| Primary | ||||||||||||
| Date | # | Opp | Score | Inn | Starter | T | W/L | Save | Versus | T | ||
| 4/1/2021 | @ | DRI | W | 2-1 | deGrom | R | Williams,D | Britton | Mahle | R | ||
| 4/2/2021 | @ | DRI | W | 14-1 | Civale | R | Harris | Milone | L | |||
| 4/3/2021 | @ | DRI | W | 3-2 | Keuchel | L | Keuchel | Britton | Mazza | R | ||
| 4/4/2021 | @ | DRI | W | 15-2 | May,D | R | May,D | Matz | L | |||
| 4/5/2021 | @ | DRI | W | 13-7 | Minor | L | Crichton | Williams,D | Nova | R | ||
| 4/6/2021 | @ | SLG | W | 4-3 | deGrom | R | deGrom | Britton | Weaver | R | ||
| 4/7/2021 | @ | SLG | W | 9-4 | 10 | Civale | R | Britton | Cobb | R | ||
| 4/8/2021 | @ | SLG | W | 5-2 | Keuchel | L | Keuchel | Britton | Ponce de Leon | R | ||
| 4/9/2021 | @ | SLG | L | 6-7 | May,D | R | Selman | Smyly | L | |||
| 4/10/2021 | @ | SLG | W | 1-0 | Minor | L | Minor | Britton | Keller,M | R | ||
| 4/11/2021 | STO | W | 11-6 | deGrom | R | deGrom | Lynn | R | ||||
| 4/12/2021 | STO | L | 2-4 | Civale | R | Civale | Wheeler | R | ||||
| 4/13/2021 | STO | W | 14-0 | Keuchel | L | Keuchel | Urias,J | L | ||||
| 4/14/2021 | STO | L | 7-10 | May,D | R | May,D | McKenzie | R | ||||
| 4/15/2021 | STO | W | 8-5 | Minor | L | Minor | Crichton | Musgrove | R | |||
| 4/17/2021 | DRI | W | 6-1 | deGrom | R | deGrom | Mahle | R | ||||
| 4/18/2021 | DRI | W | 15-5 | Civale | R | Civale | Matz | L | ||||
| 4/19/2021 | DRI | W | 8-0 | Keuchel | L | Keuchel | Wacha | R | ||||
| 4/20/2021 | DRI | W | 8-2 | Minor | L | Minor | Milone | L | ||||
| 4/21/2021 | DRI | L | 4-9 | May,D | R | May,D | Nova | R | ||||
| 4/22/2021 | @ | STO | W | 7-0 | deGrom | R | deGrom | Lynn | R | |||
| 4/23/2021 | @ | STO | W | 17-6 | Civale | R | McGee | Crichton | Urias,J | L | ||
| 4/24/2021 | @ | STO | W | 4-1 | Keuchel | L | Keuchel | Wheeler | R | |||
| 4/25/2021 | @ | STO | W | 5-1 | Minor | L | Minor | McKenzie | R | |||
| 4/26/2021 | @ | STO | L | 0-8 | May,D | R | May,D | Musgrove | R | |||
| 4/27/2021 | SLG | W | 8-1 | deGrom | R | deGrom | Weaver | R | ||||
| 4/28/2021 | SLG | W | 3-2 | Civale | R | Civale | Williams,D | Cobb | R | |||
| 4/29/2021 | SLG | W | 9-2 | Keuchel | L | Keuchel | Ponce de Leon | R | ||||
| 4/30/2021 | SLG | W | 7-5 | Minor | L | Minor | Britton | Oviedo | R | |||
| 5/1/2021 | SLG | W | 10-4 | May,D | R | May,D | Keller,M | R | ||||
| 5/3/2021 | @ | SYN | W | 12-4 | Civale | R | Civale | Sanchez,An | R | |||
| 5/4/2021 | @ | SYN | W | 15-1 | deGrom | R | deGrom | Skubal | L | |||
| 5/5/2021 | @ | SYN | W | 11-3 | Keuchel | L | Keuchel | Crichton | Flaherty | R | ||
| 5/6/2021 | @ | SYN | L | 0-2 | Minor | L | Minor | Wright | R | |||
| 5/7/2021 | @ | SYN | W | 4-3 | May,D | R | May,D | Britton | Dunn | R | ||
| 5/8/2021 | @ | SYN | W | 5-4 | Civale | R | Civale | Britton | Sanchez,An | R | ||
| 5/9/2021 | @ | SEA | W | 10-7 | deGrom | R | deGrom | Williams,D | Turnbull | R | ||
| 5/10/2021 | @ | SEA | W | 18-1 | Keuchel | L | Keuchel | McCullers | R | |||
| 5/11/2021 | @ | SEA | L | 4-7 | Minor | L | Minor | Senzatela | R | |||
| 5/12/2021 | @ | SEA | L | 1-3 | May,D | R | May,D | Cease | R | |||
