League injury log -- National
Regular season -- as of 10/28/2022
| Injuries |
| Date | # | Team | Player | Cause | Dur |
| 4/1/2022 | | STO | Alfaro | General | 1 |
| 4/1/2022 | | SLG | Cobb | General | 11 |
| 4/1/2022 | | RLF | Duvall | General | 3 |
| 4/1/2022 | | COM | Tapia,R | General | 29 |
| 4/2/2022 | | DRI | Robles,V | General | 5 |
| 4/2/2022 | | DEM | Montgomery | General | 1 |
| 4/2/2022 | | COM | Adrianza | General | 6 |
| 4/2/2022 | | COM | Turner,T | General | 7 |
| 4/3/2022 | | DRI | Brinson | Hit by pitch | 1 |
| 4/3/2022 | | SLG | Gomber | General | 41 |
| 4/4/2022 | | CLE | Machado,M | General | 4 |
| 4/4/2022 | | SLG | Whitley | General | 1 |
| 4/5/2022 | | DRI | Manoah | Hit by pitch | 19 |
| 4/5/2022 | | SMS | Odorizzi | General | 16 |
| 4/5/2022 | | SMS | Strickland | General | 1 |
| 4/6/2022 | | CLE | deGrom | General | 16 |
| 4/7/2022 | | DRI | Wacha | General | 1 |
| 4/8/2022 | | BRO | Giolito | General | 1 |
| 4/9/2022 | | BRO | Rizzo | General | 21 |
| 4/9/2022 | | SLG | India | General | 6 |
| 4/9/2022 | | RLF | Bumgarner | General | 26 |
| 4/10/2022 | | BRO | Quintana | General | 6 |
| 4/10/2022 | | DEM | Rojas,JL | Collision on bases | 24 |
| 4/10/2022 | | DUT | Stassi | Hit by pitch | 1 |
| 4/11/2022 | | SMS | Boxberger | General | 3 |
| 4/12/2022 | | DRI | Franco,W | General | 9 |
| 4/12/2022 | | FOR | Dickerson,A | General | 1 |
| 4/12/2022 | | FOR | Escobar,E | General | 10 |
| 4/13/2022 | | DEM | Wood,A | General | 6 |
| 4/13/2022 | | COM | Bell | General | 1 |
| 4/13/2022 | | COM | Ross | General | 6 |
| 4/14/2022 | | STO | Lynn | General | 11 |
| 4/14/2022 | | DUT | Stassi | Hit by pitch | 19 |
| 4/14/2022 | | SYN | Flaherty | General | 1 |
| 4/14/2022 | | COM | Arozarena | Hit by pitch | 20 |
| 4/15/2022 | | SYN | France | General | 10 |
| 4/15/2022 | | SYN | Rogers,Ja | General | 17 |
| 4/17/2022 | | DEM | Baez,J | Brawl | 20 |
| 4/17/2022 | | STO | Culberson | General | 14 |
| 4/18/2022 | | CLE | Wendle | General | 1 |
| 4/19/2022 | | SMS | Gordon | Collision on bases | 6 |
| 4/20/2022 | | CLE | Finnegan | General | 1 |
| 4/21/2022 | | DEM | Fletcher,D | General | 1 |
| 4/21/2022 | | DEM | Varsho | General | 3 |
| 4/22/2022 | | DUT | Margot | General | 6 |
| 4/23/2022 | | COM | Springer | General | 1 |
| 4/23/2022 | | FOR | Dickerson,A | Collision on bases | 1 |
| 4/26/2022 | | SMS | Schoop | General | 1 |
| 4/26/2022 | | RLF | Wong,Ko | Hit by pitch | 1 |
| 4/27/2022 | | SMS | Rodon | General | 1 |
| 4/27/2022 | | DEM | Crawford,JP | General | 1 |
| 4/27/2022 | | STO | Culberson | General | 20 |
| 4/28/2022 | | DEM | Anderson,Bri | Hit by pitch | 1 |
| 4/29/2022 | | SLG | Gomber | General | 1 |
| 4/29/2022 | | COM | Crochet | General | 1 |
| 4/29/2022 | | RLF | Duvall | General | 5 |
| 4/30/2022 | | DUT | Nootbaar | General | 3 |
| 4/30/2022 | | CLE | Minor | General | 1 |
| 5/1/2022 | | DEM | Toussaint | General | 23 |
| 5/1/2022 | | DUT | Loaisiga | General | 1 |
| 5/1/2022 | | CLE | Heyward | General | 16 |
