
| 9/11/2021 | | DRI | Butera | General | 1 |
| 9/12/2021 | | DRI | Perez,Mi | General | 1 |
| 9/12/2021 | | SLG | White,El | General | 1 |
| 9/15/2021 | | COM | Leon | General | 1 |
| 9/16/2021 | | BRO | Buehler | General | 6 |
| 9/16/2021 | | DUT | Straw | General | 4 |
| 9/16/2021 | | RLF | Freeman,F | General | 1 |
| 9/17/2021 | | BRO | Tepera | General | 18 |
| 9/17/2021 | | BRO | Verlander | General | 36 |
| 9/17/2021 | | SLG | LeBlanc | General | 46 |
| 9/18/2021 | | SMS | Chirinos,R | Brawl | 21 |
| 9/19/2021 | | SLG | Bruce | General | 10 |
| 9/19/2021 | | SLG | Martinez,C | General | 41 |
| 9/22/2021 | | RLF | Gregorius | General | 1 |
| 9/29/2021 | | RLF | Bundy | General | 1 |
| 10/1/2021 | | RLF | Winker | General | 1 |
| 10/5/2021 | | RLF | Bumgarner | General | 1 |
| 10/8/2021 | | STO | Correa | General | 5 |