| 5/13/2021 | @ | SEA | L | 7-13 | Civale | R | Civale | Gray,J | R | |||
| 5/15/2021 | INP | L | 1-3 | Keuchel | L | Keuchel | Valdez,F | L | ||||
| 5/16/2021 | INP | W | 8-0 | deGrom | R | deGrom | Javier | R | ||||
| 5/17/2021 | INP | L | 0-18 | Minor | L | Minor | Keller,B | R | ||||
| 5/18/2021 | INP | W | 5-4 | Civale | R | Civale | Sanchez,S | R | ||||
| 5/19/2021 | INP | W | 8-5 | May,D | R | May,D | Strasburg | R | ||||
| 5/21/2021 | @ | FOR | W | 5-0 | Keuchel | L | Keuchel | Wojciechowski | R | |||
| 5/22/2021 | @ | FOR | W | 7-4 | Minor | L | Williams,D | Britton | Pearson | R | ||
| 5/23/2021 | @ | FOR | L | 5-7 | deGrom | R | deGrom | Zeuch | R | |||
| 5/24/2021 | @ | FOR | L | 0-5 | Civale | R | Civale | Castellani | R | |||
| 5/25/2021 | @ | FOR | W | 4-3 | May,D | R | May,D | Britton | Ponce | R | ||
| 5/26/2021 | @ | FOR | L | 1-2 | Keuchel | L | Keuchel | Wojciechowski | R | |||
| 5/27/2021 | @ | BRO | L | 2-5 | Minor | L | Minor | Giolito | R | |||
| 5/28/2021 | @ | BRO | L | 7-8 | deGrom | R | deGrom | Greinke | R | |||
| 5/29/2021 | @ | BRO | W | 2-1 | Civale | R | Civale | Selman | Porcello | R | ||
| 5/30/2021 | @ | BRO | L | 1-3 | May,D | R | May,D | Buehler | R | |||
| 5/31/2021 | @ | BRO | W | 3-2 | Keuchel | L | Keuchel | Williams,D | Bieber | R | ||
| 6/1/2021 | @ | BRO | L | 6-7 | Minor | L | Kinley | Giolito | R | |||
| 6/3/2021 | DEM | W | 8-7 | Civale | R | Britton | Cueto | R | ||||
| 6/4/2021 | DEM | W | 11-5 | deGrom | R | deGrom | Hendricks | R | ||||
| 6/5/2021 | DEM | W | 6-0 | Keuchel | L | Keuchel | Heaney | L | ||||
| 6/6/2021 | DEM | W | 18-2 | Minor | L | Minor | Burnes | R | ||||
| 6/7/2021 | DEM | W | 19-9 | May,D | R | May,D | Howard,Sp | R | ||||
| 6/8/2021 | DEM | W | 9-5 | Civale | R | Williams,D | Cueto | R | ||||
| 6/9/2021 | SYN | W | 14-1 | Anderson,Bre | L | Anderson,Bre | Sanchez,An | R | ||||
| 6/10/2021 | SYN | L | 5-6 | deGrom | R | deGrom | Dunn | R | ||||
| 6/11/2021 | SYN | W | 7-5 | Keuchel | L | Williams,D | Britton | Flaherty | R | |||
| 6/12/2021 | SYN | W | 18-8 | Minor | L | Minor | Skubal | L | ||||
| 6/13/2021 | SYN | W | 5-4 | Civale | R | Britton | Alcantara,Sa | R | ||||
| 6/14/2021 | SYN | W | 11-3 | Anderson,Bre | L | Anderson,Bre | Sanchez,An | R | ||||
| 6/15/2021 | @ | DEM | W | 7-1 | deGrom | R | deGrom | Heaney | L | |||
| 6/16/2021 | @ | DEM | L | 2-6 | Keuchel | L | Keuchel | Burnes | R | |||
| 6/17/2021 | @ | DEM | W | 3-1 | Minor | L | Minor | Britton | Howard,Sp | R | ||
| 6/18/2021 | @ | DEM | W | 4-1 | Civale | R | Civale | Britton | Cueto | R | ||
| 6/19/2021 | @ | DEM | W | 9-3 | Anderson,Bre | L | Anderson,Bre | Hendricks | R | |||
| 6/20/2021 | @ | DEM | W | 4-0 | deGrom | R | deGrom | Britton | Heaney | L | ||
| 6/22/2021 | SMS | W | 7-4 | Keuchel | L | Keuchel | Williams,D | Davies | R | |||
| 6/23/2021 | SMS | W | 5-1 | Minor | L | Kinley | Williams,D | Walker,T | R | |||
| 6/24/2021 | SMS | W | 7-6 | Anderson,Bre | L | Harris | Britton | Eflin | R | |||
| 6/25/2021 | SMS | L | 6-13 | Civale | R | Civale | Perez,Ma | L | ||||
| 6/26/2021 | SMS | W | 10-1 | deGrom | R | deGrom | Cody | R | ||||