| 5/1/2022 | | RLF | Garver | General | 20 |
| 5/3/2022 | | DEM | Crawford,JP | General | 1 |
| 5/4/2022 | | SMS | Bogaerts | General | 2 |
| 5/6/2022 | | STO | Culberson | General | 4 |
| 5/7/2022 | | STO | McKenzie | General | 1 |
| 5/7/2022 | | STO | Stephenson,R | General | 1 |
| 5/9/2022 | | STO | Urias,J | General | 26 |
| 5/9/2022 | | DUT | Margot | General | 1 |
| 5/10/2022 | | DEM | Varsho | General | 1 |
| 5/10/2022 | | DRI | Brinson | General | 1 |
| 5/11/2022 | | SLG | India | Collision on bases | 13 |
| 5/11/2022 | | FOR | Gutierrez,V | General | 1 |
| 5/14/2022 | | BRO | Rizzo | General | 2 |
| 5/15/2022 | | RLF | Daza | General | 4 |
| 5/16/2022 | | SLG | Whitley | General | 1 |
| 5/16/2022 | | SMS | Gurriel,L | Hit by pitch | 1 |
| 5/16/2022 | | SMS | Mountcastle | General | 2 |
| 5/17/2022 | | CLE | Garcia,LH | General | 11 |
| 5/17/2022 | | SLG | Kelly,C | General | 1 |
| 5/17/2022 | | RLF | Bumgarner | General | 11 |
| 5/18/2022 | | COM | Luzardo | General | 1 |
| 5/19/2022 | | FOR | Rogers,Tr | General | 21 |
| 5/19/2022 | | SYN | Ruiz,J | General | 4 |
| 5/20/2022 | | CLE | deGrom | General | 1 |
| 5/21/2022 | | STO | Alfaro | General | 16 |
| 5/21/2022 | | DEM | Wood,A | General | 26 |
| 5/21/2022 | | SYN | France | General | 7 |
| 5/21/2022 | | SYN | McMahon | General | 11 |
| 5/21/2022 | | RLF | Hernandez,T | General | 14 |
| 5/23/2022 | | SLG | India | Hit by pitch | 13 |
| 5/24/2022 | | COM | Naylor | Hit by pitch | 1 |
| 5/26/2022 | | CLE | Heyward | General | 21 |
| 5/27/2022 | | SLG | Kelly,C | General | 2 |
| 5/27/2022 | | SLG | Ward | Hit by pitch | 7 |
| 5/27/2022 | | SMS | Watson | General | 21 |
| 5/29/2022 | | SYN | Tatis | General | 1 |
| 6/3/2022 | | DEM | Quantrill | General | 1 |
| 6/3/2022 | | COM | Kowar | General | 16 |
| 6/4/2022 | | SMS | Alonso | General | 10 |
| 6/4/2022 | | DUT | Adames | General | 3 |
| 6/4/2022 | | RLF | Hernandez,Ya | General | 17 |
| 6/5/2022 | | DRI | Johnson,Da | General | 13 |
| 6/5/2022 | | STO | Correa | General | 10 |
| 6/10/2022 | | COM | Zunino | General | 1 |
| 6/11/2022 | | STO | Urias,J | General | 1 |
| 6/12/2022 | | DUT | Urquidy | General | 25 |
| 6/13/2022 | | DEM | Quantrill | General | 1 |
| 6/13/2022 | | DRI | Robert | General | 4 |
| 6/14/2022 | | FOR | Chisholm | General | 7 |
| 6/16/2022 | | DRI | Franco,W | General | 1 |
| 6/16/2022 | | FOR | Santander | General | 32 |
| 6/17/2022 | | SYN | Kepler | Hit by pitch | 7 |
| 6/18/2022 | | STO | Pederson | General | 2 |
| 6/18/2022 | | STO | Solano | Hit by pitch | 27 |
| 6/18/2022 | | BRO | Kieboom | General | 7 |
| 6/18/2022 | | SLG | Weaver | General | 26 |
| 6/19/2022 | | COM | Biggio | General | 24 |
| 6/19/2022 | | DUT | Stassi | General | 1 |
| 6/20/2022 | | SLG | Renfroe | General | 13 |
| 6/23/2022 | | DRI | Arroyo | Hit by pitch | 31 |
| 6/23/2022 | | SYN | Torrens | General | 4 |
| 6/25/2022 | | FOR | Goldschmidt | General | 1 |
| 6/26/2022 | | FOR | Wilson,B | General | 1 |
| 6/26/2022 | | DUT | Stratton | General | 2 |
| 6/27/2022 | | DRI | Joe | General | 8 |