| 6/27/2021 | SMS | L | 0-3 | Keuchel | L | Keuchel | Davies | R | ||||
| 6/28/2021 | @ | RLF | L | 4-5 | Minor | L | Selman | Bundy | R | |||
| 6/29/2021 | @ | RLF | W | 16-3 | Anderson,Bre | L | Harris | Gibson | R | |||
| 6/30/2021 | @ | RLF | W | 8-1 | Civale | R | Civale | Hill,R | L | |||
| 7/1/2021 | @ | RLF | L | 4-5 | 10 | deGrom | R | McGee | Mize | R | ||
| 7/2/2021 | @ | RLF | L | 5-8 | Keuchel | L | Keuchel | Kim | L | |||
| 7/3/2021 | @ | RLF | L | 1-8 | Minor | L | Minor | Bundy | R | |||
| 7/4/2021 | @ | DSX | W | 5-1 | Anderson,Bre | L | Anderson,Bre | Britton | Lopez,P | R | ||
| 7/5/2021 | @ | DSX | W | 18-7 | Civale | R | Crichton | Kershaw | L | |||
| 7/6/2021 | @ | DSX | W | 6-5 | 11 | deGrom | R | Britton | Selman | Lester | L | |
| 7/7/2021 | @ | DSX | W | 7-4 | Keuchel | L | Keuchel | Williams,D | Fiers | R | ||
| 7/8/2021 | @ | DSX | L | 3-6 | Minor | L | Minor | Gausman | R | |||
| 7/10/2021 | SCO | W | 13-11 | Civale | R | Selman | Crichton | Kremer | R | |||
| 7/11/2021 | SCO | W | 3-2 | Anderson,Bre | L | Anderson,Bre | Britton | Lamet | R | |||
| 7/12/2021 | SCO | W | 5-1 | May,D | R | May,D | Bassitt | R | ||||
| 7/13/2021 | SCO | W | 5-2 | Keuchel | L | Keuchel | Williams,D | Duffy | L | |||
| 7/14/2021 | SCO | W | 5-2 | deGrom | R | deGrom | Castillo,L | R | ||||
| 7/16/2021 | @ | PEA | L | 8-11 | Civale | R | Civale | Montas | R | |||
| 7/17/2021 | @ | PEA | L | 4-5 | Anderson,Bre | L | Britton | Arrieta | R | |||
| 7/18/2021 | @ | PEA | W | 6-1 | May,D | R | May,D | Barria | R | |||
| 7/19/2021 | @ | PEA | W | 5-2 | Keuchel | L | Keuchel | Britton | Singer | R | ||
| 7/20/2021 | @ | PEA | W | 2-1 | deGrom | R | deGrom | Britton | Plesac | R | ||
| 7/23/2021 | @ | SMS | L | 12-13 | 11 | Civale | R | Williams,D | Houser | R | ||
| 7/24/2021 | @ | SMS | L | 2-5 | Anderson,Bre | L | Anderson,Bre | Davies | R | |||
| 7/25/2021 | @ | SMS | W | 12-6 | May,D | R | May,D | Garcia,LH | Walker,T | R | ||
| 7/26/2021 | @ | SMS | L | 5-6 | Minor | L | Minor | Eflin | R | |||
| 7/27/2021 | @ | SMS | W | 2-1 | deGrom | R | deGrom | Britton | Perez,Ma | L | ||
| 7/28/2021 | @ | SMS | L | 3-4 | Civale | R | Civale | Houser | R | |||
| 7/29/2021 | COM | W | 6-4 | Anderson,Bre | L | Anderson,Bre | Britton | Hernandez,El | R | |||
| 7/30/2021 | COM | L | 3-4 | 11 | May,D | R | Garcia,LH | Luzardo | L | |||
| 7/31/2021 | COM | W | 8-6 | Minor | L | Crichton | Britton | Hudson,Dak | R | |||
| 8/1/2021 | COM | W | 4-0 | deGrom | R | deGrom | Snell | L | ||||
| 8/2/2021 | COM | W | 4-3 | Civale | R | Crichton | Williams,D | Boyd | L | |||
| 8/3/2021 | COM | W | 4-3 | Anderson,Bre | L | Garcia,LH | Hernandez,El | R | ||||
| 8/4/2021 | PHO | W | 8-5 | Bailey,H | R | Armstrong | Garcia,LH | Carrasco | R | |||
| 8/5/2021 | PHO | W | 10-6 | May,D | R | May,D | Garcia,LH | Clevinger | R | |||
| 8/6/2021 | PHO | W | 6-0 | deGrom | R | deGrom | Fried | L | ||||
| 8/7/2021 | PHO | L | 5-10 | Minor | L | Minor | Manaea | L | ||||
| 8/8/2021 | PHO | W | 7-4 | Anderson,Bre | L | Armstrong | Selman | Ryu | L | |||
| 8/10/2021 | DUT | W | 12-3 | May,D | R | May,D | Marquez,G | R | ||||
| 8/11/2021 | DUT | W | 7-3 | Keuchel | L | Keuchel | Cole,G | R | ||||
| 8/12/2021 | DUT | W | 14-1 | deGrom | R | deGrom | Lorenzen | R | ||||
| 8/13/2021 | DUT | W | 9-4 | Minor | L | Minor | Corbin | L | ||||
| 8/14/2021 | DUT | W | 12-5 | Anderson,Bre | L | Anderson,Bre | Smeltzer | L | ||||
| 8/15/2021 | DUT | W | 7-4 | May,D | R | May,D | Marquez,G | R | ||||
| 8/16/2021 | RLF | W | 15-4 | Keuchel | L | Keuchel | Gibson | R | ||||
| 8/17/2021 | RLF | W | 13-7 | Bailey,H | R | Bailey,H | Hill,R | L | ||||
| 8/18/2021 | RLF | W | 6-5 | deGrom | R | deGrom | Britton | Mize | R | |||
| 8/19/2021 | RLF | W | 9-7 | 10 | Anderson,Bre | L | Britton | Roark | R | |||
| 8/20/2021 | RLF | W | 13-6 | May,D | R | May,D | Bundy | R | ||||
| 8/21/2021 | RLF | L | 2-3 | Keuchel | L | Keuchel | Gibson | R | ||||
| 8/23/2021 | SLG | W | 12-2 | deGrom | R | deGrom | Martinez,C | R | ||||
| 8/24/2021 | SLG | W | 9-3 | Anderson,Bre | L | Anderson,Bre | Richards,T | R | ||||
| 8/25/2021 | SLG | W | 14-4 | May,D | R | May,D | Weaver | R | ||||
| 8/26/2021 | SLG | W | 8-0 | Keuchel | L | Keuchel | LeBlanc | L | ||||
| 8/27/2021 | SLG | W | 9-2 | Civale | R | Civale | Cobb | R | ||||
| 8/28/2021 | @ | STO | L | 7-8 | 13 | deGrom | R | Crichton | McKenzie | R | ||
| 8/29/2021 | @ | STO | L | 5-10 | Anderson,Bre | L | Anderson,Bre | Lynn | R | |||
| 8/30/2021 | @ | STO | L | 2-4 | May,D | R | May,D | Wheeler | R | |||
| 8/31/2021 | @ | STO | L | 3-8 | Keuchel | L | Keuchel | Urias,J | L | |||
| 9/1/2021 | @ | STO | W | 4-1 | Minor | L | Minor | Britton | Musgrove | R | ||
| 9/2/2021 | @ | DRI | W | 12-3 | deGrom | R | deGrom | Thorpe | L | |||
| 9/3/2021 | @ | DRI | W | 11-1 | Bailey,H | R | Bailey,H | Rosso | R | |||
| 9/4/2021 | @ | DRI | L | 1-4 | May,D | R | May,D | Rea | R | |||
| 9/5/2021 | @ | DRI | W | 4-1 | Keuchel | L | Keuchel | Williams,D | Mahle | R | ||
| 9/6/2021 | @ | DRI | W | 8-6 | 10 | Anderson,Bre | L | Britton | Williams,D | Zimmermann,B | L | |
| 9/8/2021 | STO | W | 6-0 | deGrom | R | deGrom | Lynn | R | ||||
| 9/9/2021 | STO | W | 5-3 | May,D | R | May,D | Williams,D | Wheeler | R | |||
| 9/10/2021 | STO | L | 1-2 | Keuchel | L | Keuchel | Urias,J | L | ||||
| 9/11/2021 | STO | W | 12-1 | Anderson,Bre | L | Anderson,Bre | Musgrove | R | ||||
| 9/12/2021 | STO | L | 4-6 | Civale | R | Civale | McKenzie | R | ||||
| 9/13/2021 | @ | SLG | W | 6-5 | deGrom | R | deGrom | Williams,D | Montgomery,M | L | ||
| 9/14/2021 | @ | SLG | L | 4-6 | Bailey,H | R | Bailey,H | Martinez,C | R | |||
| 9/15/2021 | @ | SLG | W | 9-0 | May,D | R | May,D | Armstrong | Richards,T | R | ||
| 9/16/2021 | @ | SLG | W | 12-6 | Keuchel | L | Keuchel | Weaver | R | |||
| 9/17/2021 | @ | SLG | L | 0-3 | Anderson,Bre | L | Anderson,Bre | LeBlanc | L | |||
| 9/18/2021 | DRI | W | 7-1 | deGrom | R | deGrom | Espino | R | ||||
| 9/19/2021 | DRI | W | 8-5 | Bailey,H | R | McGee | Williams,D | Thorpe | L | |||
| 9/20/2021 | DRI | W | 11-2 | May,D | R | May,D | Rosso | R | ||||
| 9/21/2021 | DRI | W | 11-3 | Keuchel | L | Keuchel | Medina | R | ||||
| 9/22/2021 | DRI | W | 9-4 | Anderson,Bre | L | Anderson,Bre | Rea | R | ||||