| 6/28/2022 | | DRI | Mercedes | General | 9 |
| 6/28/2022 | | CLE | Pham | General | 6 |
| 6/30/2022 | | DEM | Howard,Sp | General | 1 |
| 7/2/2022 | | SYN | Gallo | General | 1 |
| 7/3/2022 | | DEM | Burnes | General | 11 |
| 7/3/2022 | | RLF | Daza | General | 5 |
| 7/4/2022 | | STO | Culberson | General | 27 |
| 7/6/2022 | | SMS | Gurriel,L | General | 1 |
| 7/6/2022 | | DRI | Garcia,D | General | 11 |
| 7/7/2022 | | FOR | Rogers,Tr | General | 1 |
| 7/8/2022 | | SLG | Carlson | General | 1 |
| 7/8/2022 | | STO | Barrera,T | General | 1 |
| 7/10/2022 | | DRI | Robert | Hit by pitch | 25 |
| 7/10/2022 | | RLF | Barnhart | Hit by pitch | 19 |
| 7/12/2022 | | SMS | Alonso | General | 10 |
| 7/13/2022 | | BRO | Castro,J | Collision in field | 1 |
| 7/14/2022 | | SLG | Bader | Hit by pitch | 1 |
| 7/14/2022 | | FOR | Sale | General | 26 |
| 7/15/2022 | | COM | Mayfield | General | 1 |
| 7/17/2022 | | SLG | Avila,A | Hit by pitch | 31 |
| 7/17/2022 | | COM | Arozarena | General | 1 |
| 7/18/2022 | | SLG | Bader | General | 9 |
| 7/20/2022 | | SLG | Anderson,Bre | General | 41 |
| 7/20/2022 | | DRI | Minaya | General | 13 |
| 7/20/2022 | | BRO | Rizzo | Hit by pitch | 22 |
| 7/20/2022 | | RLF | Winker | General | 9 |
| 7/21/2022 | | DEM | Aquino | General | 21 |
| 7/21/2022 | | FOR | Garrett,B | Brawl | 13 |
| 7/21/2022 | | FOR | Mateo | Hit by pitch | 30 |
| 7/21/2022 | | FOR | Parker | Brawl | 32 |
| 7/23/2022 | | CLE | Foltynewicz | General | 6 |
| 7/24/2022 | | BRO | Soler | General | 8 |
| 7/24/2022 | | COM | Tapia,R | General | 1 |
| 7/24/2022 | | FOR | Sawamura | General | 1 |
| 7/24/2022 | | SLG | India | General | 4 |
| 7/26/2022 | | SMS | Rodon | General | 16 |
| 7/26/2022 | | SYN | Torrens | General | 3 |
| 7/27/2022 | | STO | Wade,L | General | 1 |
| 7/28/2022 | | COM | Melancon | General | 1 |
| 7/28/2022 | | SLG | Anderson,Bre | General | 1 |
| 7/29/2022 | | BRO | Andrus | General | 6 |
| 7/29/2022 | | CLE | Mancini | General | 6 |
| 7/30/2022 | | SMS | Garcia,Av | General | 4 |
| 7/31/2022 | | DRI | Familia | General | 19 |
| 7/31/2022 | | SMS | Rodon | General | 26 |
| 7/31/2022 | | DUT | Darvish | General | 6 |
| 8/1/2022 | | FOR | Hernandez,Ce | General | 1 |
| 8/1/2022 | | SLG | Kaprielian | General | 31 |
| 8/4/2022 | | STO | Grossman | General | 3 |
| 8/4/2022 | | SYN | Torrens | General | 4 |
| 8/5/2022 | | DRI | Diaz,I | General | 1 |
| 8/6/2022 | | DRI | Brothers | General | 5 |
| 8/6/2022 | | DRI | Mercedes | Hit by pitch | 3 |
| 8/7/2022 | | DRI | Manoah | General | 16 |
| 8/7/2022 | | RLF | Duvall | General | 3 |
| 8/7/2022 | | SYN | Hampson | General | 1 |
| 8/8/2022 | | BRO | Velasquez | General | 21 |
| 8/8/2022 | | RLF | Barnhart | Hit by pitch | 19 |
| 8/10/2022 | | SYN | Tucker,K | General | 1 |
| 8/10/2022 | | DRI | Gonzalez,M | General | 1 |
| 8/11/2022 | | SYN | Kepler | Hit by pitch | 5 |
| 8/11/2022 | | CLE | Pham | General | 3 |
| 8/13/2022 | | BRO | Moore,D | General | 9 |
| 8/13/2022 | | BRO | Velasquez | General | 16 |