| Other | |||||||||||||
| Cumulative | |||||||||||||
| Date | # | Opp | GWRBI | RF | RA | W | L | Pct | Last10 | Strk | Gm# | ||
| 4/1/2021 | @ | DRI | W | 2 | 1 | 1 | 0 | 1.000 | 1-0 | W1 | 1 | ||
| 4/2/2021 | @ | DRI | W | McCann | 14 | 1 | 2 | 0 | 1.000 | 2-0 | W2 | 2 | |
| 4/3/2021 | @ | DRI | W | Rendon | 3 | 2 | 3 | 0 | 1.000 | 3-0 | W3 | 3 | |
| 4/4/2021 | @ | DRI | W | McCann | 15 | 2 | 4 | 0 | 1.000 | 4-0 | W4 | 4 | |
| 4/5/2021 | @ | DRI | W | Machado | 13 | 7 | 5 | 0 | 1.000 | 5-0 | W5 | 5 | |
| 4/6/2021 | @ | SLG | W | Machado | 4 | 3 | 6 | 0 | 1.000 | 6-0 | W6 | 6 | |
| 4/7/2021 | @ | SLG | W | Rendon | 9 | 4 | 7 | 0 | 1.000 | 7-0 | W7 | 7 | |
| 4/8/2021 | @ | SLG | W | McCann | 5 | 2 | 8 | 0 | 1.000 | 8-0 | W8 | 8 | |
| 4/9/2021 | @ | SLG | L | 6 | 7 | 8 | 1 | .889 | 8-1 | L1 | 9 | ||
| 4/10/2021 | @ | SLG | W | Yelich | 1 | 0 | 9 | 1 | .900 | 9-1 | W1 | 10 | |
| 4/11/2021 | STO | W | Machado | 11 | 6 | 10 | 1 | .909 | 9-1 | W2 | 11 | ||
| 4/12/2021 | STO | L | 2 | 4 | 10 | 2 | .833 | 8-2 | L1 | 12 | |||
| 4/13/2021 | STO | W | 14 | 0 | 11 | 2 | .846 | 8-2 | W1 | 13 | |||
| 4/14/2021 | STO | L | 7 | 10 | 11 | 3 | .786 | 7-3 | L1 | 14 | |||
| 4/15/2021 | STO | W | Martinez,JD | 8 | 5 | 12 | 3 | .800 | 7-3 | W1 | 15 | ||
| 4/17/2021 | DRI | W | Wendle | 6 | 1 | 13 | 3 | .813 | 7-3 | W2 | 16 | ||
| 4/18/2021 | DRI | W | Mondesi | 15 | 5 | 14 | 3 | .824 | 7-3 | W3 | 17 | ||
| 4/19/2021 | DRI | W | Voit | 8 | 0 | 15 | 3 | .833 | 7-3 | W4 | 18 | ||
| 4/20/2021 | DRI | W | Voit | 8 | 2 | 16 | 3 | .842 | 8-2 | W5 | 19 | ||
| 4/21/2021 | DRI | L | 4 | 9 | 16 | 4 | .800 | 7-3 | L1 | 20 | |||
| 4/22/2021 | @ | STO | W | Machado | 7 | 0 | 17 | 4 | .810 | 7-3 | W1 | 21 | |
| 4/23/2021 | @ | STO | W | Voit | 17 | 6 | 18 | 4 | .818 | 8-2 | W2 | 22 | |
| 4/24/2021 | @ | STO | W | Kemp,T | 4 | 1 | 19 | 4 | .826 | 8-2 | W3 | 23 | |
| 4/25/2021 | @ | STO | W | Grandal | 5 | 1 | 20 | 4 | .833 | 9-1 | W4 | 24 | |
| 4/26/2021 | @ | STO | L | 0 | 8 | 20 | 5 | .800 | 8-2 | L1 | 25 | ||
| 4/27/2021 | SLG | W | Rendon | 8 | 1 | 21 | 5 | .808 | 8-2 | W1 | 26 | ||
| 4/28/2021 | SLG | W | Yelich | 3 | 2 | 22 | 5 | .815 | 8-2 | W2 | 27 | ||
| 4/29/2021 | SLG | W | Wendle | 9 | 2 | 23 | 5 | .821 | 8-2 | W3 | 28 | ||
| 4/30/2021 | SLG | W | 7 | 5 | 24 | 5 | .828 | 8-2 | W4 | 29 | |||
| 5/1/2021 | SLG | W | Wendle | 10 | 4 | 25 | 5 | .833 | 9-1 | W5 | 30 | ||
| 5/3/2021 | @ | SYN | W | Pham | 12 | 4 | 26 | 5 | .839 | 9-1 | W6 | 31 | |
| 5/4/2021 | @ | SYN | W | Pham | 15 | 1 | 27 | 5 | .844 | 9-1 | W7 | 32 | |
| 5/5/2021 | @ | SYN | W | Pham | 11 | 3 | 28 | 5 | .848 | 9-1 | W8 | 33 | |
| 5/6/2021 | @ | SYN | L | 0 | 2 | 28 | 6 | .824 | 8-2 | L1 | 34 | ||
| 5/7/2021 | @ | SYN | W | Mondesi | 4 | 3 | 29 | 6 | .829 | 9-1 | W1 | 35 | |
| 5/8/2021 | @ | SYN | W | Berti | 5 | 4 | 30 | 6 | .833 | 9-1 | W2 | 36 | |
| 5/9/2021 | @ | SEA | W | Rendon | 10 | 7 | 31 | 6 | .838 | 9-1 | W3 | 37 | |
| 5/10/2021 | @ | SEA | W | Gimenez | 18 | 1 | 32 | 6 | .842 | 9-1 | W4 | 38 | |
| 5/11/2021 | @ | SEA | L | 4 | 7 | 32 | 7 | .821 | 8-2 | L1 | 39 | ||
| 5/12/2021 | @ | SEA | L | 1 | 3 | 32 | 8 | .800 | 7-3 | L2 | 40 | ||
| 5/13/2021 | @ | SEA | L | 7 | 13 | 32 | 9 | .780 | 6-4 | L3 | 41 | ||
| 5/15/2021 | INP | L | 1 | 3 | 32 | 10 | .762 | 5-5 | L4 | 42 | |||
| 5/16/2021 | INP | W | Knapp | 8 | 0 | 33 | 10 | .767 | 5-5 | W1 | 43 | ||
| 5/17/2021 | INP | L | 0 | 18 | 33 | 11 | .750 | 5-5 | L1 | 44 | |||
| 5/18/2021 | INP | W | Knapp | 5 | 4 | 34 | 11 | .756 | 5-5 | W1 | 45 | ||
| 5/19/2021 | INP | W | Wendle | 8 | 5 | 35 | 11 | .761 | 5-5 | W2 | 46 | ||
| 5/21/2021 | @ | FOR | W | Mondesi | 5 | 0 | 36 | 11 | .766 | 5-5 | W3 | 47 | |
| 5/22/2021 | @ | FOR | W | Yelich | 7 | 4 | 37 | 11 | .771 | 5-5 | W4 | 48 | |
| 5/23/2021 | @ | FOR | L | 5 | 7 | 37 | 12 | .755 | 5-5 | L1 | 49 | ||
| 5/24/2021 | @ | FOR | L | 0 | 5 | 37 | 13 | .740 | 5-5 | L2 | 50 | ||
| 5/25/2021 | @ | FOR | W | Yelich | 4 | 3 | 38 | 13 | .745 | 6-4 | W1 | 51 | |
| 5/26/2021 | @ | FOR | L | 1 | 2 | 38 | 14 | .731 | 6-4 | L1 | 52 | ||
| 5/27/2021 | @ | BRO | L | 2 | 5 | 38 | 15 | .717 | 5-5 | L2 | 53 | ||
| 5/28/2021 | @ | BRO | L | 7 | 8 | 38 | 16 | .704 | 5-5 | L3 | 54 | ||
| 5/29/2021 | @ | BRO | W | McCann | 2 | 1 | 39 | 16 | .709 | 5-5 | W1 | 55 | |
| 5/30/2021 | @ | BRO | L | 1 | 3 | 39 | 17 | .696 | 4-6 | L1 | 56 | ||
| 5/31/2021 | @ | BRO | W | Machado | 3 | 2 | 40 | 17 | .702 | 4-6 | W1 | 57 | |
| 6/1/2021 | @ | BRO | L | 6 | 7 | 40 | 18 | .690 | 3-7 | L1 | 58 | ||
| 6/3/2021 | DEM | W | 8 | 7 | 41 | 18 | .695 | 4-6 | W1 | 59 | |||
| 6/4/2021 | DEM | W | Kemp,T | 11 | 5 | 42 | 18 | .700 | 5-5 | W2 | 60 | ||
| 6/5/2021 | DEM | W | Mondesi | 6 | 0 | 43 | 18 | .705 | 5-5 | W3 | 61 | ||
| 6/6/2021 | DEM | W | Grandal | 18 | 2 | 44 | 18 | .710 | 6-4 | W4 | 62 | ||
| 6/7/2021 | DEM | W | Knapp | 19 | 9 | 45 | 18 | .714 | 7-3 | W5 | 63 | ||
| 6/8/2021 | DEM | W | Pham | 9 | 5 | 46 | 18 | .719 | 8-2 | W6 | 64 | ||
| 6/9/2021 | SYN | W | Voit | 14 | 1 | 47 | 18 | .723 | 8-2 | W7 | 65 | ||
| 6/10/2021 | SYN | L | 5 | 6 | 47 | 19 | .712 | 8-2 | L1 | 66 | |||
| 6/11/2021 | SYN | W | McCann | 7 | 5 | 48 | 19 | .716 | 8-2 | W1 | 67 | ||
| 6/12/2021 | SYN | W | Mondesi | 18 | 8 | 49 | 19 | .721 | 9-1 | W2 | 68 | ||
| 6/13/2021 | SYN | W | Mondesi | 5 | 4 | 50 | 19 | .725 | 9-1 | W3 | 69 | ||
| 6/14/2021 | SYN | W | Wendle | 11 | 3 | 51 | 19 | .729 | 9-1 | W4 | 70 | ||
| 6/15/2021 | @ | DEM | W | Voit | 7 | 1 | 52 | 19 | .732 | 9-1 | W5 | 71 | |
| 6/16/2021 | @ | DEM | L | 2 | 6 | 52 | 20 | .722 | 8-2 | L1 | 72 | ||
| 6/17/2021 | @ | DEM | W | Machado | 3 | 1 | 53 | 20 | .726 | 8-2 | W1 | 73 | |
| 6/18/2021 | @ | DEM | W | 4 | 1 | 54 | 20 | .730 | 8-2 | W2 | 74 | ||
| 6/19/2021 | @ | DEM | W | Machado | 9 | 3 | 55 | 20 | .733 | 8-2 | W3 | 75 | |
| 6/20/2021 | @ | DEM | W | Voit | 4 | 0 | 56 | 20 | .737 | 9-1 | W4 | 76 | |
| 6/22/2021 | SMS | W | Voit | 7 | 4 | 57 | 20 | .740 | 9-1 | W5 | 77 | ||
| 6/23/2021 | SMS | W | Mondesi | 5 | 1 | 58 | 20 | .744 | 9-1 | W6 | 78 | ||
| 6/24/2021 | SMS | W | Machado | 7 | 6 | 59 | 20 | .747 | 9-1 | W7 | 79 | ||
| 6/25/2021 | SMS | L | 6 | 13 | 59 | 21 | .738 | 8-2 | L1 | 80 | |||
| 6/26/2021 | SMS | W | Voit | 10 | 1 | 60 | 21 | .741 | 8-2 | W1 | 81 | ||