| 8/14/2022 | | BRO | Lowe,B | Hit by pitch | 9 |
| 8/15/2022 | | SLG | Chang | General | 2 |
| 8/16/2022 | | DRI | Arrieta | General | 26 |
| 8/16/2022 | | DRI | Goudeau | General | 10 |
| 8/16/2022 | | SLG | Duffy,M | General | 2 |
| 8/17/2022 | | DUT | Espino | General | 1 |
| 8/17/2022 | | CLE | Sheets | General | 4 |
| 8/18/2022 | | BRO | Soto,J | Hit by pitch | 12 |
| 8/18/2022 | | RLF | Freeman,F | General | 1 |
| 8/19/2022 | | SMS | Narvaez | General | 6 |
| 8/19/2022 | | DUT | Happ,JA | General | 1 |
| 8/20/2022 | | STO | Alvarez,J | General | 15 |
| 8/20/2022 | | STO | Musgrove | Hit by pitch | 6 |
| 8/21/2022 | | BRO | Nunez,Do | General | 3 |
| 8/21/2022 | | SLG | Castro,K | General | 7 |
| 8/23/2022 | | DEM | Rojas,JL | General | 13 |
| 8/23/2022 | | STO | Alfaro | Hit by pitch | 14 |
| 8/24/2022 | | SMS | Ozuna | General | 14 |
| 8/24/2022 | | COM | Crowe | General | 11 |
| 8/25/2022 | | BRO | Vogelbach | General | 1 |
| 8/25/2022 | | COM | Hicks,A | Hit by pitch | 13 |
| 8/26/2022 | | FOR | Lauer | General | 6 |
| 8/27/2022 | | DEM | Anderson,Bri | General | 16 |
| 8/27/2022 | | COM | Widener | General | 1 |
| 8/28/2022 | | SLG | Rodgers | General | 14 |
| 8/29/2022 | | BRO | Urena | General | 1 |
| 8/29/2022 | | SLG | Taveras | Hit by pitch | 11 |
| 8/31/2022 | | RLF | Hill,R | General | 16 |
| 9/2/2022 | | DUT | Reyes,A | General | 1 |
| 9/3/2022 | | DEM | Rojas,JL | General | 18 |
| 9/3/2022 | | SLG | Cobb | General | 11 |
| 9/3/2022 | | RLF | Kim,K | General | 2 |
| 9/3/2022 | | RLF | Suarez,J | General | 6 |
| 9/4/2022 | | DUT | Brosseau | General | 6 |
| 9/4/2022 | | STO | Realmuto | General | 1 |
| 9/4/2022 | | SLG | Kaprielian | General | 1 |
| 9/4/2022 | | RLF | Sanchez,J | General | 8 |
| 9/5/2022 | | SLG | Keller,M | General | 1 |
| 9/5/2022 | | FOR | Hernandez,Ce | General | 1 |
| 9/9/2022 | | BRO | Rizzo | Hit by pitch | 2 |
| 9/9/2022 | | CLE | DeJong | Hit by pitch | 18 |
| 9/12/2022 | | STO | Barrera,T | General | 5 |
| 9/12/2022 | | CLE | Finnegan | General | 1 |
| 9/12/2022 | | SLG | Zimmerman | General | 1 |
| 9/13/2022 | | BRO | Soler | General | 6 |
| 9/13/2022 | | CLE | Miller,O | General | 4 |
| 9/13/2022 | | COM | Franco,M | Hit by pitch | 2 |
| 9/14/2022 | | RLF | Alexander,T | General | 11 |
| 9/16/2022 | | SLG | Reed,J | General | 26 |
| 9/16/2022 | | CLE | Yelich | General | 2 |
| 9/16/2022 | | FOR | Rojas,J | General | 1 |
| 9/17/2022 | | SMS | Mountcastle | General | 2 |
| 9/17/2022 | | COM | Franco,M | General | 18 |
| 9/18/2022 | | DRI | Diaz,I | General | 4 |
| 9/18/2022 | | DRI | Gonzalez,M | Hit by pitch | 23 |
| 9/18/2022 | | STO | Lynn | General | 1 |
| 9/18/2022 | | SLG | Escobar,A | General | 3 |
| 9/19/2022 | | STO | Zunino | Hit by pitch | 1 |
| 9/20/2022 | | COM | Stanton | General | 8 |
| 9/21/2022 | | STO | Ottavino | General | 3 |
| 10/3/2022 | | SMS | Houser | General | 21 |
| 10/3/2022 | | RLF | Freeman,F | General | 1 |
| 10/14/2022 | | RLF | Wong,Ko | General | 7 |
| 10/28/2022 | | SYN | France | Hit by pitch | 1 |