| 6/27/2021 | SMS | L | 0 | 3 | 60 | 22 | .732 | 8-2 | L1 | 82 | |||
| 6/28/2021 | @ | RLF | L | 4 | 5 | 60 | 23 | .723 | 7-3 | L2 | 83 | ||
| 6/29/2021 | @ | RLF | W | Yelich | 16 | 3 | 61 | 23 | .726 | 7-3 | W1 | 84 | |
| 6/30/2021 | @ | RLF | W | Mondesi | 8 | 1 | 62 | 23 | .729 | 7-3 | W2 | 85 | |
| 7/1/2021 | @ | RLF | L | 4 | 5 | 62 | 24 | .721 | 6-4 | L1 | 86 | ||
| 7/2/2021 | @ | RLF | L | 5 | 8 | 62 | 25 | .713 | 5-5 | L2 | 87 | ||
| 7/3/2021 | @ | RLF | L | 1 | 8 | 62 | 26 | .705 | 4-6 | L3 | 88 | ||
| 7/4/2021 | @ | DSX | W | Voit | 5 | 1 | 63 | 26 | .708 | 4-6 | W1 | 89 | |
| 7/5/2021 | @ | DSX | W | Yelich | 18 | 7 | 64 | 26 | .711 | 5-5 | W2 | 90 | |
| 7/6/2021 | @ | DSX | W | Machado | 6 | 5 | 65 | 26 | .714 | 5-5 | W3 | 91 | |
| 7/7/2021 | @ | DSX | W | Machado | 7 | 4 | 66 | 26 | .717 | 6-4 | W4 | 92 | |
| 7/8/2021 | @ | DSX | L | 3 | 6 | 66 | 27 | .710 | 6-4 | L1 | 93 | ||
| 7/10/2021 | SCO | W | Voit | 13 | 11 | 67 | 27 | .713 | 6-4 | W1 | 94 | ||
| 7/11/2021 | SCO | W | Machado | 3 | 2 | 68 | 27 | .716 | 6-4 | W2 | 95 | ||
| 7/12/2021 | SCO | W | Grandal | 5 | 1 | 69 | 27 | .719 | 7-3 | W3 | 96 | ||
| 7/13/2021 | SCO | W | Voit | 5 | 2 | 70 | 27 | .722 | 8-2 | W4 | 97 | ||
| 7/14/2021 | SCO | W | La Stella | 5 | 2 | 71 | 27 | .724 | 9-1 | W5 | 98 | ||
| 7/16/2021 | @ | PEA | L | 8 | 11 | 71 | 28 | .717 | 8-2 | L1 | 99 | ||
| 7/17/2021 | @ | PEA | L | 4 | 5 | 71 | 29 | .710 | 7-3 | L2 | 100 | ||
| 7/18/2021 | @ | PEA | W | Machado | 6 | 1 | 72 | 29 | .713 | 7-3 | W1 | 101 | |
| 7/19/2021 | @ | PEA | W | Knapp | 5 | 2 | 73 | 29 | .716 | 7-3 | W2 | 102 | |
| 7/20/2021 | @ | PEA | W | Heyward | 2 | 1 | 74 | 29 | .718 | 8-2 | W3 | 103 | |
| 7/23/2021 | @ | SMS | L | 12 | 13 | 74 | 30 | .712 | 7-3 | L1 | 104 | ||
| 7/24/2021 | @ | SMS | L | 2 | 5 | 74 | 31 | .705 | 6-4 | L2 | 105 | ||
| 7/25/2021 | @ | SMS | W | Berti | 12 | 6 | 75 | 31 | .708 | 6-4 | W1 | 106 | |
| 7/26/2021 | @ | SMS | L | 5 | 6 | 75 | 32 | .701 | 5-5 | L1 | 107 | ||
| 7/27/2021 | @ | SMS | W | Pham | 2 | 1 | 76 | 32 | .704 | 5-5 | W1 | 108 | |
| 7/28/2021 | @ | SMS | L | 3 | 4 | 76 | 33 | .697 | 5-5 | L1 | 109 | ||
| 7/29/2021 | COM | W | Heyward | 6 | 4 | 77 | 33 | .700 | 6-4 | W1 | 110 | ||
| 7/30/2021 | COM | L | 3 | 4 | 77 | 34 | .694 | 5-5 | L1 | 111 | |||
| 7/31/2021 | COM | W | Voit | 8 | 6 | 78 | 34 | .696 | 5-5 | W1 | 112 | ||
| 8/1/2021 | COM | W | Mondesi | 4 | 0 | 79 | 34 | .699 | 5-5 | W2 | 113 | ||
| 8/2/2021 | COM | W | Voit | 4 | 3 | 80 | 34 | .702 | 6-4 | W3 | 114 | ||
| 8/3/2021 | COM | W | Rendon | 4 | 3 | 81 | 34 | .704 | 7-3 | W4 | 115 | ||
| 8/4/2021 | PHO | W | Knapp | 8 | 5 | 82 | 34 | .707 | 7-3 | W5 | 116 | ||
| 8/5/2021 | PHO | W | Voit | 10 | 6 | 83 | 34 | .709 | 8-2 | W6 | 117 | ||
| 8/6/2021 | PHO | W | Mondesi | 6 | 0 | 84 | 34 | .712 | 8-2 | W7 | 118 | ||
| 8/7/2021 | PHO | L | 5 | 10 | 84 | 35 | .706 | 8-2 | L1 | 119 | |||
| 8/8/2021 | PHO | W | Rendon | 7 | 4 | 85 | 35 | .708 | 8-2 | W1 | 120 | ||
| 8/10/2021 | DUT | W | Wendle | 12 | 3 | 86 | 35 | .711 | 9-1 | W2 | 121 | ||
| 8/11/2021 | DUT | W | Machado | 7 | 3 | 87 | 35 | .713 | 9-1 | W3 | 122 | ||
| 8/12/2021 | DUT | W | La Stella | 14 | 1 | 88 | 35 | .715 | 9-1 | W4 | 123 | ||
| 8/13/2021 | DUT | W | Pham | 9 | 4 | 89 | 35 | .718 | 9-1 | W5 | 124 | ||
| 8/14/2021 | DUT | W | Machado | 12 | 5 | 90 | 35 | .720 | 9-1 | W6 | 125 | ||
| 8/15/2021 | DUT | W | Voit | 7 | 4 | 91 | 35 | .722 | 9-1 | W7 | 126 | ||
| 8/16/2021 | RLF | W | Machado | 15 | 4 | 92 | 35 | .724 | 9-1 | W8 | 127 | ||
| 8/17/2021 | RLF | W | Machado | 13 | 7 | 93 | 35 | .727 | 9-1 | W9 | 128 | ||
| 8/18/2021 | RLF | W | Voit | 6 | 5 | 94 | 35 | .729 | 10-0 | W10 | 129 | ||
| 8/19/2021 | RLF | W | La Stella | 9 | 7 | 95 | 35 | .731 | 10-0 | W11 | 130 | ||
| 8/20/2021 | RLF | W | Voit | 13 | 6 | 96 | 35 | .733 | 10-0 | W12 | 131 | ||
| 8/21/2021 | RLF | L | 2 | 3 | 96 | 36 | .727 | 9-1 | L1 | 132 | |||
| 8/23/2021 | SLG | W | Davis,Jo | 12 | 2 | 97 | 36 | .729 | 9-1 | W1 | 133 | ||
| 8/24/2021 | SLG | W | Machado | 9 | 3 | 98 | 36 | .731 | 9-1 | W2 | 134 | ||
| 8/25/2021 | SLG | W | Grandal | 14 | 4 | 99 | 36 | .733 | 9-1 | W3 | 135 | ||
| 8/26/2021 | SLG | W | Machado | 8 | 0 | 100 | 36 | .735 | 9-1 | W4 | 136 | ||
| 8/27/2021 | SLG | W | La Stella | 9 | 2 | 101 | 36 | .737 | 9-1 | W5 | 137 | ||
| 8/28/2021 | @ | STO | L | 7 | 8 | 101 | 37 | .732 | 8-2 | L1 | 138 | ||
| 8/29/2021 | @ | STO | L | 5 | 10 | 101 | 38 | .727 | 7-3 | L2 | 139 | ||
| 8/30/2021 | @ | STO | L | 2 | 4 | 101 | 39 | .721 | 6-4 | L3 | 140 | ||
| 8/31/2021 | @ | STO | L | 3 | 8 | 101 | 40 | .716 | 5-5 | L4 | 141 | ||
| 9/1/2021 | @ | STO | W | Knapp | 4 | 1 | 102 | 40 | .718 | 6-4 | W1 | 142 | |
| 9/2/2021 | @ | DRI | W | Machado | 12 | 3 | 103 | 40 | .720 | 6-4 | W2 | 143 | |
| 9/3/2021 | @ | DRI | W | Knapp | 11 | 1 | 104 | 40 | .722 | 6-4 | W3 | 144 | |
| 9/4/2021 | @ | DRI | L | 1 | 4 | 104 | 41 | .717 | 5-5 | L1 | 145 | ||
| 9/5/2021 | @ | DRI | W | Kemp,T | 4 | 1 | 105 | 41 | .719 | 5-5 | W1 | 146 | |
| 9/6/2021 | @ | DRI | W | Heyward | 8 | 6 | 106 | 41 | .721 | 5-5 | W2 | 147 | |
| 9/8/2021 | STO | W | Davis,Jo | 6 | 0 | 107 | 41 | .723 | 6-4 | W3 | 148 | ||
| 9/9/2021 | STO | W | Yelich | 5 | 3 | 108 | 41 | .725 | 7-3 | W4 | 149 | ||
| 9/10/2021 | STO | L | 1 | 2 | 108 | 42 | .720 | 7-3 | L1 | 150 | |||
| 9/11/2021 | STO | W | Knapp | 12 | 1 | 109 | 42 | .722 | 8-2 | W1 | 151 | ||
| 9/12/2021 | STO | L | 4 | 6 | 109 | 43 | .717 | 7-3 | L1 | 152 | |||
| 9/13/2021 | @ | SLG | W | Mondesi | 6 | 5 | 110 | 43 | .719 | 7-3 | W1 | 153 | |
| 9/14/2021 | @ | SLG | L | 4 | 6 | 110 | 44 | .714 | 6-4 | L1 | 154 | ||
| 9/15/2021 | @ | SLG | W | Berti | 9 | 0 | 111 | 44 | .716 | 7-3 | W1 | 155 | |
| 9/16/2021 | @ | SLG | W | McCann | 12 | 6 | 112 | 44 | .718 | 7-3 | W2 | 156 | |
| 9/17/2021 | @ | SLG | L | 0 | 3 | 112 | 45 | .713 | 6-4 | L1 | 157 | ||
| 9/18/2021 | DRI | W | Machado | 7 | 1 | 113 | 45 | .715 | 6-4 | W1 | 158 | ||
| 9/19/2021 | DRI | W | Heyward | 8 | 5 | 114 | 45 | .717 | 6-4 | W2 | 159 | ||
| 9/20/2021 | DRI | W | Gimenez | 11 | 2 | 115 | 45 | .719 | 7-3 | W3 | 160 | ||
| 9/21/2021 | DRI | W | Voit | 11 | 3 | 116 | 45 | .720 | 7-3 | W4 | 161 | ||
| 9/22/2021 | DRI | W | La Stella | 9 | 4 | 117 | 45 | .722 | 8-2 | W5 | 162 | ||